Search Results - "Flor, Peter Josef"

The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors by Pagano, Adriana, Rüegg, Doris, Litschig, Stephane, Stoehr, Natacha, Stierlin, Christine, Heinrich, Micheline, Floersheim, Philipp, Prezèau, Laurent, Carroll, Fiona, Pin, Jean-Philippe, Cambria, Antonio, Vranesic, Ivo, Flor, Peter Josef, Gasparini, Fabrizio, Kuhn, Rainer

“…We have investigated the mechanism of inhibition and site of action of the novel human metabotropic glutamate receptor 5 (hmGluR5) antagonist…”
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CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding by Litschig, S, Gasparini, F, Rueegg, D, Stoehr, N, Flor, P J, Vranesic, I, Prézeau, L, Pin, J P, Thomsen, C, Kuhn, R

“…Metabotropic glutamate receptors (mGluRs) are a family of G protein-coupled receptors characterized by a large, extracellular N-terminal domain comprising the…”
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Metabotropic glutamate receptor subtype 7 ablation causes deficit in social behaviors by Masugi-Tokita, Miwako, Flor, Peter Josef, van der Putten, Herman, Kawata, Mitsuhiro

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Design, synthesis and preliminary evaluation of novel 3′-Substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors by Pellicciari, Roberto, Costantino, Gabriele, Marinozzi, Maura, Macchiarulo, Antonio, Amori, Laura, Josef Flor, Peter, Gasparini, Fabrizio, Kuhn, Rainer, Urwyler, Stephan

“…Two novel 3′-substituted carboxycylopropylglycines, ( 2S, 1′S, 2′S, 3′R )-2-(3′-xanthenylmethyl-2′-carboxycyclopropyl)glycine ( 8a) and ( 2S, 1′S, 2′S, 3′R…”
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AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization by Vranesic, Ivo, Ofner, Silvio, Flor, Peter Josef, Bilbe, Graeme, Bouhelal, Rochdi, Enz, Albert, Desrayaud, Sandrine, McAllister, Kevin, Kuhn, Rainer, Gasparini, Fabrizio

“…[Display omitted] Here we describe the identification, structure–activity relationship and the initial pharmacological characterization of AFQ056/mavoglurant,…”
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Metabotropic glutamate receptor subtype 7 knockout mice show deficit in social behaviors by Masugi-Tokita, Miwako, Flor, Peter Josef, Kawata, Mitsuhiro

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[ 3H]-M-MPEP, a Potent, Subtype-Selective Radioligand for the Metabotropic Glutamate Receptor Subtype 5 by Gasparini, Fabrizio, Andres, Hendrik, Flor, Peter Josef, Heinrich, Micheline, Inderbitzin, Werner, Lingenhöhl, Kurt, Müller, Hanspeter, Munk, Veronica Cecilia, Omilusik, Kyla, Stierlin, Christine, Stoehr, Natacha, Vranesic, Ivo, Kuhn, Rainer

“…The identification of a novel potent, subtype-selective antagonist of the metabotropic glutamate receptor 5 (mGluR-5) is reported. The radiolabeling with…”
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Chiral Resolution, Pharmacological Characterization, and Receptor Docking of the Noncompetitive mGlu1 Receptor Antagonist (±)-2-Hydroxyimino- 1a,2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic Acid Ethyl Ester by Ott, David, Floersheim, Philipp, Inderbitzin, Werner, Stoehr, Natacha, Francotte, Eric, Lecis, Gabrielle, Richert, Paul, Rihs, Grety, Flor, Peter Josef, Kuhn, Rainer, Gasparini, Fabrizio

“…Racemic CPCCOEt ((1aRS,7aRS)-2-hydroxyimino-1a,2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester, (±)-1) derivatives have been shown to…”
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Chiral Resolution, Pharmacological Characterization, and Receptor Docking of the Noncompetitive mGlu1 Receptor Antagonist (±)-2-Hydroxyimino- 1a,2-dihydro-1 H -7-oxacyclopropa[ b ]naphthalene-7a-carboxylic Acid Ethyl Ester by Ott, David, Floersheim, Philipp, Inderbitzin, Werner, Stoehr, Natacha, Francotte, Eric, Lecis, Gabrielle, Richert, Paul, Rihs, Grety, Flor, Peter Josef, Kuhn, Rainer, Gasparini, Fabrizio

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Discovery and characterization of non-competitive antagonists of group I metabotropic glutamate receptors by Gasparini, Fabrizio, Floersheim, Philipp, Flor, Peter Josef, Heinrich, Micheline, Inderbitzin, Werner, Ott, David, Pagano, Adriana, Stierlin, Christine, Stoehr, Natacha, Vranesic, Ivo, Kuhn, Rainer

“…We have investigated the mechanism of inhibition of the new group I mGluR antagonists CPCCOEt and MPEP and determined that both compounds have a…”
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