Search Results - "Fleuren, Emmy"

The kinome 'at large' in cancer by Fleuren, Emmy D. G., Zhang, Luxi, Wu, Jianmin, Daly, Roger J.

“…Key Points Application of high-throughput omics technologies has provided important and complementary insights into dysregulation of protein kinases in human…”
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Biological and clinical implications of FGFR aberrations in paediatric and young adult cancers by Brown, Lauren M., Ekert, Paul G., Fleuren, Emmy D. G.

“…Rare but recurrent mutations in the fibroblast growth factor receptor (FGFR) pathways, most commonly in one of the four FGFR receptor tyrosine kinase genes,…”
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Directing the use of DDR kinase inhibitors in cancer treatment by Brandsma, Inger, Fleuren, Emmy D G, Williamson, Chris T, Lord, Christopher J

“…Defects in the DNA damage response (DDR) drive the development of cancer by fostering DNA mutation but also provide cancer-specific vulnerabilities that can be…”
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Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer by Wong, Marie, Mayoh, Chelsea, Lau, Loretta M. S., Khuong-Quang, Dong-Anh, Pinese, Mark, Kumar, Amit, Barahona, Paulette, Wilkie, Emilie E., Sullivan, Patricia, Bowen-James, Rachel, Syed, Mustafa, Martincorena, Iñigo, Abascal, Federico, Sherstyuk, Alexandra, Bolanos, Noemi A., Baber, Jonathan, Priestley, Peter, Dolman, M. Emmy M., Fleuren, Emmy D. G., Gauthier, Marie-Emilie, Mould, Emily V. A., Gayevskiy, Velimir, Gifford, Andrew J., Grebert-Wade, Dylan, Strong, Patrick A., Manouvrier, Elodie, Warby, Meera, Thomas, David M., Kirk, Judy, Tucker, Katherine, O’Brien, Tracey, Alvaro, Frank, McCowage, Geoffry B., Dalla-Pozza, Luciano, Gottardo, Nicholas G., Tapp, Heather, Wood, Paul, Khaw, Seong-Lin, Hansford, Jordan R., Moore, Andrew S., Norris, Murray D., Trahair, Toby N., Lock, Richard B., Tyrrell, Vanessa, Haber, Michelle, Marshall, Glenn M., Ziegler, David S., Ekert, Paul G., Cowley, Mark J.

“…The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and…”
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ATR Is a Therapeutic Target in Synovial Sarcoma by Jones, Samuel E, Fleuren, Emmy D G, Frankum, Jessica, Konde, Asha, Williamson, Chris T, Krastev, Dragomir B, Pemberton, Helen N, Campbell, James, Gulati, Aditi, Elliott, Richard, Menon, Malini, Selfe, Joanna L, Brough, Rachel, Pettitt, Stephen J, Niedzwiedz, Wojciech, van der Graaf, Winette T A, Shipley, Janet, Ashworth, Alan, Lord, Christopher J

“…Synovial sarcoma (SS) is an aggressive soft-tissue malignancy characterized by expression of SS18-SSX fusions, where treatment options are limited. To identify…”
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Targeted Therapy-based Combination Treatment in Rhabdomyosarcoma by van Erp, Anke E M, Versleijen-Jonkers, Yvonne M H, van der Graaf, Winette T A, Fleuren, Emmy D G

“…Targeted therapies have revolutionized cancer treatment; however, progress lags behind in alveolar (ARMS) and embryonal rhabdomyosarcoma (ERMS), a soft-tissue…”
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Precision medicine and phosphoproteomics for the identification of novel targeted therapeutic avenues in sarcomas by Fordham, Ashleigh M., Ekert, Paul G., Fleuren, Emmy D.G.

“…Rapid advances in genomic technologies have enabled in-depth interrogation of cancer genomes, revealing novel and unexpected therapeutic targets in many cancer…”
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Expression and clinical relevance of MET and ALK in Ewing sarcomas by Fleuren, Emmy D.G., Roeffen, Melissa H.S., Leenders, William P., Flucke, Uta E., Vlenterie, Myrella, Schreuder, Hendrik W., Boerman, Otto C., Graaf, Winette T.A., Versleijen‐Jonkers, Yvonne M.H.

