Search Results - "Flinn, Jane M."

Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye by Thompson, Richard B., Reffatto, Valentina, Bundy, Jacob G., Kortvely, Elod, Flinn, Jane M., Lanzirotti, Antonio, Jones, Emrys A., McPhail, David S., Fearn, Sarah, Boldt, Karsten, Ueffing, Marius, Ratu, Savanjeet Guy Singh, Pauleikhoff, Laurenz, Bird, Alan C., Lengyel, Imre

“…Significance Proteins and lipids accumulating in deposits external to the retinal pigment epithelium (RPE) represent a barrier to metabolic exchange between…”
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A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology by Lippi, Stephen L P, Smith, Meghann L, Flinn, Jane M

“…The brains of those with Alzheimer's disease have amyloid and tau pathology; thus, mice modeling AD should have both markers. In this study, we characterize…”
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Wheel-Running Behavior Is Negatively Impacted by Zinc Administration in a Novel Dual Transgenic Mouse Model of AD by Lippi, Stephen L. P., Kakalec, Peter A., Smith, Meghann L., Flinn, Jane M.

“…Alzheimer’s disease (AD) is a neurocognitive disorder that impacts both the brain and behavior. Metal ions, including zinc (Zn), have been seen to play an…”
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Transfusion with Blood Plasma from Young Mice Affects rTg4510 Transgenic Tau Mice Modeling of Alzheimer's Disease by Hernandez, Carlos M, Barkey, Rachel E, Craven, Kristen M, Pedemonte, Karin A, Alisantosa, Bernadette, Sanchez, Jonathan O, Flinn, Jane M

“…Alzheimer's disease (AD) is characterized by the buildup of plaques and tangles in the brain. Tangles are formed when the stabilizing protein, tau, becomes…”
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White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease by Dimopoulos, Thalia T, Lippi, Stephen L P, Davila, Jorge Fernandez, Barkey, Rachel E, Doherty, Erin N, Flinn, Jane M

“…Alzheimer’s Disease (AD) is characterized by cognitive impairment and the presence of amyloid-β (Aβ) plaques and tau tangles. This study was conducted to…”
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High concentration of zinc in sub-retinal pigment epithelial deposits by Lengyel, Imre, Flinn, Jane M., Pető, Tünde, Linkous, David H., Cano, Katherine, Bird, Alan C., Lanzirotti, Antonio, Frederickson, Christopher J., van Kuijk, Frederik J.G.M.

“…One of the hallmarks of age-related macular degeneration (AMD), the leading cause of blindness in the elderly in Western societies, is the accumulation of…”
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Localization of Free and Bound Metal Species through X-Ray Synchrotron Fluorescence Microscopy in the Rodent Brain and Their Relation to Behavior by Neely, Caroline L C, Lippi, Stephen L P, Lanzirotti, Antonio, Flinn, Jane M

“…Biometals in the brain, such as zinc, copper, and iron, are often discussed in cases of neurological disorders; however, these metals also have important…”
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Zinc Exacerbates Tau Pathology in a Tau Mouse Model by Craven, Kristen M, Kochen, William R, Hernandez, Carlos M, Flinn, Jane M

“…Hyperphosphorylated tau protein is a key pathology in Alzheimer's disease (AD), frontotemporal dementia, chronic traumatic encephalopathy, and Parkinson's…”
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Circadian wheel running behavior is altered in an APP/E4 mouse model of late onset Alzheimer's disease by Boggs, Katelyn N., Kakalec, Peter A., Smith, Meghann L., Howell, Stefanie N., Flinn, Jane M.

“…Circadian rhythms are altered in several diseases associated with aging, one of which is Alzheimer's disease (AD). One example of a circadian rhythm is the…”
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Participation in Active Singing Leads to Cognitive Improvements in Individuals with Dementia by Maguire, Linda E., Wanschura, Patricia B., Battaglia, Margorie M., Howell, Stefanie N., Flinn, Jane M.

