Search Results - "Flodgaard, H"

Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin by Lindmark, Anders, Garwicz, Daniel, Rasmussen, Poul B., Flodgaard, Hans, Gullberg, Urban

“…Azurocidin is a multifunctional endotoxin‐ binding serine protease homolog synthesized during the promyelocytic stage of neutrophil development. To…”
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Diabetic late complications: Will aldose reductase inhibitors or inhibitors of advanced glycosylation endproduct formation hold promise? by Boel, Esper, Selmer, Johan, Flodgaard, Hans J., Jensen, Tonny

“…Patients suffering from the severe complications associated with both insulin- (IDDM) and noninsulin-dependent diabetes mellitus (NIDDM): nephropathy,…”
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Abundant amounts of diadenosine 5',5"'-P1,P4-tetraphosphate are present and releasable, but metabolically inactive, in human platelets by Flodgaard, H, Klenow, H

“…Diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) may be formed in the back reaction of the amino acid-activation reaction [Zamecnik, Stephenson, Janeway &…”
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Structure and function of the N-linked glycans of HBP/CAP37/azurocidin: Crystal structure determination and biological characterization of nonglycosylated HBP by IVERSEN, L.F., KASTRUP, J.S., BJØRN, S.E., WIBERG, F.C., LARSEN, I.K., FLODGAARD, H.J., RASMUSSEN, P.B.

“…The three N-glycosylation sites of human heparin binding protein (HBP) have been mutated to produce a nonglycosylated HBP (ng-HBP) mutant. ng-HBP has been…”
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A neutrophil-derived proteolytic inactive elastase homologue (hHBP) mediates reversible contraction of fibroblasts and endothelial cell monolayers and stimulates monocyte survival and thrombospondin secretion by Ostergaard, E, Flodgaard, H

“…Human heparin-binding protein (hHBP) is a recently discovered proteolytically inactive neutrophil elastase homologue with sequence identity to azurocidin and…”
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Measurement of Apoptosis by the TUNEL Method Using Scintillating Microplates by Linde, Viggo, Flodgaard, Hans, Kastrup, Jette Sandholm, Bjørn, Søren

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X-ray Structure of the 154-Amino-Acid Form of Recombinant Human Basic Fibroblast Growth Factor. Comparison with the Truncated 146-Amino-Acid Form by Kastrup, J. S., Eriksson, E. S., Dalbøge, H., Flodgaard, H.

“…The crystal structure of the 154‐amino‐acid form of human basic fibroblast growth factor (hbFGF154), probably representing the intact form of hbFGF as deduced…”
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Heparin-Binding Protein Decreases Apoptosis in Human and Murine Neutrophils by Shrotri, Milind S., Kuhn, John F., Peyton, James C., Flodgaard, Hans J., Klein, Jon B., Cheadle, William G.

“…Background. Heparin-binding protein (HBP), a serine protease without any known proteolytic activity, is found in human polymorphonuclear leukocyte (PMN)…”
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M Protein, a Classical Bacterial Virulence Determinant, Forms Complexes with Fibrinogen that Induce Vascular Leakage by Herwald, Heiko, Cramer, Henning, Mörgelin, Matthias, Russell, Wayne, Sollenberg, Ulla, Norrby-Teglund, Anna, Flodgaard, Hans, Lindbom, Lennart, Björck, Lars

“…Increased vascular permeability is a key feature of inflammatory conditions. In severe infections, leakage of plasma from the vasculature induces a…”
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Structure of HBP, a multifunctional protein with a serine proteinase fold by Iversen, Lars Fogh, Kastrup, Jette Sandholm, Bjørn, Søren Erik, Rasmussen, Poul Baad, Wiberg, Finn Christoph, Flodgaard, Hans Jacob, Larsen, Ingrid Kjøller