“…Because novel therapeutic options are limited in Ewing sarcomas (ES), we investigated the expression, genetic aberrations and clinical relevance of MET and…”
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Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes by Fleuren, Emmy D G, Vlenterie, Myrella, van der Graaf, Winette T A, Hillebrandt-Roeffen, Melissa H S, Blackburn, James, Ma, Xiuquan, Chan, Howard, Magias, Mandy C, van Erp, Anke, van Houdt, Laurens, Cebeci, Sabri A S, van de Ven, Amy, Flucke, Uta E, Heyer, Erin E, Thomas, David M, Lord, Christopher J, Marini, Kieren D, Vaghjiani, Vijesh, Mercer, Tim R, Cain, Jason E, Wu, Jianmin, Versleijen-Jonkers, Yvonne M H, Daly, Roger J

“…Despite intensive multimodal treatment of sarcomas, a heterogeneous group of malignant tumors arising from connective tissue, survival remains poor…”
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Systemic Treatment for Adults with Synovial Sarcoma by Desar, Ingrid M. E., Fleuren, Emmy D. G., van der Graaf, Winette T. A.

“…Opinion Statement Synovial sarcoma (SS) is a rare, yet highly malignant, type of soft tissue sarcoma (STS), for which survival has not improved significantly…”
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Olaparib and temozolomide in desmoplastic small round cell tumors: a promising combination in vitro and in vivo by van Erp, Anke E. M., van Houdt, Laurens, Hillebrandt-Roeffen, Melissa H. S., van Bree, Niek F. H. N., Flucke, Uta E., Mentzel, Thomas, Shipley, Janet, Desar, Ingrid M. E., Fleuren, Emmy D. G., Versleijen-Jonkers, Yvonne M. H., van der Graaf, Winette T. A.

“…Purpose Desmoplastic small round cell tumors (DSRCTs) are highly malignant and very rare soft tissue sarcomas with a high unmet need for new therapeutic…”
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Precision-guided treatment in high-risk pediatric cancers by Lau, Loretta M. S., Khuong-Quang, Dong-Anh, Mayoh, Chelsea, Wong, Marie, Barahona, Paulette, Ajuyah, Pamela, Senapati, Akanksha, Nagabushan, Sumanth, Sherstyuk, Alexandra, Altekoester, Ann-Kristin, Fuentes-Bolanos, Noemi A., Yeung, Veronica, Sullivan, Ashleigh, Omer, Natacha, Diamond, Yonatan, Jessop, Sophie, Battaglia, Lauren, Zhukova, Nataliya, Cui, Louise, Lin, Angela, Gifford, Andrew J., Fleuren, Emmy D. G., Dalla-Pozza, Luciano, Moore, Andrew S., Khaw, Seong-Lin, Eisenstat, David D., Gottardo, Nicholas G., Wood, Paul J., Tapp, Heather, Alvaro, Frank, McCowage, Geoffrey, Nicholls, Wayne, Hansford, Jordan R., Manoharan, Neevika, Kotecha, Rishi S., Mateos, Marion K., Lock, Richard B., Tyrrell, Vanessa, Haber, Michelle, Trahair, Toby N., Cowley, Mark J., Ekert, Paul G., Marshall, Glenn M., Ziegler, David S.

“…Recent research showed that precision medicine can identify new treatment strategies for patients with childhood cancers. However, it is unclear which patients…”
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Recent advances on anti-angiogenic multi-receptor tyrosine kinase inhibitors in osteosarcoma and Ewing sarcoma by Fleuren, Emmy D G, Vlenterie, Myrella, van der Graaf, Winette T A

“…Osteosarcoma (OS) and Ewing sarcoma (ES) are the two most common types of primary bone cancer that predominantly affect the young. Despite aggressive…”
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Temsirolimus combined with cisplatin or bevacizumab is active in osteosarcoma models by Fleuren, Emmy D.G., Versleijen‐Jonkers, Yvonne M.H., Roeffen, Melissa H.S., Franssen, Gerben M., Flucke, Uta E., Houghton, Peter J., Oyen, Wim J.G., Boerman, Otto C., Graaf, Winette T.A.

