Search Results - "Flint, Robert B"

Prediction of glomerular filtration rate maturation across preterm and term neonates and young infants using inulin as marker by Wu, Yunjiao, Allegaert, Karel, Flint, Robert B., Simons, Sinno H. P., Krekels, Elke H. J., Knibbe, Catherijne A. J., Völler, Swantje

“…Describing glomerular filtration rate (GFR) maturation across the heterogeneous population of preterm and term neonates and infants is important to predict the…”
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Oral Ibuprofen Is More Effective than Intravenous Ibuprofen for Closure of a Patent Ductus Arteriosus: Can Pharmacokinetic Modeling Help Us to Understand Why? by Smit, Cornelis, Engbers, Aline G J, Samiee-Zafarghandy, Samira, van Donge, Tamara, Simons, Sinno H P, Flint, Robert B, Pfister, Marc, Knibbe, Catherijne A J, van den Anker, John N

“…Oral ibuprofen is more effective than intravenous (IV) ibuprofen for closure of a patent ductus arteriosus (PDA). This study explored whether higher…”
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Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants by Flint, Robert B, Roofthooft, Daniella W, van Rongen, Anne, van Lingen, Richard A, van den Anker, Johannes N, van Dijk, Monique, Allegaert, Karel, Tibboel, Dick, Knibbe, Catherijne A J, Simons, Sinno H P

“…Background Exposure to acetaminophen and its metabolites in very-preterm infants is partly unknown. We investigated the exposure to acetaminophen and its…”
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Neonatal Clinical Pharmacology by Allegaert, Karel, Yalcin, Nadir, Flint, Robert B, Simons, Sinno H P

“…Similar to other populations, care of neonates strongly relies on robust guidance on neonatal pharmacotherapy, covering an age-appropriate drug formulation, an…”
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Model-Informed Precision Dosing of Antibiotics in Pediatric Patients: A Narrative Review by Abdulla, Alan, Edwina, Angela E, Flint, Robert B, Allegaert, Karel, Wildschut, Enno D, Koch, Birgit C P, de Hoog, Matthijs

“…Optimal pharmacotherapy in pediatric patients with suspected infections requires understanding and integration of relevant data on the antibiotic, bacterial…”
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Risk for neonatal hypoglycaemia and bradycardia after beta-blocker use during pregnancy or lactation: a systematic review and meta-analysis protocol by de Bruin, Rosalie, van Dalen, Sarah L, Franx, Shamaya J, Simons, Sinno HP, Flint, Robert B, van den Bosch, Gerbrich E

“…IntroductionBeta-blockers are often used during pregnancy to treat diseases such as pre-existing hypertension, arrhythmias or pregnancy-related hypertension…”
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Protocol: Pentoxifylline optimal dose finding trial in preterm neonates with suspected late onset sepsis (PTX-trial) by Kurul, Serife, Taal, H Rob, Flint, Robert B, Mazela, Jan, Reiss, Irwin K M, Allegaert, Karel, Simons, Sinno H P

“…Late onset sepsis is a leading cause of death and morbidity in preterm infants. Despite optimal antibiotic treatment, sepsis related mortality and morbidity is…”
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Maternal, fetal, neonatal and breastmilk flecainide concentration during maternal therapy and lactation: a case report by van der Zande, Johanna A, Cornette, Jérôme M J, Roos-Hesselink, Jolien W, Flint, Robert B

“…Mothers requiring the antiarrhythmic agent flecainide are often advised not to breastfeed, because of the lack of data concercing neonatal effects and…”
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Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review by de Klerk, Johan C. A., Engbers, Aline G. J., van Beek, Floor, Flint, Robert B., Reiss, Irwin K. M., Völler, Swantje, Simons, Sinno H. P.

“…The optimal management strategy for patent ductus arteriosus in preterm infants remains a topic of debate. Available evidence for a treatment strategy might be…”
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Precision Dosing of Doxapram in Preterm Infants Using Continuous Pharmacodynamic Data and Model-Based Pharmacokinetics: An Illustrative Case Series by Poppe, Jarinda A, van Weteringen, Willem, Sebek, Lotte L G, Knibbe, Catherijne A J, Reiss, Irwin K M, Simons, Sinno H P, Flint, Robert B