“…The structure of human heparin binding protein reveals that the serine proteinase fold has been used as a scaffold for a multifunctional protein with…”
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Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability by Lindbom, Lennart, Gautam, Narinder, Maria Olofsson, A, Herwald, Heiko, Iversen, Lars F, Lundgren-Åkerlund, Evy, Hedqvist, Per, Arfors, Karl-E, Flodgaard, Hans

“…Polymorphonuclear leukocyte infiltration into tissues in host defense and inflammatory disease causes increased vascular permeability and edema formation…”
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Two mutants of human heparin binding protein (CAP37): Toward the understanding of the nature of lipid A/LPS and BPTI binding by Kastrup, Jette S., Linde, Viggo, Pedersen, Anja K., Stoffer, Bjarne, Iversen, Lars F., Larsen, Ingrid K., Rasmussen, Poul B., Flodgaard, Hans J., Bjørn, Søren E.

“…Heparin binding protein (HBP) is an inactive serine protease homologue with important implications in host defense during infections and inflammations. Two…”
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Binding of low molecular weight heparin (Tinzaparin sodium) to bovine endothelial cells in vitro by Larnkjaer, A, Ostergaard, P B, Flodgaard, H J

“…Heparinase depolymerized low molecular weight (LMW) heparin (Tinzaparin sodium, Logiparin) was radiolabelled by catalytic tritiation to high specific…”
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Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles by Tapper, Hans, Karlsson, Anna, Mörgelin, Matthias, Flodgaard, Hans, Herwald, Heiko

“…Human neutrophils have an important role in host defense against microbial infection. At different stages of an infectious process, neutrophils progressively…”
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Neutrophil-Derived Heparin-Binding Protein (HBP/CAP37) Deposited on Endothelium Enhances Monocyte Arrest under Flow Conditions by Soehnlein, Oliver, Xie, Xun, Ulbrich, Holger, Kenne, Ellinor, Rotzius, Pierre, Flodgaard, Hans, Eriksson, Einar E, Lindbom, Lennart

“…In acute inflammation, infiltration of neutrophils often precedes a second phase of monocyte invasion, and data in the literature suggest that neutrophils may…”
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Comparison of the effects of methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone-inhibited neutrophil elastase with the effects of its naturally occurring mutationally inactivated homologue (HBP) on fibroblasts and monocytes in vitro by Ostergaard, E, Nielsen, O F, Flodgaard, H

“…The mature neutrophils in the circulation contain, besides the different proteases known for a long time, a recently discovered proteolytically inactive…”
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Both Hypoxanthine and Adenosine Stimulate DNA Synthesis Independently in Serum-Starved L Cells Treated with Platelet Protein by Klenow, Hans, Flodgaard, Hans

“…The effect of human platelet factors and purine derivatives on DNA synthesis has been investigated in mouse fibroblast-like L cells whose growth was arrested…”
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Platelet P1, P4-Di (adenosine-51) tetraphosphate (AP4A) in migraine patients before and during beta-adrenoceptor blockade by Winther, K, Hedman, C, Flodgaard, H

“…P1,P4-Di(adenosine-51) tetraphosphate (AP4A) is a metabolically inactive nucleotide which can be released from platelet dense granules. This study was designed…”
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Thermodynamic Parameters for the Hydrolysis of Inorganic Pyrophosphate at pH 7.4 as a Function of [Mg2+], [K+], and Ionic Strength Determined from Equilibrium Studies of the Reaction by Flodgaard, H, Fleron, P

“…The equilibrium between inorganic pyrophosphate and inorganic orthophosphate was studied by direct measurement of PP i . The reaction was catalyzed by yeast…”
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Atomic Resolution Structure of Human HBP/CAP37/Azurocidin by Karlsen, Solveig, Iversen, Lars Fogh, Larsen, Ingrid Kjøller, Flodgaard, Hans Jacob, Kastrup, Jette Sandholm

“…Crystals of human heparin binding protein (HBP) diffract to 1.1 Å when flash‐frozen at 120 K. The atomic resolution structure has been refined anisotropically…”
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