Search Results - "Flitsch, Sabine L"

RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades by Finnigan, William, Hepworth, Lorna J., Flitsch, Sabine L., Turner, Nicholas J.

“…As the enzyme toolbox for biocatalysis has expanded, so has the potential for the construction of powerful enzymatic cascades for efficient and selective…”
Get full text

Advancing Solutions to the Carbohydrate Sequencing Challenge by Gray, Christopher J, Migas, Lukasz G, Barran, Perdita E, Pagel, Kevin, Seeberger, Peter H, Eyers, Claire E, Boons, Geert-Jan, Pohl, Nicola L. B, Compagnon, Isabelle, Widmalm, Göran, Flitsch, Sabine L

“…Carbohydrates possess a variety of distinct features with stereochemistry playing a particularly important role in distinguishing their structure and function…”
Get full text

Whole-Cell Biocatalysts for Stereoselective C−H Amination Reactions by Both, Peter, Busch, Hanna, Kelly, Paul P., Mutti, Francesco G., Turner, Nicholas J., Flitsch, Sabine L.

“…Enantiomerically pure chiral amines are ubiquitous chemical building blocks in bioactive pharmaceutical products and their synthesis from simple starting…”
Get full text

Utility of Ion-Mobility Spectrometry for Deducing Branching of Multiply Charged Glycans and Glycopeptides in a High-Throughput Positive ion LC-FLR-IMS-MS Workflow by Pallister, Edward G, Choo, Matthew S. F, Walsh, Ian, Tai, Jien Nee, Tay, Shi Jie, Yang, Yuan Sheng, Ng, Say Kong, Rudd, Pauline M, Flitsch, Sabine L, Nguyen-Khuong, Terry

“…High-throughput glycan analysis has become an important part of biopharmaceutical production and quality control. However, it is still a significant challenge…”
Get full text

Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides by Wood, Alexander J. L., Weise, Nicholas J., Frampton, Joseph D., Dunstan, Mark S., Hollas, Michael A., Derrington, Sasha R., Lloyd, Richard C., Quaglia, Daniela, Parmeggiani, Fabio, Leys, David, Turner, Nicholas J., Flitsch, Sabine L.

“…Carboxylic acid reductases (CARs) catalyze the reduction of a broad range of carboxylic acids to aldehydes using the cofactors adenosine triphosphate and…”
Get full text

Drug Discovery and Development by Duboc, Carole, Flitsch, Sabine L

Get full text

Glycoarrays--tools for determining protein-carbohydrate interactions and glycoenzyme specificity by Laurent, Nicolas, Voglmeir, Josef, Flitsch, Sabine L

“…Carbohydrate arrays (glycoarrays) have recently emerged as a high-throughput tool for studying carbohydrate-binding proteins and carbohydrate-processing…”
Get more information

Cell-specific bioorthogonal tagging of glycoproteins by Cioce, Anna, Calle, Beatriz, Rizou, Tatiana, Lowery, Sarah C., Bridgeman, Victoria L., Mahoney, Keira E., Marchesi, Andrea, Bineva-Todd, Ganka, Flynn, Helen, Li, Zhen, Tastan, Omur Y., Roustan, Chloe, Soro-Barrio, Pablo, Rafiee, Mahmoud-Reza, Garza-Garcia, Acely, Antonopoulos, Aristotelis, Wood, Thomas M., Keenan, Tessa, Both, Peter, Huang, Kun, Parmeggian, Fabio, Snijders, Ambrosius P., Skehel, Mark, Kjær, Svend, Fascione, Martin A., Bertozzi, Carolyn R., Haslam, Stuart M., Flitsch, Sabine L., Malaker, Stacy A., Malanchi, Ilaria, Schumann, Benjamin

“…Altered glycoprotein expression is an undisputed corollary of cancer development. Understanding these alterations is paramount but hampered by limitations…”
Get full text

Bottom-Up Elucidation of Glycosidic Bond Stereochemistry by Gray, Christopher J, Schindler, Baptiste, Migas, Lukasz G, Pičmanová, Martina, Allouche, Abdul R, Green, Anthony P, Mandal, Santanu, Motawia, Mohammed S, Sánchez-Pérez, Raquel, Bjarnholt, Nanna, Møller, Birger L, Rijs, Anouk M, Barran, Perdita E, Compagnon, Isabelle, Eyers, Claire E, Flitsch, Sabine L

“…The lack of robust, high-throughput, and sensitive analytical strategies that can conclusively map the structure of glycans has significantly hampered progress…”
Get full text

Application of Biocatalysis to on‐DNA Carbohydrate Library Synthesis by Thomas, Baptiste, Lu, Xiaojie, Birmingham, William R., Huang, Kun, Both, Peter, Reyes Martinez, Juana Elizabeth, Young, Robert J., Davie, Christopher P., Flitsch, Sabine L.

