Search Results - "Flibotte, Stephane"

Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan by Templeman, Nicole M., Flibotte, Stephane, Chik, Jenny H.L., Sinha, Sunita, Lim, Gareth E., Foster, Leonard J., Nislow, Corey, Johnson, James D.

“…The causal relationships between insulin levels, insulin resistance, and longevity are not fully elucidated. Genetic downregulation of insulin/insulin-like…”
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Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough by Hosseini-Farahabadi, Sara, Baradaran-Heravi, Alireza, Zimmerman, Carla, Choi, Kunho, Flibotte, Stephane, Roberge, Michel

“…Premature termination codons (PTC) cause over 10% of genetic disease cases. Some aminoglycosides that bind to the ribosome decoding center can induce PTC…”
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The million mutation project: a new approach to genetics in Caenorhabditis elegans by Thompson, Owen, Edgley, Mark, Strasbourger, Pnina, Flibotte, Stephane, Ewing, Brent, Adair, Ryan, Au, Vinci, Chaudhry, Iasha, Fernando, Lisa, Hutter, Harald, Kieffer, Armelle, Lau, Joanne, Lee, Norris, Miller, Angela, Raymant, Greta, Shen, Bin, Shendure, Jay, Taylor, Jon, Turner, Emily H, Hillier, LaDeana W, Moerman, Donald G, Waterston, Robert H

“…We have created a library of 2007 mutagenized Caenorhabditis elegans strains, each sequenced to a target depth of 15-fold coverage, to provide the research…”
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Resurrection of a Viral Internal Ribosome Entry Site from a 700 Year Old Ancient Northwest Territories Cripavirus by Wang, Xinying, Vlok, Marli, Flibotte, Stephane, Jan, Eric

“…The dicistrovirus intergenic region internal ribosome entry site (IGR IRES) uses an unprecedented, streamlined mechanism whereby the IRES adopts a…”
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Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance by Skovsø, Søs, Panzhinskiy, Evgeniy, Kolic, Jelena, Cen, Haoning Howard, Dionne, Derek A., Dai, Xiao-Qing, Sharma, Rohit B., Elghazi, Lynda, Ellis, Cara E., Faulkner, Katharine, Marcil, Stephanie A. M., Overby, Peter, Noursadeghi, Nilou, Hutchinson, Daria, Hu, Xiaoke, Li, Hong, Modi, Honey, Wildi, Jennifer S., Botezelli, J. Diego, Noh, Hye Lim, Suk, Sujin, Gablaski, Brian, Bautista, Austin, Kim, Ryekjang, Cras-Méneur, Corentin, Flibotte, Stephane, Sinha, Sunita, Luciani, Dan S., Nislow, Corey, Rideout, Elizabeth J., Cytrynbaum, Eric N., Kim, Jason K., Bernal-Mizrachi, Ernesto, Alonso, Laura C., MacDonald, Patrick E., Johnson, James D.

“…Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most other tissues, but the consequences of β-cell insulin resistance…”
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Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte by Trivedi, Purvi C., Bartlett, Jordan J., Mercer, Angella, Slade, Logan, Surette, Marc, Ballabio, Andrea, Flibotte, Stephane, Hussein, Bahira, Rodrigues, Brian, Kienesberger, Petra C., Pulinilkunnil, Thomas

“…Glucolipotoxicity following nutrient overload causes cardiomyocyte injury by inhibiting TFEB and suppressing lysosomal function. We ascertained whether in…”
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Serum MicroRNAs Reflect Injury Severity in a Large Animal Model of Thoracic Spinal Cord Injury by Tigchelaar, Seth, Streijger, Femke, Sinha, Sunita, Flibotte, Stephane, Manouchehri, Neda, So, Kitty, Shortt, Katelyn, Okon, Elena, Rizzuto, Michael A., Malenica, Ivana, Courtright-Lim, Amanda, Eisen, Andrew, Keuren-Jensen, Kendall Van, Nislow, Corey, Kwon, Brian K.

“…Therapeutic development for spinal cord injury is hindered by the difficulty in conducting clinical trials, which to date have relied solely on functional…”
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Exploring the expression patterns of palmitoylating and de-palmitoylating enzymes in the mouse brain using the curated RNA-seq database BrainPalmSeq by Wild, Angela R, Hogg, Peter W, Flibotte, Stephane, Nasseri, Glory G, Hollman, Rocio B, Abazari, Danya, Haas, Kurt, Bamji, Shernaz X

“…Protein -palmitoylation is a reversible post-translational lipid modification that plays a critical role in neuronal development and plasticity, while…”
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CellPalmSeq: A curated RNAseq database of palmitoylating and de-palmitoylating enzyme expression in human cell types and laboratory cell lines by Wild, Angela R, Hogg, Peter W, Flibotte, Stephane, Kochhar, Shruti, Hollman, Rocio B, Haas, Kurt, Bamji, Shernaz X