“…Mammalian target of rapamycin (mTOR) is a new promising oncological target. However, most clinical studies reported only modest antitumor activity during…”
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Theranostic applications of antibodies in oncology by Fleuren, Emmy D.G., Versleijen-Jonkers, Yvonne M.H., Heskamp, Sandra, van Herpen, Carla M.L., Oyen, Wim J.G., van der Graaf, Winette T.A., Boerman, Otto C.

“…Targeted therapies, including antibodies, are becoming increasingly important in cancer therapy. Important limitations, however, are that not every patient…”
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Chimeric Antigen Receptor T cell Therapy and the Immunosuppressive Tumor Microenvironment in Pediatric Sarcoma by Terry, Rachael L., Meyran, Deborah, Fleuren, Emmy D. G., Mayoh, Chelsea, Zhu, Joe, Omer, Natacha, Ziegler, David S., Haber, Michelle, Darcy, Phillip K., Trapani, Joseph A., Neeson, Paul J., Ekert, Paul G.

“…Sarcomas are a diverse group of bone and soft tissue tumors that account for over 10% of childhood cancers. Outcomes are particularly poor for children with…”
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The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis by Murray, Jayne E., Valli, Emanuele, Milazzo, Giorgio, Mayoh, Chelsea, Gifford, Andrew J., Fletcher, Jamie I., Xue, Chengyuan, Jayatilleke, Nisitha, Salehzadeh, Firoozeh, Gamble, Laura D., Rouaen, Jourdin R. C., Carter, Daniel R., Forgham, Helen, Sekyere, Eric O., Keating, Joanna, Eden, Georgina, Allan, Sophie, Alfred, Stephanie, Kusuma, Frances K., Clark, Ashleigh, Webber, Hannah, Russell, Amanda J., de Weck, Antoine, Kile, Benjamin T., Santulli, Martina, De Rosa, Piergiuseppe, Fleuren, Emmy D. G., Gao, Weiman, Wilkinson-White, Lorna, Low, Jason K. K., Mackay, Joel P., Marshall, Glenn M., Hilton, Douglas J., Giorgi, Federico M., Koster, Jan, Perini, Giovanni, Haber, Michelle, Norris, Murray D.

“…MYCN oncogene amplification is frequently observed in aggressive childhood neuroblastoma. Using an unbiased large-scale mutagenesis screen in…”
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Targeting the FAK-Src Complex in Desmoplastic Small Round Cell Tumors, Ewing Sarcoma, and Rhabdomyosarcoma by van Erp, Anke E. M., Hillebrandt-Roeffen, Melissa H. S., van Bree, Niek F. H. N., Plüm, Tim A., Flucke, Uta. E., Desar, Ingrid M. E., Fleuren, Emmy D. G., van der Graaf, Winette T. A., Versleijen-Jonkers, Yvonne M. H.

“…Desmoplastic small round cell tumors (DSRCTs), Ewing sarcoma (ES), and alveolar and embryonal rhabdomyosarcoma (ARMS and ERMS) are malignant sarcomas typically…”
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Targeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients by Vlenterie, Myrella, Hillebrandt-Roeffen, Melissa H. S., Schaars, Esther W. M., Flucke, Uta E., Fleuren, Emmy D. G., Navis, Anna C., Leenders, William P. J., Versleijen-Jonkers, Yvonne M. H., van der Graaf, Winette T. A.

“…Background In synovial sarcomas alterations in the cyclin D1-CDK4/6-Rb axis have been described. Also, β-catenin, a cyclin D1 regulator, is often…”
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The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma by Fleuren, Emmy D G, Hillebrandt-Roeffen, Melissa H S, Flucke, Uta E, Te Loo, D Maroeska W M, Boerman, Otto C, van der Graaf, Winette T A, Versleijen-Jonkers, Yvonne M H

“…New targets for Ewing sarcoma (ES) patients are urgently needed. Therefore, we investigated the expression and genetic aberrations of the oncogenic receptor…”
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