“…DNA‐encoded libraries are increasingly used for the discovery of bioactive lead compounds in high‐throughput screening programs against specific biological…”
Get full text

Biocatalysis in Asia and the Pacific by Flitsch, Sabine L., Turner, Nicholas J., Li, Zhi

Get full text

Selective Inhibition of Heparan Sulphate and Not Chondroitin Sulphate Biosynthesis by a Small, Soluble Competitive Inhibitor by Maciej-Hulme, Marissa L., Dubaissi, Eamon, Shao, Chun, Zaia, Joseph, Amaya, Enrique, Flitsch, Sabine L., Merry, Catherine L. R.

“…The glycosaminoglycan, heparan sulphate (HS), orchestrates many developmental processes. Yet its biological role has not yet fully been elucidated. Small…”
Get full text

Introduction: Glycosciences by Flitsch, Sabine L.

Get full text

Chemoenzymatic Synthesis of O-Mannosylpeptides in Solution and on Solid Phase by Šardzík, Robert, Green, Anthony P, Laurent, Nicolas, Both, Peter, Fontana, Carolina, Voglmeir, Josef, Weissenborn, Martin J, Haddoub, Rose, Grassi, Paola, Haslam, Stuart M, Widmalm, Göran, Flitsch, Sabine L

“…O-Mannosyl glycans are known to play an important role in regulating the function of α-dystroglycan (α-DG), as defective glycosylation is associated with…”
Get full text

UDP-Glucose 4-Epimerase and β-1,4-Galactosyltransferase from the Oyster Magallana gigas as Valuable Biocatalysts for the Production of Galactosylated Products by Song, Hui-Bo, He, Meng, Cai, Zhi-Peng, Huang, Kun, Flitsch, Sabine L, Liu, Li, Voglmeir, Josef

“…Uridine diphosphate galactose (UDP-galactose) is a valuable building block in the enzymatic synthesis of galactose-containing glycoconjugates. UDP-glucose…”
Get full text

Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase by Ioannou, Avgousta, Cini, Elena, Timofte, Roxana S, Flitsch, Sabine L, Turner, Nicholas J, Linclau, Bruno

“…Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the…”
Get more information

Accelerated Enzymatic Galactosylation of N‑Acetylglucosaminolipids in Lipid Microdomains by Noble, Gavin T, Craven, Faye L, Voglmeir, Josef, Šardzík, Robert, Flitsch, Sabine L, Webb, Simon J

“…A fluoro-tagged N-acetylglucosamine-capped glycolipid that can form lipid microdomains in fluid phospholipid bilayers has been shown to be enzymatically…”
Get full text

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum by Cross, Benedict C.S, McKibbin, Craig, Callan, Anna C, Roboti, Peristera, Piacenti, Michela, Rabu, Catherine, Wilson, Cornelia M, Whitehead, Roger, Flitsch, Sabine L, Pool, Martin R, High, Stephen, Swanton, Eileithyia

“…Production and trafficking of proteins entering the secretory pathway of eukaryotic cells is coordinated at the endoplasmic reticulum (ER) in a process that…”
Get full text

Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry by Yan, Cunyu, Schmidberger, Jason W, Parmeggiani, Fabio, Hussain, Shaneela A, Turner, Nicholas J, Flitsch, Sabine L, Barran, Perdita

“…The combination of stable isotope labelling with direct infusion ion mobility mass spectrometry (IM-MS) enabled qualitative and quantitative monitoring of…”
Get more information

Enzymatic Synthesis of Trideuterated Sialosides by Cai, Zhi-P, Conway, Louis P, Huang, Ying Y, Wang, Wen J, Laborda, Pedro, Wang, Ting, Lu, Ai M, Yao, Hong L, Huang, Kun, Flitsch, Sabine L, Liu, Li, Voglmeir, Josef

“…Sialic acids are a family of acidic monosaccharides often found on the termini of cell surface proteins or lipid glycoconjugates of higher animals. Herein we…”
Get full text