“…The reversible lipid modification protein S-palmitoylation can dynamically modify the localization, diffusion, function, conformation and physical interactions…”
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DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons by Noblett, Nathaniel, Wu, Zilu, Ding, Zhao Hua, Park, Seungmee, Roenspies, Tony, Flibotte, Stephane, Chisholm, Andrew D, Jin, Yishi, Colavita, Antonio

“…Neuronal morphology and circuitry established during early development must often be maintained over the entirety of animal lifespans. Compared with neuronal…”
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CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans by Au, Vinci, Li-Leger, Erica, Raymant, Greta, Flibotte, Stephane, Chen, George, Martin, Kiana, Fernando, Lisa, Doell, Claudia, Rosell, Federico I, Wang, Su, Edgley, Mark L, Rougvie, Ann E, Hutter, Harald, Moerman, Donald G

“…The Gene Knockout Consortium is tasked with obtaining null mutations in each of the more than 20,000 open reading frames (ORFs) of this organism. To date,…”
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Alterations in brain morphology by MRI in adults with neurofibromatosis 1 by Wang, Su, Mautner, Victor-Felix, Buchert, Ralph, Flibotte, Stephane, Suppa, Per, Friedman, Jan M, Heran, Manraj K S

“…Neurofibromatosis 1 (NF1) is a rare autosomal dominant disease that causes the dysregulated growth of Schwann cells. Most reported studies of brain morphology…”
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Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization by Minning, Todd A, Weatherly, D Brent, Flibotte, Stephane, Tarleton, Rick L

“…Trypanosoma cruzi is a protozoan parasite and the etiologic agent of Chagas disease, an important public health problem in Latin America. T. cruzi is diploid,…”
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Identification of essential genes in Caenorhabditis elegans through whole-genome sequencing of legacy mutant collections by Li-Leger, Erica, Feichtinger, Richard, Flibotte, Stephane, Holzkamp, Heinke, Schnabel, Ralf, Moerman, Donald G

“…Abstract It has been estimated that 15%–30% of the ∼20,000 genes in C. elegans are essential, yet many of these genes remain to be identified or characterized…”
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Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity by Mathew, Mark D, Mathew, Neal D, Miller, Angela, Simpson, Mike, Au, Vinci, Garland, Stephanie, Gestin, Marie, Edgley, Mark L, Flibotte, Stephane, Balgi, Aruna, Chiang, Jennifer, Giaever, Guri, Dean, Pamela, Tung, Audrey, Roberge, Michel, Roskelley, Calvin, Forge, Tom, Nislow, Corey, Moerman, Donald

“…The lack of new anthelmintic agents is of growing concern because it affects human health and our food supply, as both livestock and plants are affected. Two…”
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Diabetes Mellitus Severity and a Switch From Using Lipoprotein Lipase to Adipose-Derived Fatty Acid Results in a Cardiac Metabolic Signature That Embraces Cell Death by Puri, Karanjit, Lal, Nathaniel, Shang, Rui, Ghosh, Sanjoy, Flibotte, Stephane, Dyer, Roger, Hussein, Bahira, Rodrigues, Brian

“…Background Fatty acid (FA) provision to the heart is from cardiomyocyte and adipose depots, plus lipoprotein lipase action. We tested how a graded reduction in…”
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Copy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans by Maydan, Jason S, Lorch, Adam, Edgley, Mark L, Flibotte, Stephane, Moerman, Donald G

“…Copy number variation is an important component of genetic variation in higher eukaryotes. The extent of natural copy number variation in C. elegans is unknown…”
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The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing by Billmyre, Katherine Kretovich, Doebley, Anna-Lisa, Spichal, Maya, Heestand, Bree, Belicard, Tony, Sato-Carlton, Aya, Flibotte, Stephane, Simon, Matt, Gnazzo, Megan, Skop, Ahna, Moerman, Donald, Carlton, Peter Mark, Sarkies, Peter, Ahmed, Shawn

“…Germ cell immortality, or transgenerational maintenance of the germ line, could be promoted by mechanisms that could occur in either mitotic or meiotic germ…”
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Insight into the Recent Genome Duplication of the Halophilic Yeast Hortaea werneckii : Combining an Improved Genome with Gene Expression and Chromatin Structure by Sinha, Sunita, Flibotte, Stephane, Neira, Mauricio, Formby, Sean, Plemenitaš, Ana, Cimerman, Nina Gunde, Lenassi, Metka, Gostinčar, Cene, Stajich, Jason E, Nislow, Corey

“…Extremophilic organisms demonstrate the flexibility and adaptability of basic biological processes by highlighting how cell physiology adapts to environmental…”
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A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans by Gysi, Stephan, Rhiner, Christa, Flibotte, Stephane, Moerman, Donald G, Hengartner, Michael O

“…Heparan sulfate proteoglycans (HSPGs) are proteins with long covalently attached sugar side chains of the heparan sulfate (HS) type. Depending on the cellular…”
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