Effects of high- and low-risk diets on gut microflora-associated biomarkers of colon cancer in human flora-associated rats

Formulated diets associated with a high risk (HR) or low risk (LR) for colon cancer were used to assess the effect of diet on putative metabolic biomarkers in human flora-associated rats: The HR diet was high in fat and sucrose and low in calcium and fiber; the LR diet was low in fat and high in sta...

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Published in:	Nutrition and cancer Vol. 27; no. 3; pp. 250 - 255
Main Authors:	Hambly, R.J, Rumney, C.J, Fletcher, J.M.E, Rijken, P.J, Rowland, I.R
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA Taylor & Francis Group 1997 Taylor& Francis
Subjects:	ANIMAL MODELS Animals beta-Glucosidase - metabolism Biological and medical sciences BIOLOGICAL INDICATORS Biomarkers, Tumor BODY WEIGHT Calcium - administration & dosage Carcinogenesis, carcinogens and anticarcinogens CARCINOGENOS CARCINOGENS Colonic Neoplasms - enzymology Colonic Neoplasms - microbiology CORPS GRAS DIET DIETA Dietary Fats - administration & dosage Dietary Fats - adverse effects Dietary Fiber - administration & dosage Dietary Sucrose - administration & dosage Dietary Sucrose - adverse effects EXPERIMENTACION EXPERIMENTATION FATS Female FLORA MICROBIANA FLORE MICROBIENNE Foods and miscellaneous GENOTOXICIDAD GENOTOXICITE GENOTOXICITY Glucuronidase - metabolism GRASAS Humans INDICATOR ORGANISMS INGESTION DE NUTRIENTES INGESTION DE SUBSTANCES NUTRITIVES INTESTIN INTESTINES Intestines - enzymology Intestines - microbiology INTESTINOS Male Medical sciences MICROBIAL FLORA MODELE ANIMAL MODELOS ANIMALES NEOPLASMAS NEOPLASME NEOPLASMS NUTRIENT CONTENT NUTRIENT INTAKE NUTRITIVE VALUE ORGANISME INDICATEUR ORGANISMOS INDICADORES PESO CORPORAL POIDS CORPOREL QUINOLEINE QUINOLINAS QUINOLINES Quinolines - metabolism Rats Rats, Inbred F344 REGIME ALIMENTAIRE RIESGO RISK RISK FACTORS RISQUE SUBSTANCE CANCERIGENE Tumors VALEUR NUTRITIVE VALOR NUTRITIVO Human High risk Rectal disease Carcinoma Rat Rodentia Gut Biological marker Tumoral marker Malignant tumor Associated flora Colonic disease Vertebrata Mammalia Diet Animal Rectum Digestive diseases Intestinal disease Colon Comparative study
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Summary:	Formulated diets associated with a high risk (HR) or low risk (LR) for colon cancer were used to assess the effect of diet on putative metabolic biomarkers in human flora-associated rats: The HR diet was high in fat and sucrose and low in calcium and fiber; the LR diet was low in fat and high in starch, calcium, and fiber. The nutrient-to-energy ratio and energy intake were the same for both diets. Body and liver weights were significantly higher in animals fed the HR diet, possibly due to greater energy availability from fat. Cecal weights were significantly higher in animals fed the LR diet, presumably due to a bulking effect of the fiber and increased bacterial biomass. The HR diet significantly altered cecal bacterial enzyme activity: beta-glucuronidase activity increased 2.5-fold, and beta-glucosidase activity was halved. Ammonia production and the bacterial metabolism of 2-amino-3-methyl-7H-imidazo[4,5-f] quinoline (IQ) to 7-hydroxy-IQ (7OHIQ) were significantly higher in animals fed the HR diet. The HR diet, which contained factors common to diets consumed throughout the Western world, increased beta-glucuronidase activity, elevated cecal ammonia concentrations, and enhanced the genotoxic risk from 7OHIQ formation, three putative metabolic biomarkers of colorectal cancer. The significance of the reduction in beta-glucosidase is unclear
Bibliography:	S20 S30 T10 1997074241 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0163-5581 1532-7914
DOI:	10.1080/01635589709514534