“…Current drug dosing in preterm infants is standardized, mostly based on bodyweight. Still, covariates such as gestational and postnatal age may importantly…”
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Cerebral Oxygenation and Activity During Surgical Repair of Neonates With Congenital Diaphragmatic Hernia: A Center Comparison Analysis by Costerus, Sophie A, Hendrikx, Dries, IJsselmuiden, Joen, Zahn, Katrin, Perez-Ortiz, Alba, Van Huffel, Sabine, Flint, Robert B, Caicedo, Alexander, Wijnen, René, Wessel, Lucas, de Graaff, Jurgen C, Tibboel, Dick, Naulaers, Gunnar

“…Neonatal brain monitoring is increasingly used due to reports of brain injury perioperatively. Little is known about the effect of sedatives (midazolam) and…”
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Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review by van de Vusse, Dylan, Mian, Paola, Schoenmakers, Sam, Flint, Robert B., Visser, Willy, Allegaert, Karel, Versmissen, Jorie

“…Purpose Antihypertensive drugs are among the most prescribed drugs during pregnancy. Methyldopa, labetalol, and nifedipine have been perceived safe to use…”
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Target Drug Exposure Attainment in Children: How to Get from Better to Best by Flint, Robert B., Allegaert, Karel

“…The combination of both allows straightforward comparison with reference target ranges. [...]923 of 1642 patients were excluded as the measured concentration…”
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Correction to: Comment on: “Preterm Physiologically Based Pharmacokinetic Model, Part I and Part II” by Völler, Swantje, Flint, Robert B., Simons, Sinno H. P., Knibbe, Catherijne A. J.

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An Update of Pharmacological Management in Children with Functional Constipation by de Geus, Anna, Koppen, Ilan J. N., Flint, Robert B., Benninga, Marc A., Tabbers, Merit M.

“…Functional constipation is a common problem in childhood worldwide and has a great impact on social, physical, and emotional functioning of affected children…”
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Pre- and Postnatal Maturation are Important for Fentanyl Exposure in Preterm and Term Newborns: A Pooled Population Pharmacokinetic Study by Wu, Yunjiao, Völler, Swantje, Flint, Robert B., Simons, Sinno H. P., Allegaert, Karel, Fellman, Vineta, Knibbe, Catherijne A. J.

“…Background and Objective Fentanyl is an opioid commonly used to prevent and treat severe pain in neonates; however, its use is off label and mostly based on…”
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Dried blood spot analysis for the quantification of vancomycin and creatinine using liquid chromatography – tandem mass spectrometry: Method development and validation by Bahmany, Soma, Hassanzai, Moska, Flint, Robert B., van Onzenoort, Hein A.W., de Winter, Brenda C.M., Koch, Birgit C.P.

“…•Dried blood spot (DBS) sampling is a sustainable alternative to venipuncture which can be performed at home.•A highly accurate and rapid assay for the…”
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Perinatal outcomes after in-utero exposure to beta-blockers in women with heart disease: Data from the ESC EORP registry of pregnancy and cardiac disease (ROPAC) by Ramlakhan, Karishma P., Roos-Hesselink, Jolien W., Basso, Thomas, Greenslade, Jaimi, Flint, Robert B., Krieger, Eric V., Shotan, Avraham, Budts, Werner, De Backer, Julie, Hall, Roger, Johnson, Mark R., Parsonage, William A.

“…Beta-blockers are commonly used drugs during pregnancy, especially in women with heart disease, and are regarded as relatively safe although evidence is…”
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A Pooled Population Pharmacokinetic Study of Oral and Intravenous Administration of Clavulanic Acid in Neonates and Infants: Targeting Effective Beta-Lactamase Inhibition by Schouwenburg, Stef, Keij, Fleur M, Tramper-Stranders, Gerdien A, Kornelisse, René F, Reiss, Irwin K M, de Cock, Pieter A J G, Dhont, Evelyn, Watt, Kevin M, Muller, Anouk E, Flint, Robert B, Koch, Birgit C P, Allegaert, Karel, Preijers, Tim

“…Data published on the oral clavulanic acid pharmacokinetics in the pediatric population is lacking. This research aimed to describe clavulanic acid disposition…”
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Grading the level of evidence of neonatal pharmacotherapy: midazolam and phenobarbital as examples by Mahoney, Liam, Raffaeli, Genny, Beken, Serdar, Ünal, Sezin, Kotidis, Charalampos, Cavallaro, Giacomo, Garrido, Felipe, Bhatt, Aomesh, Dempsey, Eugene M., Allegaert, Karel, Simons, Sinno H. P., Flint, Robert B., Smits, Anne

“…Background Many drugs are used off-label or unlicensed in neonates. This does not mean they are used without evidence or knowledge. We aimed to apply and…”
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