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Both Genetic and Environmental Changes Can Enhance Learning and Memory by Flinn, Jane M

“…This review discusses two papers from the same lab that directly compared the effects of genetic enhancement with environmental enrichment on learning and…”
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Correlations in distribution and concentration of calcium, copper and iron with zinc in isolated extracellular deposits associated with age-related macular degeneration by Flinn, Jane M, Kakalec, Peter, Tappero, Ryan, Jones, Blair, Lengyel, Imre

“…Zinc (Zn) is abundantly enriched in sub-retinal pigment epithelial (RPE) deposits, the hallmarks of age-related macular degeneration (AMD), and is thought to…”
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Localization of the zinc binding tubulin polymerization promoting protein in the mice and human eye by Tripon, Robert G., Oláh, Judit, Nasir, Tajwar, Csincsik, Lajos, Li, Chee Lok, Szunyogh, Sándor, Gong, Haiyan, Flinn, Jane M., Ovádi, Judit, Lengyel, Imre

“…[Display omitted] •TPPP/p25 is expressed in oligodendrocytes and some amacrine cell bodies in the eye.•In the inner plexiform layer of the retina TPPP/p25 is…”
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The effect of metals on spatial memory in a transgenic mouse model of Alzheimer's disease by Railey, Angela M, Groeber, Caitlin M, Flinn, Jane M

“…The amyloid-β protein (Aβ) is a metalloprotein with affinity for the metal ions zinc (Zn), copper (Cu), and iron (Fe), which are found in high concentrations…”
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Evidence That the ZNT3 Protein Controls the Total Amount of Elemental Zinc in Synaptic Vesicles by Linkous, David H, Flinn, Jane M, Koh, Jae Y, Lanzirotti, Antonio, Bertsch, Paul M, Jones, Blair F, Giblin, Leonard J, Frederickson, Christopher J

“…The ZNT3 protein decorates the presynaptic vesicles of central neurons harboring vesicular zinc, and deletion of this protein removes staining for zinc…”
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Indications of Reduced Prefrontal Cortical Function in Chronically Homeless Adults by Davidson, Dale, Chrosniak, Linda D., Wanschura, Patricia, Flinn, Jane M.

“…This study investigated why some homeless individuals seem unable to transition towards self-reliance, following traditional supportive services. It was…”
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Spatial memory deficits in a mouse model of late-onset Alzheimer's disease are caused by zinc supplementation and correlate with amyloid-beta levels by Flinn, Jane M, Bozzelli, P Lorenzo, Adlard, Paul A, Railey, Angela M

“…Much of the research in Alzheimer's disease (AD) that uses mouse models focuses on the early-onset form of the disease, which accounts for less than 5% of…”
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Alterations in fear response and spatial memory in pre- and post-natal zinc supplemented rats: Remediation by copper by Railey, Angela M, Micheli, Teresa L, Wanschura, Patricia B, Flinn, Jane M

“…Abstract The role of zinc in the nervous system is receiving increased attention. At a time when dietary fortification and supplementation have increased the…”
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Human ApoE ε4 alters circadian rhythm activity, IL-1β, and GFAP in CRND8 mice by Graybeal, John J, Bozzelli, P Lorenzo, Graybeal, Lacey L, Groeber, Caitlin M, McKnight, Patrick E, Cox, Daniel N, Flinn, Jane M

“…Disruptions to daily living, inflammation, and astrogliosis are characteristics of Alzheimer's disease. Thus, circadian rhythms, nest construction, IL-1β and…”
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The effects of enhanced zinc on spatial memory and plaque formation in transgenic mice by Linkous, David H, Adlard, Paul A, Wanschura, Patricia B, Conko, Kathryn M, Flinn, Jane M

“…There is considerable evidence suggesting that metals play a central role in the pathogenesis of Alzheimer's disease. Reports suggest that elevated dietary…”
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