Changes in C-reactive protein during weight loss and the association with changes in anthropometric variables in men and women: LIFE Study

Changes in C-reactive protein during weight loss and the association with changes in anthropometric variables in men and women: LIFE Study

Objective: To investigate whether sex differences exist in the pattern of change in C-reactive protein (CRP) levels during weight loss, and whether the associations between weight change and CRP change differ by the types of anthropometric variables. Design: Longitudinal, prospective analysis of sub...

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Bibliographic Details
Published in:International Journal of Obesity Vol. 35; no. 5; pp. 684 - 691
Main Authors: Yatsuya, H, Jeffery, R.W, Langer, S.L, Mitchell, N, Flood, A.P, Welsh, E.M, Jaeb, M.A, Laqua, P.S, Crowell, M, Levy, R.L
Format: Journal Article
Language:English
Published: London Nature Publishing Group 01-05-2011
Nature Publishing Group UK
Subjects:
631/45/612/1221
692/308/2779/174
692/699/1702/393
Adult
Age
Aged
Anthropometry
Body mass
Body Mass Index
C-reactive protein
C-Reactive Protein - metabolism
Diabetes
Epidemiology
Expenditures
Female
Females
Gender differences
Health Promotion and Disease Prevention
Hips
Humans
Inflammation Mediators - metabolism
Interleukin-6 - metabolism
Internal Medicine
lifestyle
Longitudinal Studies
Male
males
Medicine
Medicine & Public Health
Men
Metabolic Diseases
Middle Aged
Obesity
Obesity - metabolism
Obesity - physiopathology
original-article
Physiological aspects
Prospective Studies
Proteins
Public Health
Sex differences
Sex Factors
waist
waist-to-hip ratio
Weight
Weight control
Weight loss
Weight Loss - physiology
Women
Young Adult
United States
United States > US
sex characteristics
anthropometric variables
longitudinal study
C-reactive protein
weight change
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Summary:Objective: To investigate whether sex differences exist in the pattern of change in C-reactive protein (CRP) levels during weight loss, and whether the associations between weight change and CRP change differ by the types of anthropometric variables. Design: Longitudinal, prospective analysis of subjects participating in an intentional weight loss trial (the Lose It For Ever: LIFE Study) followed-up for 30 months. Subjects: A total of 212 healthy, obese men and women (age: 23-77 years, body mass index (BMI): 30-39 kg m-2) took part in this study. Measurements: BMI, waist and hip circumferences, and waist-to-hip ratio, CRP and lifestyle variables repeatedly measured at baseline, 6, 12, 18 and 30-month follow-up. Results: Weight change was J shaped with a nadir at 12 months in both men and women (P for month2 <0.0001). CRP level was consistently higher in women than in men, but the differences were less prominent and were not statistically significant at 12- and 18-month follow-up. CRP changes between any two consecutive visits were significantly associated with changes in BMI during the same period in women. However, the associations between CRP changes and changes in waist or hip circumference were not as consistent, especially between 18- and 30-month follow-up when CRP significantly increased. The associations in men were generally similar among the different anthropometric measures. The association between changes in BMI and CRP was stronger in men than in women. Conclusion: BMI change generally correlated well with CRP changes in both men and women in the course of follow-up. Significant sex difference in CRP level at baseline diminished at 12- and 18-month follow-up, when both sexes had maintained the lost weight.
Bibliography:http://dx.doi.org/10.1038/ijo.2010.200
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ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2010.200