Search Results - "Flint, David J."

Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin by Brown, Sarah D, Nativo, Paola, Smith, Jo-Ann, Stirling, David, Edwards, Paul R, Venugopal, Balaji, Flint, David J, Plumb, Jane A, Graham, Duncan, Wheate, Nial J

“…The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting…”
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Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis by Beattie, James, Allan, Gordon J, Lochrie, Jennifer D, Flint, David J

“…The six members of the insulin-like growth factor-binding protein family (IGFBP-1-6) are important components of the IGF (insulin-like growth factor) axis. In…”
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The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitro by Wright, Catherine S., Pollok, Simone, Flint, David J., Brandner, Johanna M., Martin, Patricia E.M.

“…Significant increases in skin wound healing rates occur by reducing connexin‐mediated communication (CMC). Gap27, a connexin (Cx) mimetic peptide targeted to…”
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Epithelial injury induces an innate repair mechanism linked to cellular senescence and fibrosis involving IGF-binding protein-5 by Allan, Gordon J, Beattie, James, Flint, David J

“…Fibrosis is associated with epithelial repair. It involves the activation of fibroblasts, increased production of extracellular matrix proteins and…”
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Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland by Flint, David J, Travers, Maureen T, Barber, Michael C, Binart, Nadine, Kelly, Paul A

“…We have developed a mouse model of diet-induced obesity that shows numerous abnormalities relating to mammary gland function. Animals ate approximately 40%…”
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IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response by Sureshbabu, Angara, Okajima, Hiroshi, Yamanaka, Daisuke, Shastri, Surya, Tonner, Elizabeth, Rae, Colin, Szymanowska, Malgorzata, Shand, John H, Takahashi, Shin-Ichiro, Beattie, James, Allan, Gordon J, Flint, David J

“…Fibrosis involves activation of fibroblasts, increased production of collagen and fibronectin and transdifferentiation into contractile myofibroblasts. The…”
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Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice by Tonner, Elizabeth, Barber, Michael C, Allan, Gordon J, Beattie, James, Webster, John, Whitelaw, C Bruce A, Flint, David J

“…We have previously demonstrated that IGFBP-5 production by mammary epithelial cells increases dramatically during involution of the mammary gland. To…”
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Post-weaning increases in the milk-fat globule EGF-factor VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells by Nakatani, Hajime, Yasueda, Takehiko, Oshima, Kenzi, Okajima, Tetsuya, Nadano, Daita, Flint, David J, Matsuda, Tsukasa

“…Milk fat globules (MFGs) secreted by lactating mammary gland are unique lipid surrounded by a phospholipid bi-layer. We report here post-weaning changes in MFG…”
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Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells by Marshman, Emma, Green, Kirsty A, Flint, David J, White, Anne, Streuli, Charles H, Westwood, Melissa

“…Insulin-like growth factors (IGFs) are important survival signals that can protect a range of cell types from apoptosis. Although IGF bioavailability is…”
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Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis by John, Alison E., Graves, Rebecca H., Pun, K. Tao, Vitulli, Giovanni, Forty, Ellen J., Mercer, Paul F., Morrell, Josie L., Barrett, John W., Rogers, Rebecca F., Hafeji, Maryam, Bibby, Lloyd I., Gower, Elaine, Morrison, Valerie S., Man, Yim, Roper, James A., Luckett, Jeni C., Borthwick, Lee A., Barksby, Ben S., Burgoyne, Rachel A., Barnes, Rory, Le, Joelle, Flint, David J., Pyne, Susan, Habgood, Anthony, Organ, Louise A., Joseph, Chitra, Edwards-Pritchard, Rochelle C., Maher, Toby M., Fisher, Andrew J., Gudmann, Natasja Stæhr, Leeming, Diana J., Chambers, Rachel C., Lukey, Pauline T., Marshall, Richard P., Macdonald, Simon J. F., Jenkins, R. Gisli, Slack, Robert J.

