Search Results - "Florea, I."

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 by van Esbroeck, Annelot C. M., Janssen, Antonius P. A., Cognetta, Armand B., Ogasawara, Daisuke, Shpak, Guy, van der Kroeg, Mark, Kantae, Vasudev, Baggelaar, Marc P., de Vrij, Femke M. S., Deng, Hui, Allarà, Marco, Fezza, Filomena, Lin, Zhanmin, van der Wel, Tom, Soethoudt, Marjolein, Mock, Elliot D., den Dulk, Hans, Baak, Ilse L., Florea, Bogdan I., Hendriks, Giel, De Petrocellis, Luciano, Overkleeft, Herman S., Hankemeier, Thomas, De Zeeuw, Chris I., Di Marzo, Vincenzo, Maccarrone, Mauro, Cravatt, Benjamin F., Kushner, Steven A., van der Stelt, Mario

“…A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to the death of one volunteer and produced mild-to-severe…”
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Exploring nanomaterials with 3D electron microscopy by Ersen, O., Florea, I., Hirlimann, C., Pham-Huu, C.

“…In this review we focus on recent developments in the field of 3D imaging at the nanoscale, when applied to nanomaterials and nanostructures. We demonstrate,…”
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NbN thin films grown on silicon by molecular beam epitaxy for superconducting detectors by Iovan, A., Pedeches, A., Descamps, T., Rotella, H., Florea, I., Semond, F., Zwiller, V.

“…Superconducting nanowire single photon detectors (SNSPDs) made with thin NbN films can reach high performances. While sputtering has been the deposition method…”
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Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division by Chang, John T., Ciocca, Maria L., Kinjyo, Ichiko, Palanivel, Vikram R., McClurkin, Courtney E., DeJong, Caitlin S., Mooney, Erin C., Kim, Jiyeon S., Steinel, Natalie C., Oliaro, Jane, Yin, Catherine C., Florea, Bogdan I., Overkleeft, Herman S., Berg, Leslie J., Russell, Sarah M., Koretzky, Gary A., Jordan, Martha S., Reiner, Steven L.

“…Polarized segregation of proteins in T cells is thought to play a role in diverse cellular functions including signal transduction, migration, and directed…”
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New method for the growth of single-walled carbon nanotubes from bimetallic nanoalloy catalysts based on Prussian blue analog precursors by Castan, A., Forel, S., Catala, L., Florea, I., Fossard, F., Bouanis, F., Andrieux-Ledier, A., Mazerat, S., Mallah, T., Huc, V., Loiseau, A., Cojocaru, C.S.

“…Catalyst engineering is a key point for selective growth of single-walled carbon nanotubes (SWCNT) with chemical vapor deposition (CVD). Here, we develop a new…”
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Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis by Reichelt, Julia, Sachs, Wiebke, Frömbling, Sarah, Fehlert, Julia, Studencka-Turski, Maja, Betz, Anna, Loreth, Desiree, Blume, Lukas, Witt, Susanne, Pohl, Sandra, Brand, Johannes, Czesla, Maire, Knop, Jan, Florea, Bogdan I., Zielinski, Stephanie, Sachs, Marlies, Hoxha, Elion, Hermans-Borgmeyer, Irm, Zahner, Gunther, Wiech, Thorsten, Krüger, Elke, Meyer-Schwesinger, Catherine

“…Little is known about the mechanistic significance of the ubiquitin proteasome system (UPS) in a kidney autoimmune environment. In membranous nephropathy (MN),…”
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Activity-based protein profiling: an enabling technology in chemical biology research by Li, Nan, Overkleeft, Herman S, Florea, Bogdan I

“…► Activity based probes covalently bind to enzymes, labeling their activity with a reporter tag. ► Activity-based protein profiling helps in unraveling…”
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Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities by Willems, Lianne I., Li, Nan, Florea, Bogdan I., Ruben, Mark, van der Marel, Gijsbert A., Overkleeft, Herman S.

“…Three at the same time: A ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)‐catalyzed click reaction…”
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The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration by Sachs, Wiebke, Blume, Lukas, Loreth, Desiree, Schebsdat, Lisa, Hatje, Favian, Koehler, Sybille, Wedekind, Uta, Sachs, Marlies, Zieliniski, Stephanie, Brand, Johannes, Conze, Christian, Florea, Bogdan I., Heppner, Frank, Krüger, Elke, Rinschen, Markus M., Kretz, Oliver, Thünauer, Roland, Meyer-Schwesinger, Catherine

“…Kidney filtration is ensured by the interaction of podocytes, endothelial and mesangial cells. Immunoglobulin accumulation at the filtration barrier is…”
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Metal-Dependent Interplay between Crystallization and Phosphorus Diffusion during the Synthesis of Metal Phosphide Nanoparticles by Carenco, S, Hu, Y, Florea, I, Ersen, O, Boissière, C, Mézailles, N, Sanchez, C

