Search Results - "Flood, D G"

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease by West, M J, Coleman, P D, Flood, D G, Troncoso, J C

“…The distinction between the neurodegenerative changes that accompany normal ageing and those that characterise Alzheimer's disease is not clear. The resolution…”
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Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy by SHEFNER, J. M, REAUME, A. G, FLOOD, D. G, SCOTT, R. W, KOWALL, N. W, FERRANTE, R. J, SIWEK, D. F, UPTON-RICE, M, BROWN, R. H

“…To characterize the motor neuron dysfunction in two models by performing physiologic and morphometric studies. Mutations in the gene encoding cytosolic…”
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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury by Reaume, Andrew. G, Elliott, Jeffrey L, Hoffman, Eric K, Kowall, Neil W, Ferrante, Robert J, Siwek, Donald R, Wilcox, Heide M, Flood, Dorothy G, Beal, M. Flint, Brown, Robert H, Scott, Richard W, Snider, William D

“…The discovery that some cases of familial amyotrophic lateral sclerosis (FALS) are associated with mutations in the gene encoding Cu/Zn superoxide dismutase…”
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Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase by McFadden, Sandra L, Ding, Dalian, Reaume, Andrew G, Flood, Dorothy G, Salvi, Richard J

“…Age-related hearing loss in humans and many strains of mice is associated with a base-to-apex gradient of cochlear hair cell loss. To determine if copper/zinc…”
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Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss by Ohlemiller, K K, McFadden, S L, Ding, D L, Flood, D G, Reaume, A G, Hoffman, E K, Scott, R W, Wright, J S, Putcha, G V, Salvi, R J

“…Reactive oxygen species (ROS) such as superoxide, peroxide and hydroxyl radicals are generated during normal cellular metabolism and are increased in acute…”
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Hindlimb Motor Neurons Require Cu/Zn Superoxide Dismutase for Maintenance of Neuromuscular Junctions by Flood, Dorothy G., Reaume, Andrew G., Gruner, John A., Hoffman, Eric K., Hirsch, James D., Lin, Yin-Guo, Dorfman, Karen S., Scott, Richard W.

“…The role of oxidative damage in neurodegenerative disease was investigated in mice lacking cytoplasmic Cu/Zn superoxide dismutase (SOD), created by deletion of…”
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Activation of c-Jun N-Terminal Kinase and p38 in an Alzheimer's Disease Model Is Associated with Amyloid Deposition by Savage, Mary J, Lin, Yin-Guo, Ciallella, John R, Flood, Dorothy G, Scott, Richard W

“…The mechanisms by which neurons and synapses are lost in Alzheimer's disease (AD) are not completely understood. To characterize potential signaling events…”
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Increased levels of hemoglobin-derived and other peptides in Alzheimer's disease cerebellum by Slemmon, JR, Hughes, CM, Campbell, GA, Flood, DG

“…Several studies point to the importance of peptides and proteolysis in Alzheimer's disease (AD). Because of its ability to study small proteins and peptides,…”
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Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation by Siman, R, Flood, D G, Thinakaran, G, Neumar, R W

“…Endoplasmic reticulum (ER) stress elicits protective responses of chaperone induction and translational suppression and, when unimpeded, leads to…”
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Dendritic regression dissociated from neuronal death but associated with partial deafferentation in aging rat supraoptic nucleus by Flood, D G, Coleman, P D

“…As neurons are lost in normal aging, the dendrites of surviving neighbor neurons may proliferate, regress, or remain unchanged. In the case of age-related…”
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Synaptic loss in the central nucleus of the inferior colliculus correlates with sensorineural hearing loss in the C57BL/6 mouse model of presbycusis by Kazee, Ann M., Han, Li Ying, Spongr, Vlasta P., Walton, Joseph P., Salvi, Richard J., Flood, Dorothy G.

“…Between 3 and 25 months of age, light and electron microscopic features of principal neurons in the central nucleus of the inferior colliculus of the C57BL/6…”
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Profiling of endogenous peptides as a tool for studying development and neurological disease by Slemmon, J. Randall, Wengenack, Thomas M., Flood, Dorothy G.

“…The use of a method to follow changes in endogenous peptide production, as they occur in biological studies, is an excellent complement to other molecular…”
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Presenilin-1 P264L Knock-In Mutation: Differential Effects on Aβ Production, Amyloid Deposition, and Neuronal Vulnerability by Siman, Robert, Reaume, Andrew G., Savage, Mary J., Trusko, Stephen, Lin, Yin-Guo, Scott, Richard W., Flood, Dorothy G.

“…The pathogenic mechanism linking presenilin-1 (PS-1) gene mutations to familial Alzheimer's disease (FAD) is uncertain, but has been proposed to include…”
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Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol by Howland, D S, Trusko, S P, Savage, M J, Reaume, A G, Lang, D M, Hirsch, J D, Maeda, N, Siman, R, Greenberg, B D, Scott, R W, Flood, D G

“…The effects of dietary cholesterol on brain amyloid precursor protein (APP) processing were examined using an APP gene-targeted mouse, genetically humanized in…”
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FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction by Flood, Dorothy G, Reaume, Andrew G, Dorfman, Karen S, Lin, Yin Guo, Lang, Diane M, Trusko, Stephen P, Savage, Mary J, Annaert, Wim G, De Strooper, Bart, Siman, Robert, Scott, Richard W

“…To investigate the consequences of mutant presenilin-1 (PS-1) expression under the control of the normal PS-1 gene, a gene-targeted mouse bearing the FAD…”
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Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia by Flood, D G, Buell, S J, Horwitz, G J, Coleman, P D

“…Granule cells of the hippocampal dentate gyrus of 22 human brains obtained at autopsy were studied in Golgi-Cox stained tissue. Seventeen cases were…”
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Quantitative measures of hair cell loss in CBA and C57BL/6 mice throughout their life spans by Spongr, V P, Flood, D G, Frisina, R D, Salvi, R J

“…The CBA mouse shows little evidence of hearing loss until late in life, whereas the C57BL/6 strain develops a severe and progressive, high-frequency…”
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Dendritic proliferation in the aging brain as a compensatory repair mechanism by Coleman, P D, Flood, D G

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Profiling of endogenous brain peptides and small proteins: methodology, computer-assisted analysis, and application to aging and lesion models by Slemmon, J R, Flood, D G

“…Significant advances in the technology for the isolation of peptides and small proteins have permitted their identification as biologic markers and enhanced…”
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Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD‐1 mice by McFadden, Sandra L., Ding, Dalian, Burkard, Robert F., Jiang, Haiyan, Reaume, Andrew G., Flood, Dorothy G., Salvi, Richard J.

“…Copper/zinc superoxide dismutase (Cu/Zn SOD) is a first‐line defense against free radical damage in the cochlea and other tissues. To determine whether…”
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