“…The αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of…”
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Insulin-like Growth Factor-binding Protein-5 Activates Plasminogen by Interaction with Tissue Plasminogen Activator, Independently of Its Ability to Bind to Plasminogen Activator Inhibitor-1, Insulin-like Growth Factor-I, or Heparin by Sorrell, Alice M., Shand, John H., Tonner, Elizabeth, Gamberoni, Matteo, Accorsi, Pier A., Beattie, James, Allan, Gordon J., Flint, David J.

“…Transgenic mice expressing IGFBP-5 in the mammary gland exhibit increased cell death and plasmin generation. Because IGFBP-5 has been reported to bind to…”
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Insulin-like growth factor binding protein (IGFBP)-5 is upregulated during both differentiation and apoptosis in primary cultures of mouse mammary epithelial cells by Lochrie, Jennifer D., Phillips, Kirsten, Tonner, Elizabeth, Flint, David J., Allan, Gordon J., Price, Nicholas C., Beattie, James

“…We have previously demonstrated that insulin‐like growth factor binding protein‐5 (IGFBP‐5) is upregulated following treatment of the mouse mammary epithelial…”
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Specific Amino Acid Substitutions Determine the Differential Contribution of the N- and C-terminal Domains of Insulin-like Growth Factor (IGF)-binding Protein-5 in Binding IGF-I by Shand, John H, Beattie, James, Song, Hyuk, Phillips, Kirsten, Kelly, Sharon M, Flint, David J, Allan, Gordon J

“…We have previously reported that two highly conserved amino acids in the C-terminal domain of rat insulin-like growth factor-binding protein (IGFBP)-5, Gly 203…”
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Evaluation of anionic half generation 3.5–6.5 poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drug cisplatin by Kirkpatrick, Gordon J., Plumb, Jane A., Sutcliffe, Oliver B., Flint, David J., Wheate, Nial J.

“…Aquated cisplatin was added to half-generation PAMAM dendrimers and the resultant complexes were purified by centrifuge. The drug–dendrimer complexes were then…”
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The role of IGFBP-5 in mammary gland development and involution by Allan, Gordon J., Beattie, James, Flint, David J.

“…Insulin-like growth factor-I (IGF-I) plays an important role as a survival factor during mammary gland development and remodelling during involution of the…”
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Effects of growth hormone and prolactin on adipose tissue development and function by Flint, David J, Binart, Nadine, Kopchick, John, Kelly, Paul

“…GH and PRL are both implicated in adipose tissue development. Whilst direct effects of GH have been clearly demonstrated, direct effects of PRL have been…”
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Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis by Chin, Chiahsuan, Ravichandran, Ranjithkumar, Sanborn, Kristina, Fleming, Timothy, Wheatcroft, Stephen B., Kearney, Mark T., Tokman, Sofya, Walia, Rajat, Smith, Michael A., Flint, David J., Mohanakumar, Thalachallour, Bremner, Ross M., Sureshbabu, Angara

“…Accumulation of senescent cells contributes to age-related diseases including idiopathic pulmonary fibrosis (IPF). Insulin-like growth factor binding proteins…”
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Molecular recognition characteristics in the insulin-like growth factor (IGF)-insulin-like growth factor binding protein -3/5 (IGFBP-3/5) heparin axis by Beattie, James, Phillips, Kirsten, Shand, John H, Szymanowska, Malgorzata, Flint, David J, Allan, Gordon J

“…Insulin-like growth factor binding proteins (IGFBPs) -3 and -5 are known to interact with various components of the extracellular matrix (ECM; e.g. heparin and…”
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Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2 by Slack, Robert J, Hafeji, Maryam, Rogers, Rebecca, Ludbrook, Steve B, Marshall, John F, Flint, David J, Pyne, Susan, Denyer, Jane C

“…A20FMDV2 is a peptide derived from the foot-and-mouth disease virus with a high affinity and selectivity for the alpha-v beta-6 (αvβ6)…”
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Insulin-like growth factor binding proteins and mammary gland development by Sureshbabu, Angara, Tonner, Elizabeth, Flint, David J

“…Mammary gland development is dependent upon insulin-like growth factors (IGFs) as survival factors. The actions of the IGFs are modulated by a family of…”
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