Search Results - "Fleuren, L."

Elucidating the Routes of Exposure for Organic Chemicals in the Earthworm, Eisenia andrei (Oligochaeta) by Jager, Tjalling, Fleuren, Roel H. L. J, Hogendoorn, Elbert A, de Korte, Gert

“…Earthworms take up organic compounds through their skin as well as from their food, but the quantitative contribution of each route is unclear. In this…”
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Solid-Phase Microextraction To Predict Bioavailability and Accumulation of Organic Micropollutants in Terrestrial Organisms after Exposure to a Field-Contaminated Soil by van der Wal, Leon, Jager, Tjalling, Fleuren, Roel H. L. J, Barendregt, Arjan, Sinnige, Theo L, van Gestel, Cornelis A. M, Hermens, Joop L. M

“…The risk posed by soil contaminants strongly depends on their bioavailability. In this study, a partition-based sampling method was applied as a tool to…”
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Bioaccumulation of Organic Chemicals in Contaminated Soils:  Evaluation of Bioassays with Earthworms by Jager, Tjalling, van der Wal, Leon, Fleuren, Roel H. L. J, Barendregt, Arjan, Hermens, Joop L. M

“…Earthworms live in close contact with the soil and can thus be considered representative for the bioavailability of chemicals at contaminated sites…”
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The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients by Slim, M. A., Lim, E. H. T., van Vught, L. A., Boer, A. M. Tuip-de, Rademaker, E., Mulier, J. L. G. Haitsma, Engel, J. J., Pickkers, P., van de Veerdonk, F. L., Vlaar, A. P. J., Derde, L. P. G., Juffermans, N. P.

“…While several effective therapies for critically ill patients with COVID-19 have been identified in large, well-conducted trials, the mechanisms underlying…”
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Head-to-head validation of six immunoassays for SARS-CoV-2 in hospitalized patients by Zonneveld, Rens, Jurriaans, Suzanne, van Gool, Tom, Hofstra, Jorrit J., Hekker, Thecla A.M., Defoer, Pien, Broekhuizen-van Haaften, Patricia E., Wentink-Bonnema, Ellen M., Boonkamp, Lynn, Teunissen, Charlotte E., Heijboer, Annemieke C., Martens, Frans, de Bree, Godelieve, van Vugt, Michele, van Houdt, Robin, Schinkel, Janke, de Jong, Menno D., van Agtmael, M., Algera, A.G., van Baarle, F., Bax, D., Beudel, M., Bogaard, H.J., Bomers, M., Bos, L., Botta, M., de Brabander, J., Brouwer, M.C., de Bruin, S., Bugiani, M., Bulle, E., Chouchane, O., Cloherty, A., Elbers, P., Fleuren, L., Geerlings, S., Geerts, B., Geijtenbeek, T., Girbes, A., Goorhuis, A., Grobusch, M.P., Hafkamp, F., Hagens, L., Hamann, J., Harris, V., Hemke, R., Hermans, S.M., Heunks, L., Hollmann, M.W., Horn, J., Hovius, J.W., Koning, R., van Mourik, N., Nellen, J., Paulus, F., Peters, E., van der Poll, T., Preckel, B., Prins, J.M., Raasveld, J., Reijnders, T., Schinkel, M., Schultz, M.J., Schuurman, A., Sigaloff, K., Smit, M., Stijnis, C.S., Stilma, W., Thoral, P., Tsonas, A., van der Valk, M., Veelo, D., Vlaar, A.P.J., de Vries, H., Wiersinga, W.J., Wouters, D., Zwinderman, A.H., van de Beek, D.

“…•Head-to-head validation of SARS-CoV-2 immunoassays remains needed.•Sensitivity of the Wantai ELISA was unparalleled by five other immunoassays.•A simple rapid…”
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Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19 by Volleman, Carolien, Ibelings, Roselique, Vlaar, Alexander P. J., van den Brom, Charissa E.

