Search Results - "Flies, Andrew"

Rewilding immunology by Flies, Andrew S

“…Integrating comparative immunology can improve human, animal, and ecosystem health The common origin of all species provides a wealth of history recorded in…”
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B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells by Azuma, Takeshi, Yao, Sheng, Zhu, Gefeng, Flies, Andrew S., Flies, Sarah J., Chen, Lieping

“…B7-H1 is an immunoglobulin-like immune suppressive molecule broadly detectable on the majority of human and rodent cancers, and its functions have been…”
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Curse of the devil: molecular insights into the emergence of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii) by Patchett, Amanda L., Flies, Andrew S., Lyons, A. Bruce, Woods, Gregory M.

“…The Tasmanian devil ( Sarcophilus harrisii ) is the only mammalian species known to be affected by multiple transmissible cancers. Devil facial tumours 1 and 2…”
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A human adenovirus encoding IFN-γ can transduce Tasmanian devil facial tumour cells and upregulate MHC-I by Kayigwe, Ahab N., M. Darby, Jocelyn, Lyons, A. Bruce, L. Patchett, Amanda, Lisowski, Leszek, Liu, Guei-Sheung, S. Flies, Andrew

“…The devil facial tumour disease (DFTD) has led to a massive decline in the wild Tasmanian devil ( Sarcophilus harrisii ) population. The disease is caused by…”
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Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii) by Patchett, Amanda L., Coorens, Tim H. H., Darby, Jocelyn, Wilson, Richard, McKay, Matthew J., Kamath, Karthik S., Rubin, Alan, Wakefield, Matthew, Mcintosh, Lachlan, Mangiola, Stefano, Pye, Ruth J., Flies, Andrew S., Corcoran, Lynn M., Lyons, A. Bruce, Woods, Gregory M., Murchison, Elizabeth P., Papenfuss, Anthony T., Tovar, Cesar

“…Devil facial tumour disease (DFTD) comprises two genetically distinct transmissible cancers (DFT1 and DFT2) endangering the survival of the Tasmanian devil (…”
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Markedly Elevated Antibody Responses in Wild versus Captive Spotted Hyenas Show that Environmental and Ecological Factors Are Important Modulators of Immunity by Flies, Andrew S, Mansfield, Linda S, Grant, Chris K, Weldele, Mary L, Holekamp, Kay E

“…Evolutionary processes have shaped the vertebrate immune system over time, but proximal mechanisms control the onset, duration, and intensity of immune…”
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Generation of Devil Facial Tumour Cells Co‐Expressing MHC With CD80, CD86 or 41BBL to Enhance Tumour Immunogenicity by Ong, Chrissie E. B., Lyons, A. Bruce, Woods, Gregory M., Flies, Andrew S.

“…ABSTRACT The major histocompatibility complex (MHC) molecules play an integral role in the adaptive immune response to transmissible cancers through tumour…”
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B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets by Luo, Liqun, Zhu, Gefeng, Xu, Haiying, Yao, Sheng, Zhou, Gang, Zhu, Yuwen, Tamada, Koji, Huang, Lanqing, Flies, Andrew D, Broadwater, Megan, Ruff, William, van Deursen, Jan M A, Melero, Ignacio, Zhu, Zhou, Chen, Lieping

“…B7-H3 is a cell surface molecule in the immunoglobulin superfamily that is frequently upregulated in response to autoantigens and pathogens during host T cell…”
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NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers by Ong, Chrissie E. B., Patchett, Amanda L., Darby, Jocelyn M., Chen, Jinying, Liu, Guei-Sheung, Lyons, A. Bruce, Woods, Gregory M., Flies, Andrew S.

“…Purpose Downregulation of MHC class I (MHC-I) is a common immune evasion strategy of many cancers. Similarly, two allogeneic clonal transmissible cancers have…”
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Wildlife nidoviruses: biology, epidemiology, and disease associations of selected nidoviruses of mammals and reptiles by Flies, Andrew S, Flies, Emily J, Fountain-Jones, Nicholas M, Musgrove, Ruth E, Hamede, Rodrigo K, Philips, Annie, Perrott, Matthew R F, Dunowska, Magdalena

“…Wildlife is the source of many emerging infectious diseases. Several viruses from the order have recently emerged in wildlife, sometimes with severe…”
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Sarcoptic Mange in a Tasmanian Devil (Sarcophilus harrisii) and Bennett's Wallaby (Notamacropus rufogriseus) by Russell, Grace G., Wilkinson, Vicky, Pefanis, Stephen, Thompson, Andrew, Peck, Sarah, Dann, Alison, Pye, Ruth J., Carver, Scott, Flies, Andrew S.

