Search Results - "Flippen, J. L"

Remediation of the protein data bank archive by Henrick, Kim, Feng, Zukang, Bluhm, Wolfgang F, Dimitropoulos, Dimitris, Doreleijers, Jurgen F, Dutta, Shuchismita, Flippen-Anderson, Judith L, Ionides, John, Kamada, Chisa, Krissinel, Eugene, Lawson, Catherine L, Markley, John L, Nakamura, Haruki, Newman, Richard, Shimizu, Yukiko, Swaminathan, Jawahar, Velankar, Sameer, Ory, Jeramia, Ulrich, Eldon L, Vranken, Wim, Westbrook, John, Yamashita, Reiko, Yang, Huanwang, Young, Jasmine, Yousufuddin, Muhammed, Berman, Helen M

“…The Worldwide Protein Data Bank (wwPDB; wwpdb.org) is the international collaboration that manages the deposition, processing and distribution of the PDB…”
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Methyl Analogues of the Experimental Alzheimer Drug Phenserine:  Synthesis and Structure/Activity Relationships for Acetyl- and Butyrylcholinesterase Inhibitory Action by Yu, Qian-sheng, Holloway, Harold W, Flippen-Anderson, Judith L, Hoffman, Brian, Brossi, Arnold, Greig, Nigel H

“…With the goal of developing potential Alzheimer's pharmacotherapeutics, we have synthesized a series of novel analogues of the potent anticholinesterases…”
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Crystal structure of [Leu1]zervamicin, a membrane ion-channel peptide: implications for gating mechanisms by Karle, I L, Flippen-Anderson, J L, Agarwalla, S, Balaram, P

“…Structures in four different crystal forms of [Leu1]zervamicin (zervamicin Z-L, Ac-Leu-Ile-Gln-Iva-Ile5-Thr-Aib-Leu-Aib-Hyp10-Gln-Aib-Hyp-Aib-P ro15-Phol,…”
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A Tandem Michael Addition Ring-Closure Route to the Metabotropic Receptor Ligand α-(Hydroxymethyl)glutamic Acid and Its γ-Alkylated Derivatives by Zhang, Jiazhong, Flippen-Anderson, Judith L, Kozikowski, Alan P

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Chemistry and Pharmacology of the Piperidine-Based Analogues of Cocaine. Identification of Potent DAT Inhibitors Lacking the Tropane Skeleton by Kozikowski, Alan P, Araldi, Gian Luca, Boja, John, Meil, William M, Johnson, Kenneth M, Flippen-Anderson, Judith L, George, Clifford, Saiah, Eddine

“…To discover agents that might be useful in the treatment of cocaine abuse, we have chosen to re-explore a class of molecules that was first reported by Clarke…”
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Design, Synthesis, and Monoamine Transporter Binding Site Affinities of Methoxy Derivatives of Indatraline by Gu, Xiao-Hui, Yu, Han, Jacobson, Arthur E, Rothman, Richard B, Dersch, Christina M, George, Clifford, Flippen-Anderson, Judith L, Rice, Kenner C

“…A series of methoxy-containing derivatives of indatraline 13a − f and 17 were synthesized, and their binding affinities for the dopamine, serotonin, and…”
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The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema by Deshpande, Nita, Addess, Kenneth J., Bluhm, Wolfgang F., Merino-Ott, Jeffrey C., Townsend-Merino, Wayne, Zhang, Qing, Knezevich, Charlie, Xie, Lie, Chen, Li, Feng, Zukang, Kramer Green, Rachel, Flippen-Anderson, Judith L., Westbrook, John, Berman, Helen M., Bourne, Philip E.

“…The Protein Data Bank (PDB) is the central worldwide repository for three-dimensional (3D) structure data of biological macromolecules. The Research…”
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Further SAR Studies of Piperidine-Based Analogues of Cocaine. 2. Potent Dopamine and Serotonin Reuptake Inhibitors by Tamiz, Amir P, Zhang, Jianrong, Flippen-Anderson, Judith L, Zhang, Mei, Johnson, Kenneth M, Deschaux, Olivier, Tella, Srihari, Kozikowski, Alan P

“…The synthesis and monoamine transporter activity of additional members of a series of 3,4-disubstituted piperidines (truncated analogues of the WIN series) are…”
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Arteether, a new antimalarial drug: synthesis and antimalarial properties by Brossi, A, Venugopalan, B, Dominguez Gerpe, L, Yeh, H. J. C, Flippen-Anderson, J. L, Buchs, P, Luo, X. D, Milhous, W, Peters, W

“…Arteether (6) has been prepared from dihydroquinghaosu (3) by etherification with ethanol in the presence of Lewis acid and separated from its…”
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Tyrosinium-d-tetrahydroisoquinoline-3-carboxylate 1.5-Hydrate and Tyrosyl-d-tetrahydroisoquinoline-3-carboxamide Hydrate by Deschamps, J. R., Flippen-Anderson, J. L., Moore, C., Cudney, R., George, C.

