Search Results - "Flint Beal, M"

Mitochondrial dysfunction in Parkinson's disease by Bose, Anindita, Beal, M. Flint

“…Parkinson's disease (PD) is the second most common neurodegenerative disease. About 2% of the population above the age of 60 is affected by the disease. The…”
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Mitochondrial Diseases of the Brain by Chaturvedi, Rajnish K, Flint Beal, M

“…Neurodegenerative disorders are debilitating diseases of the brain, characterized by behavioral, motor and cognitive impairments. Ample evidence underpins…”
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PGC-1α, mitochondrial dysfunction, and Huntington's disease by Johri, Ashu, Chandra, Abhishek, Flint Beal, M.

“…The constant high energy demand of neurons makes them rely heavily on their mitochondria. Dysfunction of mitochondrial energy metabolism leads to reduced ATP…”
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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases by Beal, M. Flint, Lin, Michael T

“…Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Mitochondria are critical regulators of cell…”
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Mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell models of Parkinson's disease by Bose, Anindita, Beal, M. Flint

“…Parkinson's disease (PD) is the second most common neurodegenerative disease. Two percent of the population above the age of 60 is affected by the disease. The…”
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Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications by Banerjee, Rebecca, Beal, M. Flint, Thomas, Bobby

“…Autophagy is a highly conserved intracellular pathway involved in the elimination of proteins and organelles by lysosomes. Known originally as an adaptive…”
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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing by Cunnane, Stephen C., Trushina, Eugenia, Morland, Cecilie, Prigione, Alessandro, Casadesus, Gemma, Andrews, Zane B., Beal, M. Flint, Bergersen, Linda H., Brinton, Roberta D., de la Monte, Suzanne, Eckert, Anne, Harvey, Jenni, Jeggo, Ross, Jhamandas, Jack H., Kann, Oliver, la Cour, Clothide Mannoury, Martin, William F., Mithieux, Gilles, Moreira, Paula I., Murphy, Michael P., Nave, Klaus-Armin, Nuriel, Tal, Oliet, Stéphane H. R., Saudou, Frédéric, Mattson, Mark P., Swerdlow, Russell H., Millan, Mark J.

“…The brain requires a continuous supply of energy in the form of ATP, most of which is produced from glucose by oxidative phosphorylation in mitochondria,…”
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Mitochondria take center stage in aging and neurodegeneration by Beal, M. Flint

“…A critical role of mitochondrial dysfunction and oxidative damage has been hypothesized in both aging and neurodegenerative diseases. Much of the evidence has…”
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Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease by Kriks, Sonja, Shim, Jae-Won, Piao, Jinghua, Ganat, Yosif M., Wakeman, Dustin R., Xie, Zhong, Carrillo-Reid, Luis, Auyeung, Gordon, Antonacci, Chris, Buch, Amanda, Yang, Lichuan, Beal, M. Flint, Surmeier, D. James, Kordower, Jeffrey H., Tabar, Viviane, Studer, Lorenz

“…A new strategy for derivation of human midbrain dopamine neurons from pluripotent cells was developed; transplantation of the neurons in mice, rats and…”
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Impaired mitochondrial function in psychiatric disorders by Manji, Husseini, Kato, Tadafumi, Di Prospero, Nicholas A., Ness, Seth, Beal, M. Flint, Krams, Michael, Chen, Guang

“…Key Points Major psychiatric illnesses such as mood disorders and schizophrenia are common, chronic, recurrent mental illnesses that affect the lives and…”
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Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease by Yang, Yun, Tapias, Victor, Acosta, Diana, Xu, Hui, Chen, Huanlian, Bhawal, Ruchika, Anderson, Elizabeth T., Ivanova, Elena, Lin, Hening, Sagdullaev, Botir T., Chen, Jianer, Klein, William L., Viola, Kirsten L., Gandy, Sam, Haroutunian, Vahram, Beal, M. Flint, Eliezer, David, Zhang, Sheng, Gibson, Gary E.

“…Abnormalities in brain glucose metabolism and accumulation of abnormal protein deposits called plaques and tangles are neuropathological hallmarks of…”
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Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis by Henchcliffe, Claire, Beal, M Flint

“…Mitochondrial dysfunction and oxidative stress have been strongly implicated in the pathogenesis of Parkinson disease (PD), and the products of several…”
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PGC-1α, Sirtuins and PARPs in Huntington’s Disease and Other Neurodegenerative Conditions: NAD+ to Rule Them All by Lloret, Alejandro, Beal, M. Flint

“…In this review, we summarize the available published information on the neuroprotective effects of increasing nicotinamide adenine dinucleotide (NAD + ) levels…”
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Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease by Reddy, P. Hemachandra, Beal, M. Flint

“…Recent studies of postmortem brains from Alzheimer's disease (AD) patients and transgenic mouse models of AD suggest that oxidative damage, induced by amyloid…”
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Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations by Chen, Qiuying, Kirk, Kathryne, Shurubor, Yevgeniya I., Zhao, Dazhi, Arreguin, Andrea J., Shahi, Ifrah, Valsecchi, Federica, Primiano, Guido, Calder, Elizabeth L., Carelli, Valerio, Denton, Travis T., Beal, M. Flint, Gross, Steven S., Manfredi, Giovanni, D'Aurelio, Marilena

“…Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG)…”
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Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease by Kim, Jinho, Moody, Jennifer P., Edgerly, Christina K., Bordiuk, Olivia L., Cormier, Kerry, Smith, Karen, Beal, M. Flint, Ferrante, Robert J.

“…Although a direct causative pathway from the gene mutation to the selective neostriatal neurodegeneration remains unclear in Huntington's disease (HD), one…”
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Combination therapy with Coenzyme Q₁₀ and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's Diseases by Yang, Lichuan, Calingasan, Noel Y, Wille, Elizabeth J, Cormier, Kerry, Smith, Karen, Ferrante, Robert J, Flint Beal, M

“…Coenzyme Q₁₀ (CoQ₁₀) and creatine are promising agents for neuroprotection in neurodegenerative diseases via their effects on improving mitochondrial function…”
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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery by Yang, Yufeng, Ouyang, Yingshi, Yang, Lichuan, Beal, M. Flint, McQuibban, Angus, Vogel, Hannes, Lu, Bingwei

“…Mitochondria form dynamic tubular networks that undergo frequent morphological changes through fission and fusion, the imbalance of which can affect cell…”
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Mitochondrial Approaches for Neuroprotection by Chaturvedi, Rajnish K., Beal, M. Flint

“…A large body of evidence from postmortem brain tissue and genetic analysis in humans and biochemical and pathological studies in animal models (transgenic and…”
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Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease by Johri, Ashu, Calingasan, Noel Y., Hennessey, Thomas M., Sharma, Abhijeet, Yang, Lichuan, Wille, Elizabeth, Chandra, Abhishek, Beal, M. Flint

“…There is substantial evidence that impairment of peroxisome proliferator-activated receptor (PPAR)-γ-coactivator 1α (PGC-1α) levels and activity play an…”
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