“…Sarcoptes scabiei mites and skin lesions consistent with severe sarcoptic mange were identified in a Tasmanian devil (Sarcophilus harrisii) and Bennett's…”
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Cytokines: Signalling Improved Immunotherapy? by De Luca, Alana J., Lyons, A. Bruce, Flies, Andrew S.

“…Purpose of Review Immune checkpoint immunotherapies (ICI) are now approved for over 20 types of cancer and there are almost 6000 ongoing clinical trials…”
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Conversion of Mouse-Derived Hybridomas to Tasmanian Devil Recombinant IgG Antibodies by Slyp, Bailey, Darby, Jocelyn M, Flies, Andrew S

“…The hybridoma method for production of monoclonal antibodies has been a cornerstone of biomedical research for several decades. Here we convert the monoclonal…”
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Editorial: Wild Immunology-The Answers Are Out There by Flies, Andrew S, Woods, Gregory M

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Extreme Competence: Keystone Hosts of Infections by Martin, Lynn B., Addison, BriAnne, Bean, Andrew G.D., Buchanan, Katherine L., Crino, Ondi L., Eastwood, Justin R., Flies, Andrew S., Hamede, Rodrigo, Hill, Geoffrey E., Klaassen, Marcel, Koch, Rebecca E., Martens, Johanne M., Napolitano, Constanza, Narayan, Edward J., Peacock, Lee, Peel, Alison J., Peters, Anne, Raven, Nynke, Risely, Alice, Roast, Michael J., Rollins, Lee A., Ruiz-Aravena, Manuel, Selechnik, Dan, Stokes, Helena S., Ujvari, Beata, Grogan, Laura F.

“…Individual hosts differ extensively in their competence for parasites, but traditional research has discounted this variation, partly because modeling such…”
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Inducible IFN-γ Expression for MHC-I Upregulation in Devil Facial Tumor Cells by Ong, Chrissie E B, Lyons, Alan Bruce, Woods, Gregory M, Flies, Andrew S

“…The Tasmanian devil facial tumor (DFT) disease has led to an 80% reduction in the wild Tasmanian devil ( ) population since 1996. The limited genetic diversity…”
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Socioecological predictors of immune defences in wild spotted hyenas by Flies, Andrew S., Mansfield, Linda S., Flies, Emily J., Grant, Chris K., Holekamp, Kay E.

“…Summary Social rank can profoundly affect many aspects of mammalian reproduction and stress physiology, but little is known about how immune function is…”
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Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours by Ong, Chrissie E B, Cheng, Yuanyuan, Siddle, Hannah V, Lyons, A Bruce, Woods, Gregory M, Flies, Andrew S

“…MHC-I and MHC-II molecules are critical components of antigen presentation and T cell immunity to pathogens and cancer. The two monoclonal transmissible devil…”
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Understanding the evolution of immune genes in jawed vertebrates by Vinkler, Michal, Fiddaman, Steven R., Těšický, Martin, O'Connor, Emily A., Savage, Anna E., Lenz, Tobias L., Smith, Adrian L., Kaufman, Jim, Bolnick, Daniel I., Davies, Charli S., Dedić, Neira, Flies, Andrew S., Samblás, M. Mercedes Gómez, Henschen, Amberleigh E., Novák, Karel, Palomar, Gemma, Raven, Nynke, Samaké, Kalifa, Slade, Joel, Veetil, Nithya Kuttiyarthu, Voukali, Eleni, Höglund, Jacob, Richardson, David S., Westerdahl, Helena

“…Driven by co‐evolution with pathogens, host immunity continuously adapts to optimize defence against pathogens within a given environment. Recent advances in…”
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Automated Analysis of PD1 and PDL1 Expression in Lymph Nodes and the Microenvironment of Transmissible Tumors in Tasmanian Devils by Russell, Grace G., Palmieri, Chiara, Darby, Jocelyn, Morris, Gary P., Fountain-Jones, Nicholas M., Pye, Ruth J., Flies, Andrew S.

“…The wild Tasmanian devil (Sarcophilus harrisii) population has suffered a devastating decline due to two clonal transmissible cancers. The first devil facial…”
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