Search Results - "Fletcher, Claire E"

The Role of Splicing Regulators in the Emergence of Treatment-induced Neuroendocrine Prostate Cancer: The Next Generation of Drug Targets? by Fletcher, Claire E.

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Androgen-regulated processing of the oncomir MiR-27a, which targets Prohibitin in prostate cancer by FLETCHER, Claire E, DART, D. Alwyn, SITA-LUMSDEN, Ailsa, CHENG, Helen, RENNIE, Paul S, BEAN, Charlotte L

“…MicroRNAs (miRs) play an important role in the development of many complex human diseases and may have tumour suppressor or oncogenic (oncomir) properties…”
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Androgen receptor modulatory miR-1271-5p can promote hormone sensitive prostate cancer cell growth by Kalofonou, Foteini, Leach, Damien A, Powell, Sue M, Waxman, Jonathan, Fletcher, Claire E, Bevan, Charlotte L

“…In most patients with advanced prostate cancer treated with hormonal therapy, androgen independence eventually emerges, leading to death. Androgen receptor…”
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Coordinated AR and microRNA regulation in prostate cancer by Eringyte, Ieva, Zamarbide Losada, Joanna N., Powell, Sue M., Bevan, Charlotte L., Fletcher, Claire E.

“…The androgen receptor (AR) remains a key driver of prostate cancer (PCa) progression, even in the advanced castrate-resistant stage, where testicular androgens…”
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Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer by Fletcher, Claire E., Sulpice, Eric, Combe, Stephanie, Shibakawa, Akifumi, Leach, Damien A., Hamilton, Mark P., Chrysostomou, Stelios L., Sharp, Adam, Welti, Jon, Yuan, Wei, Dart, Dafydd. A., Knight, Eleanor, Ning, Jian, Francis, Jeffrey C., Kounatidou, Evangelia E., Gaughan, Luke, Swain, Amanda, Lupold, Shawn E., de Bono, Johann S., McGuire, Sean E., Gidrol, Xavier, Bevan, Charlotte L.

“…Androgen receptor (AR) signalling is a key prostate cancer (PC) driver, even in advanced ‘castrate-resistant’ disease (CRPC). To systematically identify…”
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A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis by Fletcher, Claire E, Godfrey, Jack D, Shibakawa, Akifumi, Bushell, Martin, Bevan, Charlotte L

“…Regulation of microRNA (miR) biogenesis is complex and stringently controlled. Here, we identify the kinase GSK3β as an important modulator of miR biogenesis…”
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Interplay between steroid signalling and microRNAs: implications for hormone-dependent cancers by Fletcher, Claire E, Dart, D Alwyn, Bevan, Charlotte L

“…Hormones are key drivers of cancer development. To date, interest has largely been focussed on the classical model of hormonal gene regulation, but there is…”
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Circulating peripheral blood mononuclear cells exhibit altered miRNA expression patterns in pancreatic cancer by Frampton, Adam E, Fletcher, Claire E, Gall, Tamara Mh, Castellano, Leandro, Bevan, Charlotte L, Stebbing, Justin, Krell, Jonathan

“…Evaluation of: Wang WS, Liu LX, Li GP et al. Combined serum CA19-9 and miR-27a-3p in peripheral blood mononuclear cells to diagnose pancreatic cancer. Cancer…”
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Circulating nucleic acids as biomarkers of prostate cancer by Sita-Lumsden, Ailsa, Fletcher, Claire E, Dart, D Alwyn, Brooke, Greg N, Waxman, Jonathan, Bevan, Charlotte L

“…Prostate cancer, the most common cancer of western men, requires new biomarkers, especially given that the benefits of PSA testing remain uncertain. Nucleic…”
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Interactions of microrna27a and prohibitin in the androgen signalling pathway by Fletcher, Claire E

“…Prohibitin (PHB) is a highly conserved, multi-functional protein that acts as a tumour suppressor and androgen receptor (AR) corepressor. We found that…”
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