Search Results - "Flick, Burkhard"

Protocols for the Evaluation of Neurodevelopmental Alterations in Rabbit Models In Vitro and In Vivo by Pla, Laura, Kühne, Britta Anna, Guardia-Escote, Laia, Vázquez-Aristizabal, Paula, Loreiro, Carla, Flick, Burkhard, Gratacós, Eduard, Barenys, Marta, Illa, Miriam

“…The rabbit model is gaining importance in the field of neurodevelopmental evaluation due to its higher similarity to humans in terms of brain development and…”
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Identification of a potent endothelium-derived angiogenic factor by Jankowski, Vera, Tölle, Markus, Tran, Thi Nguyet Anh, van der Giet, Markus, Schuchardt, Mirjam, Lehmann, Kerstin, Janke, Doreen, Flick, Burkhard, Ortiz, Alberto, Ortiz, Alberto Arduan, Sanchez-Niño, Maria D, Sanchez, Niño Maria Dolores, Tepel, Martin, Zidek, Walter, Jankowski, Joachim

“…The secretion of angiogenic factors by vascular endothelial cells is one of the key mechanisms of angiogenesis. Here we report on the isolation of a new potent…”
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Pluripotent stem cell assays: Modalities and applications for predictive developmental toxicity by Piersma, Aldert H., Baker, Nancy C., Daston, George P., Flick, Burkhard, Fujiwara, Michio, Knudsen, Thomas B., Spielmann, Horst, Suzuki, Noriyuki, Tsaioun, Katya, Kojima, Hajime

“…[Display omitted] •A systematic scoping review of the literature evaluated the embryonic stem cell test (EST).•1533 publications included 18 publications…”
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Effects of the vasodilating beta-blocker nebivolol on smoking-induced endothelial dysfunction in young healthy volunteers by Schmidt, Andre

“…Objective: To assess the effect of nebivolol, a highly selective third generation β1-adrenoceptor antagonist with an endothelium-dependent vasodilatory action,…”
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Crack the egg – Improvement in the use of chicken embryos to predict developmental toxicity by Flick, Burkhard, Ramirez, Tzutzuy, Van Ravenzwaay, Bennard

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The short-term toxicity and metabolome of Benzene by Faulhammer, Frank, van Ravenzwaay, Bennard, Schnatter, A. Robert, Rooseboom, Martijn, Kamp, Hennicke, Flick, Burkhard, Giri, Varun, Sperber, Saskia, Higgins, Larry G., Penman, Michael G., Kocabas, Neslihan Aygun

“…A 14-day rat study with plasma metabolomics was conducted to evaluate the toxicity of Benzene. Wistar rats were orally administered Benzene daily at doses of…”
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The short-term toxicity and metabolome of dicyclopentadiene by van Ravenzwaay, Bennard, Kocabas, Neslihan Aygun, Faulhammer, Frank, Flick, Burkhard, Giri, Varun, Sperber, Saskia, Penman, Michael G., Higgins, Larry G., Kamp, Hennicke, Rooseboom, Martijn

“…Dicyclopentadiene (DCPD) was investigated in a 14-day oral rat toxicity study based on the OECD 407 guideline in combination with plasma metabolomics. Wistar…”
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A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil by Wilhelmi, Pia, Giri, Varun, Zickgraf, Franziska Maria, Haake, Volker, Henkes, Stefan, Driemert, Peter, Michaelis, Paul, Busch, Wibke, Scholz, Stefan, Flick, Burkhard, Barenys, Marta, Birk, Barbara, Kamp, Hennicke, Landsiedel, Robert, Funk-Weyer, Dorothee

“…A crucial component of a substance registration and regulation is the evaluation of human prenatal developmental toxicity. Current toxicological tests are…”
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Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish by Wilhelmi, Pia, Haake, Volker, Zickgraf, Franziska M., Giri, Varun, Ternes, Philipp, Driemert, Peter, Nöth, Julia, Scholz, Stefan, Barenys, Marta, Flick, Burkhard, Birk, Barbara, Kamp, Hennicke, Landsiedel, Robert, Funk-Weyer, Dorothee

“…Angiogenesis is a key process in embryonic development, a disruption of this process can lead to severe developmental defects, such as limb malformations. The…”
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Implementation of a functional endpoint to the zebrafish embryotoxicity test to evaluate craniofacial abnormalities by Barenys, Marta, Molins, Anna, Amorós-Galicia, Lola, Flick, Burkhard, Gómez-Catalán, Jesús

“…The inclusion of a read-out to detect functional consequences of craniofacial alterations in the zebrafish embryotoxicity test will allow to evaluate these…”
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A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity by Hoffmann, Sebastian, Marigliani, Bianca, Akgün-Ölmez, Sevcan Gül, Ireland, Danielle, Cruz, Rebecca, Busquet, Francois, Flick, Burkhard, Lalu, Manoj, Ghandakly, Elizabeth C, de Vries, Rob B M, Witters, Hilda, Wright, Robert A, Ölmez, Metin, Willett, Catherine, Hartung, Thomas, Stephens, Martin L, Tsaioun, Katya

