Search Results - "Flick, B."

Utility of in vivo metabolomics to support read-across for UVCB substances under REACH by Kamp, H., Kocabas, N. Aygun, Faulhammer, F., Synhaeve, N., Rushton, E., Flick, B., Giri, V., Sperber, S., Higgins, L. G., Penman, M. G., van Ravenzwaay, B., Rooseboom, M.

“…Structure-based grouping of chemicals for targeted testing and read-across is an efficient way to reduce resources and animal usage. For substances of unknown…”
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Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice by Viant, Mark R., Amstalden, E., Athersuch, T., Bouhifd, M., Camuzeaux, S., Crizer, D. M., Driemert, P., Ebbels, T., Ekman, D., Flick, B., Giri, V., Gómez-Romero, M., Haake, V., Herold, M., Kende, A., Lai, F., Leonards, P. E. G., Lim, P. P., Lloyd, G. R., Mosley, J., Namini, C., Rice, J. R., Romano, S., Sands, C., Smith, M. J., Sobanski, T., Southam, A. D., Swindale, L., van Ravenzwaay, B., Walk, T., Weber, R. J. M., Zickgraf, F. M., Kamp, H.

“…While grouping/read-across is widely used to fill data gaps, chemical registration dossiers are often rejected due to weak category justifications based on…”
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Whole embryo culture: an important tool in developmental toxicology today by Flick, B, Klug, S

“…The number of candidate chemicals or drugs for registration and authorization is increasing at a fast rate and only few of the existing substances have been…”
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Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57 Bl6 mice by Clark, J A, Flick, R B, Pai, L-Y, Szalayova, I, Key, S, Conley, R K, Deutch, A Y, Hutson, P H, Mezey, E

“…Considerable attention has focused on regulation of central tryptophan hydroxylase (TPH) activity and protein expression. At the time of these earlier studies,…”
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The threshold of toxicological concern for prenatal developmental toxicity in rabbits and a comparison to TTC values in rats by van Ravenzwaay, B., Dammann, M., Buesen, R., Flick, B., Schneider, S.

“…► Fifth percentile of 104 NOAELs of rabbit developmental tox studies is 2mg/kgbw. ► A TTC value for rabbit developmental toxicity of 4μg/kgbw/d was calculated…”
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In Utero Exposure to Low Doses of Bisphenol A Lead to Long-term Deleterious Effects in the Vagina by Schönfelder, G., Flick, B., Mayr, E., Talsness, C., Paul, M., Chahoud, I.

“…The origins of the “endocrine disrupter hypothesis” may be traced to reports on adolescent daughters born to women who had taken the highly potent synthetic…”
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Expression of Colony-Stimulating Factor 1 Receptor during Prostate Development and Prostate Cancer Progression by Ide, Hisamitsu, Seligson, David B., Memarzadeh, Sanaz, Xin, Li, Horvath, Steve, Dubey, Purnima, Flick, Maryann B., Kacinski, Barry M., Palotie, Aarno, Witte, Owen N.

“…Colony-stimulating factor-1 receptor (CSF-1R) is the major regulator of macrophage development and is associated with epithelial cancers of the breast and…”
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Effects of MDMA (ecstasy) and two of its metabolites on rat embryos in vitro by Barenys, M., Flick, B., Boix, N., Almeida, B., Joglar, J., Klug, S., Llobet, J.M.

“…► MDMA has concentration-dependent embryotoxic effects in cultured rat embryos. ► Two MDMA metabolites from different metabolic pathways produced embryotoxic…”
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The Activated Macrophage Colony-Stimulating Factor (CSF-1) Receptor as a Predictor of Poor Outcome in Advanced Epithelial Ovarian Carcinoma by Toy, Eugene P., Chambers, Joseph T., Kacinski, Barry M., Flick, Maryann B., Chambers, Setsuko K.

“…Objective. We have previously shown that the macrophage colony-stimulating factor receptor (CSF-1R) and its ligand, CSF-1, together predict poor prognosis in…”
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Ets-2 transdominant mutant abolishes anchorage-independent growth and macrophage colony-stimulating factor-stimulated invasion by BT20 breast carcinoma cells by SAPI, E, FLICK, M. B, RODOV, S, KACINSKI, B. M

“…Activation of the macrophage colony-stimulating factor receptor (CSF-1R) by its cognate ligand CSF-1 dramatically increases the tumorigenicity and invasive…”
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Examining Middle School Students' Knowledge and Beliefs about Earthquake and Tsunami by Lownsbery, Douglas S, Flick, Lawrence B

“…This study examined middle school students' knowledge and beliefs about earthquake and tsunami through a multidimensional perspective of conceptual change…”
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Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus by Uslaner, Jason M., Parmentier-Batteur, Sophie, Flick, Rosemarie B., Surles, Nathaniel O., Lam, June S.H., McNaughton, Caitlyn H., Jacobson, Marlene A., Hutson, Pete H.

