Search Results - "Fletcher, Patrick A."

Cell Type- and Sex-Dependent Transcriptome Profiles of Rat Anterior Pituitary Cells by Fletcher, Patrick A, Smiljanic, Kosara, Maso Prévide, Rafael, Iben, James R, Li, Tianwei, Rokic, Milos B, Sherman, Arthur, Coon, Steven L, Stojilkovic, Stanko S

“…Understanding the physiology and pathology of an organ composed of a variety of cell populations depends critically on genome-wide information on each cell…”
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Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells by Marinelli, Isabella, Fletcher, Patrick A, Sherman, Arthur S, Satin, Leslie S, Bertram, Richard

“…Insulin is secreted in a pulsatile pattern, with important physiological ramifications. In pancreatic β-cells, which are the cells that synthesize insulin,…”
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Lamina Propria and Olfactory Bulb Ensheathing Cells Exhibit Differential Integration and Migration and Promote Differential Axon Sprouting in the Lesioned Spinal Cord by Richter, Miranda W, Fletcher, Patrick A, Liu, Jie, Tetzlaff, Wolfram, Roskams, A. Jane

“…Olfactory bulb-derived (central) ensheathing cell (OB OEC) transplants have shown significant promise in rat models of spinal cord injury, prompting the use of…”
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Interpreting frequency responses to dose-conserved pulsatile input signals in simple cell signaling motifs by Fletcher, Patrick A, Clément, Frédérique, Vidal, Alexandre, Tabak, Joel, Bertram, Richard

“…Many hormones are released in pulsatile patterns. This pattern can be modified, for instance by changing pulse frequency, to encode relevant physiological…”
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Calcium-Prolactin Secretion Coupling in Rat Pituitary Lactotrophs Is Controlled by PI4-Kinase Alpha by Kučka, Marek, Gonzalez-Iglesias, Arturo E, Tomić, Melanija, Prévide, Rafael M, Smiljanic, Kosara, Sokanovic, Srdjan J, Fletcher, Patrick A, Sherman, Arthur, Balla, Tamas, Stojilkovic, Stanko S

“…The role of calcium, but not of other intracellular signaling molecules, in the release of pituitary hormones by exocytosis is well established. Here, we…”
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An Integrated Model of Electrical Spiking, Bursting, and Calcium Oscillations in GnRH Neurons by Fletcher, Patrick A., Li, Yue-Xian

“…The plasma membrane electrical activities of neurons that secrete gonadotropin-releasing hormone (GnRH) have been studied extensively. A couple of mathematical…”
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Common and diverse elements of ion channels and receptors underlying electrical activity in endocrine pituitary cells by Fletcher, Patrick A., Sherman, Arthur, Stojilkovic, Stanko S.

“…The pituitary gland contains six types of endocrine cells defined by hormones they secrete: corticotrophs, melanotrophs, gonadotrophs, thyrotrophs,…”
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KATP channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production by Corradi, Jeremías, Thompson, Benjamin, Fletcher, Patrick A., Bertram, Richard, Sherman, Arthur S., Satin, Leslie S.

“…Pancreatic beta cells secrete insulin in response to plasma glucose. The ATP‐sensitive potassium channel (KATP) links glucose metabolism to islet electrical…”
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K ATP channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production by Corradi, Jeremías, Thompson, Benjamin, Fletcher, Patrick A, Bertram, Richard, Sherman, Arthur S, Satin, Leslie S

“…Pancreatic beta cells secrete insulin in response to plasma glucose. The ATP-sensitive potassium channel (K ) links glucose metabolism to islet electrical…”
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Oscillations in K(ATP) conductance drive slow calcium oscillations in pancreatic β-cells by Marinelli, Isabella, Thompson, Benjamin M., Parekh, Vishal S., Fletcher, Patrick A., Gerardo-Giorda, Luca, Sherman, Arthur S., Satin, Leslie S., Bertram, Richard

“…ATP-sensitive K+ (K(ATP)) channels were first reported in the β-cells of pancreatic islets in 1984, and it was soon established that they are the primary means…”
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The astroglial and stem cell functions of adult rat folliculostellate cells by Fletcher, Patrick A., Smiljanic, Kosara, Prévide, Rafael M., Constantin, Stephanie, Sherman, Arthur S., Coon, Steven L., Stojilkovic, Stanko S.