“…Endotheliopathy plays a role in the development of acute kidney and lung injury in COVID-19, probably due to inflammation, endothelial permeability, vascular…”
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Rapid Evaluation of Coronavirus Illness Severity (RECOILS) in intensive care: Development and validation of a prognostic tool for in‐hospital mortality by Plečko, Drago, Bennett, Nicolas, Mårtensson, Johan, Dam, Tariq A., Entjes, Robert, Rettig, Thijs C. D., Dongelmans, Dave A., Boelens, Age D., Rigter, Sander, Hendriks, Stefaan H. A., Jong, Remko, Kamps, Marlijn J. A., Peters, Marco, Karakus, Attila, Gommers, Diederik, Ramnarain, Dharmanand, Wils, Evert‐Jan, Achterberg, Sefanja, Nowitzky, Ralph, Tempel, Walter, Jager, Cornelis P. C., Nooteboom, Fleur G. C. A., Oostdijk, Evelien, Koetsier, Peter, Cornet, Alexander D., Reidinga, Auke C., Ruijter, Wouter, Bosman, Rob J., Frenzel, Tim, Urlings‐Strop, Louise C., Jong, Paul, Smit, Ellen G.M., Cremer, Olaf L., Mehagnoul‐Schipper, D. Jannet, Faber, Harald J., Lens, Judith, Brunnekreef, Gert B., Festen‐Spanjer, Barbara, Dormans, Tom, Bruin, Daan P., Lalisang, Robbert C. A., Vonk, Sebastiaan J. J., Haan, Martin E., Fleuren, Lucas M., Thoral, Patrick J., Elbers, Paul W. G., Bellomo, Rinaldo

“…Background The prediction of in‐hospital mortality for ICU patients with COVID‐19 is fundamental to treatment and resource allocation. The main purpose was to…”
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Pharmacokinetics of mefruside and two active metabolites in man by Fleuren, H L, Verwey-van Wissen, C P, van Rossum, J M

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Dose-dependent urinary excretion of chlorthalidone by Fleuren, H L, Verwey-van Wissen, C, van Rossum, J M

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Nonlinear relationship between plasma and red blood cell pharmacokinetics of chlorthalidone in man by Fleuren, H L, van Rossum, J M

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Absolute bioavailability of chlorthalidone in man: a cross-over study after intravenous and oral administration by Fleuren, H L, Thien, T A, Verwey-van Wissen, C P, van Rossum, J M

“…Seven normal human volunteers each received a constant-rate infusion of chlorthalidone for 2 h, and the same (commonly 50 mg) single oral dose on separate…”
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Differential potentiometric method for determining dissociation constants of very slightly water-soluble drugs applied to the sulfonamide diuretic chlorthalidone by Fleuren, H L, van Ginneken, C A, van Rossum, J M

“…A renewed application of potentiometric acid-base titrations is described, by which dissociation constants of practically water-insoluble drugs can be measured…”
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Biliary excretion of chlorthalidone in humans by Fleuren, H L, Verwey-Van Wissen, C P, Thien, T A

“…A single oral dose of the diuretic chlorthalidone (100 or 200 mg) was given to six cholecystectomized patients with T-tube drainage of the common bile duct,…”
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Linear and nonlinear kinetics of drug elimination. I. Kinetics on the basis of a single capacity-limited pathway of elimination with or without simultaneous supply-limited elimination by van Ginneken, C A, van Rossum, J M, Fleuren, H L

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Feeding behaviour of Eisenia andrei in two different field contaminated soils by Fleuren, Roel H.L.J., Jager, Tjalling, Roelofs, Willem, De Groot, Arthur C., Baerselman, Rob, Peijnenburg, Willie J.G.M.

“…The compost worm Eisenia andrei is a commonly used test species in soil. Because the earthworm's behaviour in soil is important for the uptake of contaminants,…”
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Feeding activity of the earthworm Eisenia andrei in artificial soil by Jager, Tjalling, Fleuren, Roel H.L.J., Roelofs, Willem, de Groot, Arthur C.

“…Quantitative information on the feeding activity of earthworms is scarce but this information is valuable in many eco(toxico)logical studies. In this study,…”
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Determination of chlorthalidone in plasma, urine and red blood cells by gas chromatography with nitrogen detection by Fleuren, H L, Van Rossum, J M

“…A sensitive and selective gas chromatographic method is described for determining the diuretic and antihypertensive drug chlorthalidone in plasma, urine and…”
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Rapid determination of diazoxide in plasma and urine of man by means of high-performance liquid chromatography by Vree, T B, Lenselink, B, Huysmans, F T, Fleuren, H L, Thien, T A

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Quantitative gas chromatographic determination of two oxidized metabolites of the diuretic mefruside in human urine, plasma and red blood cells by Fleuren, H L, Verwey-Van Wissen, C P, Van Rossum, J M

“…A gas chromatographic method is reported for the quantitative analysis of two metabolites of mefruside, viz., 5-oxo-mefruside (mefruside lactone) and its…”
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Quantitative gas chromatographic determination of mefruside in body fluids by extractive methylation and nitrogen detection by Fleuren, H L, Verwey-van Wissen, C P, van Rossum, J M

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