“…The interplay between crystallization and phosphorus diffusion in the versatile synthesis of metal phosphide nanoparticles from well-defined metal…”
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Unbiased Identification of the Liposome Protein Corona using Photoaffinity-based Chemoproteomics by Pattipeiluhu, Roy, Crielaard, Stefan, Klein-Schiphorst, Iris, Florea, Bogdan I, Kros, Alexander, Campbell, Frederick

“…Protein adsorption to the surface of a nanoparticle can fundamentally alter the character, behavior, and fate of a nanoparticle in vivo. Current methods to…”
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Publisher Correction: Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis by Reichelt, Julia, Sachs, Wiebke, Frömbling, Sarah, Fehlert, Julia, Studencka-Turski, Maja, Betz, Anna, Loreth, Desiree, Blume, Lukas, Witt, Susanne, Pohl, Sandra, Brand, Johannes, Czesla, Maire, Knop, Jan, Florea, Bogdan I., Zielinski, Stephanie, Sachs, Marlies, Hoxha, Elion, Hermans-Borgmeyer, Irm, Zahner, Gunther, Wiech, Thorsten, Krüger, Elke, Meyer-Schwesinger, Catherine

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PABPN1-Dependent mRNA Processing Induces Muscle Wasting by Riaz, Muhammad, Raz, Yotam, van Putten, Maaike, Paniagua-Soriano, Guillem, Krom, Yvonne D, Florea, Bogdan I, Raz, Vered

“…Poly(A) Binding Protein Nuclear 1 (PABPN1) is a multifunctional regulator of mRNA processing, and its expression levels specifically decline in aging muscles…”
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A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence by Jiang, Ming, Huizenga, Mirjam C. W., Wirt, Jonah L., Paloczi, Janos, Amedi, Avand, van den Berg, Richard J. B. H. N., Benz, Joerg, Collin, Ludovic, Deng, Hui, Di, Xinyu, Driever, Wouter F., Florea, Bogdan I., Grether, Uwe, Janssen, Antonius P. A., Hankemeier, Thomas, Heitman, Laura H., Lam, Tsang-Wai, Mohr, Florian, Pavlovic, Anto, Ruf, Iris, van den Hurk, Helma, Stevens, Anna F., van der Vliet, Daan, van der Wel, Tom, Wittwer, Matthias B., van Boeckel, Constant A. A., Pacher, Pal, Hohmann, Andrea G., van der Stelt, Mario

“…Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic…”
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C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties by Inagawa, Takabumi, Wennink, Thomas, Lebbink, Joyce H G, Keijzers, Guido, Florea, Bogdan I, Verkaik, Nicole S, van Gent, Dik C

“…The Ku70/80 heterodimer binds to DNA ends and attracts other proteins involved in the non-homologous end-joining (NHEJ) pathway of DNA double-strand break…”
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Nonlinear Integral Formulation and Neural Network-Based Solution for Reconstruction of Deep Defects With Pulse Eddy Currents by Preda, Gabriel, Hantila, Florea I.

“…A method for reconstruction of defects buried deep under material surface of conductive nonlinear materials is proposed. Defects are approximated as zero…”
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Dynamic Assembly of End-Joining Complexes Requires Interaction between Ku70/80 and XRCC4 by Mari, Pierre-Olivier, Florea, Bogdan I., Persengiev, Stephan P., Verkaik, Nicole S., Brüggenwirth, Hennie T., Modesti, Mauro, Giglia-Mari, Giuseppina, Bezstarosti, Karel, Demmers, Jeroen A. A., Luider, Theo M., Houtsmuller, Adriaan B., van Gent, Dik C.

“…DNA double-strand break (DSB) repair by nonhomologous end joining (NHEJ) requires the assembly of several proteins on DNA ends. Although biochemical studies…”
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Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis by van der Wel, Tom, Hilhorst, Riet, den Dulk, Hans, van den Hooven, Tim, Prins, Nienke M., Wijnakker, Joost A. P. M., Florea, Bogdan I., Lenselink, Eelke B., van Westen, Gerard J. P., Ruijtenbeek, Rob, Overkleeft, Herman S., Kaptein, Allard, Barf, Tjeerd, van der Stelt, Mario

“…Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug…”
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Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling by Willems, Lianne I, van der Linden, Wouter A, Li, Nan, Li, Kah-Yee, Liu, Nora, Hoogendoorn, Sascha, van der Marel, Gijs A, Florea, Bogdan I, Overkleeft, Herman S

“…The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After…”
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Stage-Dependent Axon Transport of Proteasomes Contributes to Axon Development by Hsu, Meng-Tsung, Guo, Chin-Lin, Liou, Angela Y., Chang, Ting-Ya, Ng, Ming-Chong, Florea, Bogdan I., Overkleeft, Herman S., Wu, Yen-Lin, Liao, Jung-Chi, Cheng, Pei-Lin

“…Axon extension at the growing tip requires elevated local protein supply, with a capability sustainable over long axons in varying environments. The exact…”
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