Search Results - "Fling, Mary E."

Genetic variations in HLA-B region and hypersensitivity reactions to abacavir by Hetherington, Seth, Hughes, Arlene R, Mosteller, Michael, Shortino, Denise, Baker, Katherine L, Spreen, William, Lai, Eric, Davies, Kirstie, Handley, Abigail, Dow, David J, Fling, Mary E, Stocum, Michael, Bowman, Clive, Thurmond, Linda M, Roses, Allen D

“…Hypersensitivity to abacavir affects about 4% of patients who receive the drug for HIV-1 infection. We did a retrospective, case-control study to identify…”
Get full text

Site-specific Conjugation on Serine → Cysteine Variant Monoclonal Antibodies by Stimmel, Julie B., Merrill, Barbara M., Kuyper, Lee F., Moxham, Cary P., Hutchins, Jeff T., Fling, Mary E., Kull, Frederick C.

“…We have engineered a cysteine residue at position 442 (EU/OU numbering) in the third constant domain (CH3) of the heavy chain of several IgGs with different…”
Get full text

X-ray Crystallographic Studies of Candida albicans Dihydrofolate Reductase by Whitlow, Marc, Howard, Andrew J., Stewart, David, Hardman, Karl D., Kuyper, Lee F., Baccanari, David P., Fling, Mary E., Tansik, Robert L.

“…The recent rise in systemic fungal infections has created a need for the development of new antifungal agents. As part of an effort to provide therapeutically…”
Get full text

A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma by PILLAI, Sreekumar G, COUSENS, Diane J, SARAU, Henry M, SCHMIDT, Dulcie B, SPRANKLE, Catherine S, BLUMENTHAL, Malcolm N, VESTBO, Jorgen, KENNEDY-WILSON, Karen, WIXTED, William E, WAGNER, Michael J, ANDERSON, Wayne H, IGNAR, Diane M, BARNES, Ashley A, BUCKLEY, Peter T, CHIANO, Mathias N, HOSKING, Louise K, CAMERON, Lee-Ann, FLING, Mary E, FOLEY, James J, GREEN, Andrew

“…Cysteinyl leukotrienes (CYSLTR) are potent biological mediators in the pathophysiology of asthma for which two receptors have been characterized, CYSLTR1 and…”
Get full text

In vitro characterization of a human calcitonin receptor gene polymorphism by Wolfe, 3rd, Lawrence A, Fling, Mary E, Xue, Zhengyu, Armour, Susan, Kerner, Sandra A, Way, James, Rimele, Tom, Cox, Richard F

“…Calcitonin is a 32 amino acid peptide hormone that inhibits bone resorption by stimulating calcitonin receptors (CTR) located on the surfaces of osteoclasts. A…”
Get more information

X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex by Whitlow, M, Howard, A J, Stewart, D, Hardman, K D, Kuyper, L F, Baccanari, D P, Fling, M E, Tansik, R L

“…The recent rise in systemic fungal infections has created a need for the development of new antifungal agents. As part of an effort to provide therapeutically…”
Get full text

In vitro characterization of a human calcitonin receptor gene polymorphism by WOLFE, Lawrence A, FLING, Mary E, ZHENGYU XUE, ARMOUR, Susan, KERNER, Sandra A, WAY, James, RIMELE, Tom, COX, Richard F

Get full text

Molecular Mechanisms of Resistance to Trimethoprim by Burchall, James J., Lynn P. Elwell, Mary E. Fling

“…Resistance to inhibitors of dihydrofolate reductase arises from a variety of mechanisms involving enzyme alteration, cellular impermeability, enzyme…”
Get full text

The nucleotide sequence of the trimethoprim-resistant dihydrofolate reductase gene harbored by Tn7 by Fling, Mary E., Richards, Cindy

“…The complete nucleotide sequence of the type I dihydrofolate reductase gene from Tn7 was determined. The structural gene coded for a polypeptide of 157 amino…”
Get full text

Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate by Fling, M E, Kopf, J, Tamarkin, A, Gorman, J A, Smith, H A, Koltin, Y

“…The pathogenic yeast, Candida albicans, is insensitive to the anti-mitotic drug, benomyl, and to the dihydrofolate reductase inhibitor, methotrexate. Genes…”
Get more information

Characterization of plasmid pAZ1 and the type III dihydrofolate reductase gene by Fling, M E, Kope, J, Richards, C

“…The plasmid pAZ1, which determines trimethoprim and sulfonamide resistance, was characterized by restriction endonuclease mapping. The restriction map was…”
Get more information

Nucleotide sequence of the dihydrofolate reductase gene of Saccharomyces cerevisiae by Fling, M E, Kopf, J, Richards, C A

“…The nucleotide sequence of a DNA fragment that contained the Saccharomyces cerevisiae gene DFR coding for dihydrofolate reductase (DHFR) was determined. The…”
Get more information

Trimethoprim Resistance In Multiple Genera of Enterobacteriaceae at a U.S. Hospital: Spread of the Type II Dihydrofolate Reductase Gene by a Single Plasmid by Mayer, Kenneth H., Fling, Mary E., Hopkins, John D., O'Brien, Thomas F.

“…The percentage of clinical isolates of several species of Enterobacteriaceae, particularly Escherichia coli and Klebsiella pneumoniae, resistant to…”
Get full text