“…In the search for strategies to treat schizophrenia, attention has focused on enhancing NMDA receptor function. In vitro experiments show that metabotropic…”
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Induction motor starting methods and issues by Larabee, J., Pellegrino, B., Flick, B.

“…Many methods can be used to start large AC induction motors. Choices such as full voltage, reduced voltage either by autotransformer or wye-delta, a soft…”
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Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections by Loughran, H. Marie, Schirripa, Kathy M., Roecker, Anthony J., Breslin, Michael J., Tong, Ling, Fillgrove, Kerry L., Kuo, Yuhsin, Bleasby, Kelly, Collier, Hannah, Altman, Michael D., Ford, Melissa C., Newman, Justin A., Drolet, Robert E., Cosden, Mali, Jinn, Sarah, Flick, Rosemarie B., Liu, Xiaomei, Minnick, Christina, Watt, Marla L., Lemaire, Wei, Burlein, Christine, Adam, Gregory C., Austin, Lauren A., Marcus, Jacob N., Smith, Sean M., Fraley, Mark E.

“…Inhibition of glucosylceramide synthase (GCS) has been proposed as a therapeutic strategy for the treatment of Parkinson’s Disease (PD), particularly in…”
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The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling by Bradley, Stefania Risso, Uslaner, Jason M., Flick, Rose B., Lee, Ariel, Groover, Kristina M., Hutson, Peter H.

“…Currently prescribed antidepressants affect the reuptake and/or metabolism of biogenic amines. Unfortunately for patients, these treatments require several…”
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A portable microsystem-based telemetric pressure and temperature measurement unit by Flick, B.B., Orglmeister, R.

“…This article shows how a fully implantable stand-by device for measuring intracorporal pressure and temperature under normal conditions can be implemented,…”
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A Model Protocol for Evaluating the Behavioral and Psychosocial Effects of BRCA1 Testing by Botkin, Jeffrey R., Croyle, Robert T., Smith, Ken R., Baty, Bonnie J., Lerman, Caryn, Goldgar, David E., Ward, John M., Flick, Bonnie J., Nash, Jean E.

“…Botkin et al discuss a model protocol for evaluating the behavioral and psychosocial effects of screening women for the BRCA1 mutation that often lead to…”
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Independent regulation of invasion and anchorage-independent growth by different autophosphorylation sites of the macrophage colony-stimulating factor 1 receptor by SAPI, E, FLICK, M. B, RODOV, S, GILMORE-HEBERT, M, KELLEY, M, ROCKWELL, S, KACINSKI, B. M

“…Invasion of tissue by macrophages and implantation into the uterine wall by placental trophoblasts are known to be regulated by the macrophage…”
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Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease by Roecker, Anthony J., Schirripa, Kathy M., Loughran, H. Marie, Tong, Ling, Liang, Tao, Fillgrove, Kerry L., Kuo, Yuhsin, Bleasby, Kelly, Collier, Hannah, Altman, Michael D., Ford, Melissa C., Drolet, Robert E., Cosden, Mali, Jinn, Sarah, Hatcher, Nathan G., Yao, Lihang, Kandebo, Monika, Vardigan, Joshua D., Flick, Rosemarie B., Liu, Xiaomei, Minnick, Christina, Price, Laura A., Watt, Marla L., Lemaire, Wei, Burlein, Christine, Adam, Gregory C., Austin, Lauren A., Marcus, Jacob N., Smith, Sean M., Fraley, Mark E.

“…Parkinson’s disease is the second most prevalent progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia…”
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Radiation Chemical Mechanisms of Single- and Double-Strand Break Formation in Irradiated SV40 DNA by Krisch, Robert E., Flick, Maryann B., Trumbore, Conrad N.

“…Using an electrophoresis assay system developed in our laboratory, we have simultaneously measured single- and double-strand DNA breaks (SSBs and DSBs) induced…”
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