Search Results - "Floden, Angela M"

Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity by Puig, Kendra L, Floden, Angela M, Adhikari, Ramchandra, Golovko, Mikhail Y, Combs, Colin K

“…Middle age obesity is recognized as a risk factor for Alzheimer's disease (AD) although a mechanistic linkage remains unclear. Based upon the fact that obese…”
Get full text

Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice by Manocha, Gunjan D., Floden, Angela M., Miller, Nicole M., Smith, Abbie J., Nagamoto-Combs, Kumi, Saito, Takashi, Saido, Takaomi C., Combs, Colin K.

“…The amyloid beta (Aβ) peptide is associated with the neurodegenerative and inflammatory changes in brains affected by Alzheimer's disease (AD). We hypothesized…”
Get full text

IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model by Sohrabi, Mona, Floden, Angela M., Manocha, Gunjan D., Klug, Marilyn G., Combs, Colin K.

“…Aging is a major risk factor for Alzheimer’s disease (AD). Insulin like growth factor-1 receptor (IGF-1R) regulates general aging and lifespan. However, the…”
Get full text

Borrelia burgdorferi enolase is a surface-exposed plasminogen binding protein by Floden, Angela M, Watt, John A, Brissette, Catherine A

“…Borrelia burgdorferi is the causative agent of Lyme disease, the most commonly reported arthropod-borne disease in the United States. B. burgdorferi is a…”
Get full text

Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition by Rojanathammanee, Lalida, Floden, Angela M, Manocha, Gunjan D, Combs, Colin K

“…Amyloid β (Aβ) peptide is hypothesized to stimulate microglia to acquire their characteristic proinflammatory phenotype in Alzheimer's disease (AD) brains. The…”
Get full text

Salivary Aβ Secretion and Altered Oral Microbiome in Mouse Models of AD by Floden, Angela M, Sohrabi, Mona, Nookala, Suba, Cao, Jay J, Combs, Colin K

“…Beta amyloid (Aβ) peptide containing plaque aggregations in the brain are a hallmark of Alzheimer's Disease (AD). However, Aβ is produced by cell types outside…”
Get more information

BB0347, from the lyme disease spirochete Borrelia burgdorferi, is surface exposed and interacts with the CS1 heparin-binding domain of human fibronectin by Gaultney, Robert A, Gonzalez, Tammy, Floden, Angela M, Brissette, Catherine A

“…The causative agent of Lyme disease, Borrelia burgdorferi, codes for several known fibronectin-binding proteins. Fibronectin a common the target of diverse…”
Get full text

Evaluation of RevA, a Fibronectin-Binding Protein of Borrelia burgdorferi, as a Potential Vaccine Candidate for Lyme Disease by Floden, Angela M, Gonzalez, Tammy, Gaultney, Robert A, Brissette, Catherine A

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Acetate supplementation reduces microglia activation and brain interleukin-1β levels in a rat model of Lyme neuroborreliosis by Brissette, Catherine A, Houdek, Heidi M, Floden, Angela M, Rosenberger, Thad A

“…We have found that acetate supplementation significantly reduces neuroglia activation and pro-inflammatory cytokine release in a rat model of neuroinflammation…”
Get full text

Escherichia coli lipoprotein binds human plasminogen via an intramolecular domain by Gonzalez, Tammy, Gaultney, Robert A, Floden, Angela M, Brissette, Catherine A

“…Escherichia coli lipoprotein (Lpp) is a major cellular component that exists in two distinct states, bound-form and free-form. Bound-form Lpp is known to…”
Get full text

Particulate Matter Exposure Exacerbates Amyloid-β Plaque Deposition and Gliosis in APP/PS1 Mice by Sahu, Bijayani, Mackos, Amy R, Floden, Angela M, Wold, Loren E, Combs, Colin K

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and…”
Get more information

The multifaceted responses of primary human astrocytes and brain microvascular endothelial cells to the Lyme disease spirochete, Borrelia burgdorferi by Brissette, Catherine A, Kees, Eric D, Burke, Margaret M, Gaultney, Robert A, Floden, Angela M, Watt, John A

“…The vector-borne pathogen, Borrelia burgdorferi, causes a multi-system disorder including neurological complications. These neurological disorders,…”
Get full text

Amyloid-β oligomers stimulate microglia through a tyrosine kinase dependent mechanism by Dhawan, Gunjan, Floden, Angela M, Combs, Colin K

“…Abstract Alzheimer's disease (AD) has been well characterized by the presence of reactive microglia, often associated with β-amyloid (Aβ) plaque deposition…”
Get full text

House dust mite-induced asthma exacerbates Alzheimer’s disease changes in the brain of the AppNL-G-F mouse model of disease by Sahu, Bijayani, Nookala, Suba, Floden, Angela M., Ambhore, Nilesh S., Sathish, Venkatachalem, Klug, Marilyn G., Combs, Colin K.

“…•House dust mite exposure-induced asthma potentiated Aβ plaque load in AppNL-G-F mice.•Asthma increased astrogliosis and microgliosis in AppNL-G-F mice.•Asthma…”
Get full text

Anxiety-like behavior and intestinal microbiota changes as strain-and sex-dependent sequelae of mild food allergy in mouse models of cow’s milk allergy by Smith, Nicholas A., Germundson, Danielle L., Gao, Pan, Hur, Junguk, Floden, Angela M., Nagamoto-Combs, Kumi

“…•Sensitization of C57BL/6J and BALB/cJ mice to β-lactoglobulin resulted in mild hypersensitivity.•More BALB/cJ mice exhibited observable symptoms and…”
Get full text

APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease by Manocha, Gunjan D, Floden, Angela M, Rausch, Keiko, Kulas, Joshua A, McGregor, Brett A, Rojanathammanee, Lalida, Puig, Kelley R, Puig, Kendra L, Karki, Sanjib, Nichols, Michael R, Darland, Diane C, Porter, James E, Combs, Colin K

“…Prior work suggests that amyloid precursor protein (APP) can function as a proinflammatory receptor on immune cells, such as monocytes and microglia…”
Get full text

Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors by Floden, Angela M, Li, Shanshan, Combs, Colin K

“…Although abundant reactive microglia are found associated with beta-amyloid (Abeta) plaques in Alzheimer's disease (AD) brains, their contribution to cell loss…”
Get full text

Alpha-synuclein expression modulates microglial activation phenotype by Austin, Susan A, Floden, Angela M, Murphy, Eric J, Combs, Colin K

“…Recent Parkinson's disease research has focused on understanding the function of the cytosolic protein, alpha-synuclein, and its contribution to disease…”
Get full text

beta-Amyloid Stimulates Murine Postnatal and Adult Microglia Cultures in a Unique Manner by Floden, Angela M, Combs, Colin K

“…Reactive microglia are commonly observed in association with the beta-amyloid (Abeta) plaques of Alzheimer's disease brains. This localization supports the…”
Get full text

The Western progression of lyme disease: infectious and Nonclonal Borrelia burgdorferi Sensu Lato populations in Grand Forks County, North Dakota by Stone, Brandee L, Russart, Nathan M, Gaultney, Robert A, Floden, Angela M, Vaughan, Jefferson A, Brissette, Catherine A

“…Scant attention has been paid to Lyme disease, Borrelia burgdorferi, Ixodes scapularis, or reservoirs in eastern North Dakota despite the fact that it borders…”
Get full text