“…The mammalian pituitary gland is a complex organ consisting of hormone‐producing cells, anterior lobe folliculostellate cells (FSCs), posterior lobe…”
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Deconstructing the integrated oscillator model for pancreatic β-cells by Bertram, Richard, Marinelli, Isabella, Fletcher, Patrick A., Satin, Leslie S., Sherman, Arthur S.

“…Electrical bursting oscillations in the β-cells of pancreatic islets have been a focus of investigation for more than fifty years. This has been aided by…”
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Modeling the diversity of spontaneous and agonist-induced electrical activity in anterior pituitary corticotrophs by Fletcher, Patrick A, Zemkova, Hana, Stojilkovic, Stanko S, Sherman, Arthur

“…Pituitary corticotrophs fire action potentials spontaneously and in response to stimulation with corticotropin-releasing hormone (CRH) and arginine vasopressin…”
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Ca 2+ release or Ca 2+ entry, that is the question: what governs Ca 2+ oscillations in pancreatic β cells? by Fletcher, Patrick A, Thompson, Ben, Liu, Chanté, Bertram, Richard, Satin, Leslie S, Sherman, Arthur S

“…The standard model for Ca oscillations in insulin-secreting pancreatic β cells centers on Ca entry through voltage-activated Ca channels. These work in…”
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Distribution and calcium signaling function of somatostatin receptor subtypes in rat pituitary by Sivcev, Sonja, Constantin, Stephanie, Smiljanic, Kosara, Sokanovic, Srdjan J., Fletcher, Patrick A., Sherman, Arthur S., Zemkova, Hana, Stojilkovic, Stanko S.

“…•The pituitary gland expresses the somatostatin receptor genes Sstr1, Sstr2, Sstr3, and Sstr5.•Gonadotrophs and lactotrophs express Sstr3; thyrotrophs Sstr1…”
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Divergent expression patterns of pituitary gonadotropin subunit and GnRH receptor genes to continuous GnRH in vitro and in vivo by Janjic, Marija M., Prévide, Rafael M., Fletcher, Patrick A., Sherman, Arthur, Smiljanic, Kosara, Abebe, Daniel, Bjelobaba, Ivana, Stojilkovic, Stanko S.

“…Continuous, as opposed to pulsatile, delivery of hypothalamic gonadotropin-releasing hormone (GnRH) leads to a marked decrease in secretion of pituitary…”
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Cell-Type-Specific Expression Pattern of Proton-Sensing Receptors and Channels in Pituitary Gland by Wang, Kai, Kretschmannova, Karla, Prévide, Rafael M., Smiljanic, Kosara, Chen, Qing, Fletcher, Patrick A., Sherman, Arthur, Stojilkovic, Stanko S.

“…In mammalian cells, extracellular protons act as orthosteric and allosteric ligands for multiple receptors and channels. The aim of this study is to identify…”
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Pituitary adenomas evade apoptosis via noxa deregulation in Cushing’s disease by Asuzu, David T., Alvarez, Reinier, Fletcher, Patrick A., Mandal, Debjani, Johnson, Kory, Wu, Weiwei, Elkahloun, Abdel, Clavijo, Paul, Allen, Clint, Maric, Dragan, Ray-Chaudhury, Abhik, Rajan, Sharika, Abdullaev, Zied, Nwokoye, Diana, Aldape, Kenneth, Nieman, Lynnette K., Stratakis, Constantine, Stojilkovic, Stanko S., Chittiboina, Prashant

“…Sporadic pituitary adenomas occur in over 10% of the population. Hormone-secreting adenomas, including those causing Cushing’s disease (CD), cause severe…”
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Direct Stimulatory Effects of Oxytocin in Female Rat Gonadotrophs and Somatotrophs In Vitro: Comparison With Lactotrophs by Gonzalez-Iglesias, Arturo E, Fletcher, Patrick A, Arias-Cristancho, José A, Cristancho-Gordo, Ruth, Helena, Cleyde V, Bertram, Richard, Tabak, Joël

“…The peptide oxytocin (OT) is secreted by hypothalamic neurons and exerts numerous actions related to reproduction. OT stimulation of prolactin secretion in…”
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Pituitary corticotroph identity and receptor-mediated signaling: A transcriptomics perspective by Stojilkovic, Stanko S., Prévide, Rafael M., Sherman, Arthur S., Fletcher, Patrick A.

“…Recent single-cell RNA sequencing has offered an unprecedented view of pituitary cell transcriptomic profiles. In this review, these new data are briefly…”
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