“…Abstract Originally developed to inform the acute toxicity of chemicals on fish, the zebrafish embryotoxicity test (ZET) has also been proposed for assessing…”
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Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned With the Zebrafish Embryotoxicity Test by Stephens, Martin L, Akgün-Ölmez, Sevcan Gül, Hoffmann, Sebastian, de Vries, Rob, Flick, Burkhard, Hartung, Thomas, Lalu, Manoj, Maertens, Alexandra, Witters, Hilda, Wright, Robert, Tsaioun, Katya

“…Systematic review methodology is a means of addressing specific questions through structured, consistent, and transparent examinations of the relevant…”
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Uterine adenocarcinoma in the rat induced by afidopyropen. An analysis of the lesion's induction, progression and its relevance to humans by Van Cott, Andrew, Frericks, Markus, Hastings, Charles, Honarvar, Naveed, Flick, Burkhard, Fabian, Eric, van Ravenzwaay, Bennard

“…Afidopyropen is a novel insecticide that acts as a TRPV channel modulator in chordotonal organs of target insects. In two carcinogenicity studies with Fischer…”
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Investigations of putative reproductive toxicity of low-dose exposures to vinclozolin in Wistar rats by Flick, Burkhard, Schneider, Steffen, Melching-Kollmuss, Stephanie, Fussell, Karma C., Gröters, Sibylle, Buesen, Roland, Strauss, Volker, van Ravenzwaay, Bennard

“…The current investigation examines whether the fungicide vinclozolin, which has an anti-androgenic mode of action, is capable of disrupting endocrine…”
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Stem cell-derived systems in toxicology assessment by Suter-Dick, Laura, Alves, Paula M, Blaauboer, Bas J, Bremm, Klaus-Dieter, Brito, Catarina, Coecke, Sandra, Flick, Burkhard, Fowler, Paul, Hescheler, Jürgen, Ingelman-Sundberg, Magnus, Jennings, Paul, Kelm, Jens M, Manou, Irene, Mistry, Pratibha, Moretto, Angelo, Roth, Adrian, Stedman, Donald, van de Water, Bob, Beilmann, Mario

“…Industrial sectors perform toxicological assessments of their potential products to ensure human safety and to fulfill regulatory requirements. These…”
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Which endpoints of a zebrafish embryotoxicity assay improve its predictivity? by Flick, Burkhard, Jiang, Xiaoqi, Salinas, Edward, Birk, Barbara, Dammann, Martina, Otte, Jens, Mellert, Werner, Hidding, Bjoern, Landsiedel, Robert, van Ravenzwaay, Bennard

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Extended evaluation on the ES-D3 cell differentiation assay combined with the BeWo transport model, to predict relative developmental toxicity of triazole compounds by Li, Hequn, Flick, Burkhard, Rietjens, Ivonne M. C. M., Louisse, Jochem, Schneider, Steffen, van Ravenzwaay, Bennard

“…The mouse embryonic stem D3 (ES-D3) cell differentiation assay is based on the morphometric measurement of cardiomyocyte differentiation and is a promising…”
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A delayed type of three-dimensional growth of human endothelial cells under simulated weightlessness by Grimm, Daniela, Infanger, Manfred, Westphal, Kriss, Ulbrich, Claudia, Pietsch, Jessica, Kossmehl, Peter, Vadrucci, Sonia, Baatout, Sarah, Flick, Burkhard, Paul, Martin, Bauer, Johann

“…Endothelial cells (ECs) form three-dimensional (3D) aggregates without any scaffold when they are exposed to microgravity simulated by a random positioning…”
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A testing strategy for the identification of mammalian, systemic endocrine disruptors with particular focus on steroids by Kolle, Susanne N., Ramirez, Tzutzuy, Kamp, Hennicke G., Buesen, Roland, Flick, Burkhard, Strauss, Volker, van Ravenzwaay, Bennard

“…► Detection of endocrine modes of actions by the use of in vitro and in vivo assays. ► Reduction through refinement. ► Targeted and resource efficient…”
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Effects of basic fibroblast growth factor on endothelial cells under conditions of simulated microgravity by Ulbrich, Claudia, Westphal, Kriss, Baatout, Sarah, Wehland, Markus, Bauer, Johann, Flick, Burkhard, Infanger, Manfred, Kreutz, Reinhold, Vadrucci, Sonia, Egli, Marcel, Cogoli, Augusto, Derradji, Hanane, Pietsch, Jessica, Paul, Martin, Grimm, Daniela

“…Fibroblast growth factors interact with appropriate endothelial cell (EC) surface receptors and initiate intracellular signal cascades, which participate in…”
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