Search Results - "Flies, Sarah"

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells by Azuma, Takeshi, Yao, Sheng, Zhu, Gefeng, Flies, Andrew S., Flies, Sarah J., Chen, Lieping

“…B7-H1 is an immunoglobulin-like immune suppressive molecule broadly detectable on the majority of human and rodent cancers, and its functions have been…”
Get full text

B7-H5 costimulates human T cells via CD28H by Zhu, Yuwen, Yao, Sheng, Iliopoulou, Bettina P., Han, Xue, Augustine, Mathew M., Xu, Haiying, Phennicie, Ryan T., Flies, Sarah J., Broadwater, Megan, Ruff, William, Taube, Janis M., Zheng, Linghua, Luo, Liqun, Zhu, Gefeng, Chen, Jianzhu, Chen, Lieping

“…The B7/CD28 family has profound modulatory effects in immune responses and constitutes an important target for the development of novel therapeutic drugs…”
Get full text

PD-1 on dendritic cells impedes innate immunity against bacterial infection by Yao, Sheng, Wang, Shengdian, Zhu, Yuwen, Luo, Liqun, Zhu, Gefeng, Flies, Sarah, Xu, Haiying, Ruff, William, Broadwater, Megan, Choi, In-Hak, Tamada, Koji, Chen, Lieping

“…Programmed death one (PD-1) is an inducible molecule belonging to the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes and plays…”
Get full text

B7-H4–deficient mice display augmented neutrophil-mediated innate immunity by Zhu, Gefeng, Augustine, Mathew M., Azuma, Takeshi, Luo, Liqun, Yao, Sheng, Anand, Sudarshan, Rietz, A. Cecilia, Huang, Jiaqiang, Xu, Haiying, Flies, Andrew S., Flies, Sarah J., Tamada, Koji, Colonna, Marco, van Deursen, Jan M.A., Chen, Lieping

“…B7-H4 is an immunoglobulin superfamily molecule and shown to be inhibitory for T-cell responses. To explore physiologic roles of B7-H4, we created…”
Get full text

Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease by Xu, Yanhui, Flies, Andrew S., Flies, Dallas B., Zhu, Gefeng, Anand, Sudarshan, Flies, Sarah J., Xu, Haiying, Anders, Robert A., Hancock, Wayne W., Chen, Lieping, Tamada, Koji

“…Decoy lymphotoxin β receptor (LTβR) has potent immune inhibitory activities and thus represents a promising biologic for the treatment of inflammation,…”
Get full text

Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy by Tsushima, Fumihiko, Yao, Sheng, Shin, Tahiro, Flies, Andrew, Flies, Sarah, Xu, Haiying, Tamada, Koji, Pardoll, Drew M., Chen, Lieping

“…Although self-reactive T-cell precursors can be eliminated upon recognition of self-antigen presented in the thymus, this central tolerance process is often…”
Get full text

B7-H2 Is a Costimulatory Ligand for CD28 in Human by Yao, Sheng, Zhu, Yuwen, Zhu, Gefeng, Augustine, Mathew, Zheng, Linghua, Goode, Diana J., Broadwater, Megan, Ruff, William, Flies, Sarah, Xu, Haiying, Flies, Dallas, Luo, Liqun, Wang, Shengdian, Chen, Lieping

“…CD28 and CTLA-4 are cell surface cosignaling molecules essential for the control of T cell activation upon the engagement of their ligands B7-1 and B7-2 from…”
Get full text