Overview of Renal Replacement Therapy Use in a General Intensive Care Unit

Population-based studies regarding renal replacement therapy (RRT) used in critical care populations are useful to understand the trend and impact of medical care interventions. We describe the use of RRT and associated outcomes (mortality and length of intensive care stay) in a level 1 hospital. A...

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Bibliographic Details
Published in:	International journal of environmental research and public health Vol. 19; no. 4; p. 2453
Main Authors:	Tiglis, Mirela, Peride, Ileana, Florea, Iulia Alexandra, Niculae, Andrei, Petcu, Lucian Cristian, Neagu, Tiberiu Paul, Checherita, Ionel Alexandru, Grintescu, Ioana Marina
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 21-02-2022 MDPI
Subjects:	Acute Kidney Injury - therapy Age Aged Aged, 80 and over APACHE Female Gender Hospitals Humans Hypotheses Independent sample Intensive care Intensive Care Units Kidney diseases Male Medical records Middle Aged Mortality Multiple organ dysfunction syndrome Patients Population studies Population-based studies Renal Replacement Therapy Retrospective Studies Software Statistical analysis Survival analysis Transfusion Trauma Trends Variables Ventilators critical care mortality renal replacement therapy ICU scores length of ICU stay
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Summary:	Population-based studies regarding renal replacement therapy (RRT) used in critical care populations are useful to understand the trend and impact of medical care interventions. We describe the use of RRT and associated outcomes (mortality and length of intensive care stay) in a level 1 hospital. A retrospective descriptive observational study. Critically ill patients admitted to the ICU from 1 January to 31 December 2018. Age, gender, ward of admission, primary organ dysfunction at admission, length of hospital stay (LOS), mechanical ventilation, APACHE, SOFA and ISS scores, the use of vasopressors, transfusion, RRT and the number of RRT sessions were extracted. 1703 critically ill patients were divided into two groups: the RRT-group (238 patients) and the non-RRT group (1465 patients). The mean age was 63.58 ± 17.52 (SD) in the final ICU studied patients (64.72 ± 16.64 SD in the RRT-group), 60.5% being male. Patients admitted from general surgery ward needing RRT were 41.4%. The specific scores, the use of vasopressors, transfusions and mortality were higher in the RRT-group. The ICU LOS was superior in the RRT-group, regardless of the primary organ dysfunction. RRT was practiced in 13.9% of patients (especially after age of 61), with mortality being the outcome for 66.8% of the RRT-group patients. All analyzed data were higher in the RRT group, especially for multiple trauma and surgical patients, or patients presenting cardiac or renal dysfunctions at admission. We found significant increased ISS scores in the RRT-group, a significant association between the need of vasopressors or transfusion requirement and RRT use, and an association in the number of RRT sessions and LOS ( < 0.001).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1660-4601 1661-7827 1660-4601
DOI:	10.3390/ijerph19042453