“…Crystals of the two dipeptide title compounds, Tyr-D-Tic, C19H20N2O4.1.5H2O, and Tyr-D-Tic-NH2, C19H21N3O3.H2O, were prepared by the sitting-drop method…”
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[D-Ala2,D-Leu5]-enkephalin hydrochloride by Deschamps, J R, George, C, Flippen-Anderson, J L

“…The title compound, L-tyrosyl-D-alanyl-glycyl-L-phenyl-alanyl-D-leucine hydrochloride (C29H40N5O7+. Cl-), co-crystallizes with 2-butanone (C4H8O). The…”
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Pharmacological and Behavioral Analysis of the Effects of Some Bivalent Ligand-Based Monoamine Reuptake Inhibitors by Tamiz, Amir P, Bandyopadhyay, Bidhan C, Zhang, Jianrong, Flippen-Anderson, Judith L, Zhang, Mei, Wang, Chen Z, Johnson, Kenneth M, Tella, Srihari, Kozikowski, Alan P

“…Novel piperidine-based bivalent ligands were prepared in enantiomerically pure form and evaluated for their ability to inhibit reuptake of dopamine (DA),…”
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Alpha-helix and mixed 3(10)/alpha-helix in cocrystallized conformers of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-OMe by Karle, I L, Flippen-Anderson, J L, Uma, K, Balaram, H, Balaram, P

“…Two molecules of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-OMe (where Boc is t-butoxycarbonyl and Aib is alpha-aminoisobutyryl) cocrystallize in a triclinic…”
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A diacetylmorphine polymorph by Deschamps, J R, George, C, Flippen-Anderson, J L

“…The title compound, 7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diyl diacetate, C21H23NO5, was crystallized from a solution of its hydrochloride and sodium…”
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A topographically and conformationally constrained, spin-labeled, α-amino acid: crystallographic characterization in peptides by Crisma, M., Deschamps, J.R., George, C., Flippen-Anderson, J.L., Kaptein, B., Broxterman, Q.B., Moretto, A., Oancea, S., Jost, M., Formaggio, F., Toniolo, C.

“…:  2,2,6,6‐Tetramethylpiperidine‐1‐oxyl‐4‐amino‐4‐carboxylic acid (TOAC) is a topographically and conformationally restricted, nitroxide containing,…”
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Absolute configuration of (-)-alpha-acetylmethadol hydrochloride by Flippen-Anderson, J L, George, C

“…beta-[2-(Dimethylamino)propyl]-alpha-ethyl-beta-phenylbenzeneethanol+ ++ acetate ester hydrochloride, C23H32NO2+. Cl-.H2O, M(r) = 407.9, monoclinic, P2(1), a =…”
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Factors Influencing Agonist Potency and Selectivity for the Opioid δ Receptor Are Revealed in Structure−Activity Relationship Studies of the 4-[(N-Substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides by Thomas, James B, Herault, Xavier M, Rothman, Richard B, Atkinson, Robert N, Burgess, Jason P, Mascarella, S. Wayne, Dersch, Christina M, Xu, Heng, Flippen-Anderson, Judith L, George, Clifford F, Carroll, F. Ivy

“…A study of the effect of transposition of the internal nitrogen atom for the adjacent benzylic carbon atom in δ-selective agonists such as BW373U86 (1) and…”
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Three conformers in a crystal of N-Ac-L-Leu-L-Tyr-OMe by Karle, I L, Flippen-Anderson, J L

“…C18H26N2O5, three independent molecules with different conformations, Mr = 350.4, orthorhombic, P2(1)2(1)2(1), a = 16.077 (10), b = 28.935 (18), c = 12.597 (6)…”
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Parallel Zippers Formed by α-Helical Peptide Columns in Crystals of Boc-Aib-Glu(OBzl)-Leu-Aib-Ala-Leu-Aib-Ala-Lys(Z)-Aib-OMe by Karle, Isabella L., Flippen-Anderson, Judith L., Uma, Kuchibhotla, Balaram, Padmanabhan

“…The crystal structure of the decapeptide Boc-Aib-Glu(OBzl)-Leu-Aib-Ala-Leu-Aib-Ala-Lys(Z)-Aib-OMe (where Aib is α-aminoisobutyryl, Boc is t-butoxycarbonyl,…”
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Structure of an ether dimer of deoxydihydroqinghaosu, a potential metabolite of the antimalarial arteether by Flippen-Anderson, J L, George, C, Gilardi, R, Yu, Q S, Dominguez, L, Brossi, A

“…C30H49O7, Mr = 518.69, triclinic, P1, a = 9.013 (2), b = 10.520 (2), c = 15.187 (3) A, alpha = 93.3 (2), beta = 93.73 (1), gamma = 95.88 (2) degrees, V =…”
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