Search Results - "Fletcher, A J"

Heterogeneity of kinase inhibitor resistance mechanisms in GIST by Liegl, B, Kepten, I, Le, C, Zhu, M, Demetri, GD, Heinrich, MC, Fletcher, CDM, Corless, CL, Fletcher, JA

“…Most GIST patients develop clinical resistance to KIT/PDGFRA tyrosine kinase inhibitors (TKI). However, it is unclear whether clinical resistance results from…”
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KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase AKT is a crucial survival pathway by BAUER, S, DUENSING, A, DEMETRI, G. D, FLETCHER, J. A

“…Most gastrointestinal stromal tumor (GIST) patients respond to KIT inhibition with imatinib, yet will eventually exhibit resistance. Imatinib-resistance…”
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Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors by Obata, Y, Horikawa, K, Takahashi, T, Akieda, Y, Tsujimoto, M, Fletcher, J A, Esumi, H, Nishida, T, Abe, R

“…Gastrointestinal stromal tumors (GISTs) are caused by gain-of-function mutations in the Kit receptor tyrosine kinase. Most primary GIST patients respond to the…”
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Multipoint targeting of the PI3K/mTOR pathway in mesothelioma by Zhou, S, Liu, L, Li, H, Eilers, G, Kuang, Y, Shi, S, Yan, Z, Li, X, Corson, J M, Meng, F, Zhou, H, Sheng, Q, Fletcher, J A, Ou, W-B

“…Background: Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident in the dismal overall survival for patients with those of…”
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BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells by French, C A, Ramirez, C L, Kolmakova, J, Hickman, T T, Cameron, M J, Thyne, M E, Kutok, J L, Toretsky, J A, Tadavarthy, A K, Kees, U R, Fletcher, J A, Aster, J C

“…An unusual group of carcinomas, here termed nuclear protein in testis (NUT) midline carcinomas (NMC), are characterized by translocations that involve NUT , a…”
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Hydrogen Adsorption on Functionalized Nanoporous Activated Carbons by Zhao, X. B, Xiao, B, Fletcher, A. J, Thomas, K. M

“…There is considerable interest in hydrogen adsorption on carbon nanotubes and porous carbons as a method of storage for transport and related energy…”
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AXL regulates mesothelioma proliferation and invasiveness by Ou, W-B, Corson, J M, Flynn, D L, Lu, W-P, Wise, S C, Bueno, R, Sugarbaker, D J, Fletcher, J A

“…Mesothelioma is an asbestos-associated and notoriously chemotherapy-resistant neoplasm. Activation of the receptor tyrosine kinases (RTKs), epidermal growth…”
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Echocardiographic RV-E/e′ for predicting right atrial pressure: a review by Fletcher, A J, Robinson, S, Rana, B S

“…Right atrial pressure (RAP) is a key cardiac parameter of diagnostic and prognostic significance, yet current two-dimensional echocardiographic methods are…”
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Echocardiographic RV-E/e′ for predicting right atrial pressure: a review by Fletcher, A. J., Robinson, S., Rana, B. S.

“…Abstract Right atrial pressure (RAP) is a key cardiac parameter of diagnostic and prognostic significance, yet current two-dimensional echocardiographic…”
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Protein kinase C-θ regulates KIT expression and proliferation in gastrointestinal stromal tumors by Ou, W-b, Zhu, M-j, Demetri, G D, Fletcher, C D M, Fletcher, J A

“…Oncogenic KIT or PDGFRA receptor tyrosine kinase mutations are compelling therapeutic targets in gastrointestinal stromal tumors (GISTs), and the KIT/PDGFRA…”
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KIT activation is a ubiquitous feature of gastrointestinal stromal tumors by RUBIN, Brian P, SINGER, Samuel, DEMETRI, George D, FLETCHER, Christopher D. M, FLETCHER, Jonathan A, TSAO, Connie, DUENSING, Anette, LUX, Marcia L, RUIZ, Robert, HIBBARD, Michele K, CHEN, Chang-Jie, SHENG XIAO, TUVESON, David A

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, and they are generally resistant to chemotherapy…”
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KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance by ZHU, M.-J, OU, W.-B, FLETCHER, C. D. M, COHEN, P. S, DEMETRI, G. D, FLETCHER, J. A

“…Most gastrointestinal stromal tumors (GISTs) express oncogenic and constitutively active forms of the KIT or platelet-derived growth factor receptor alpha…”
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Adsorption of Pb(II) ions from contaminated water by 1,2,3,4-butanetetracarboxylic acid-modified microcrystalline cellulose: Isotherms, kinetics, and thermodynamic studies by Hashem, A., Fletcher, A.J., Younis, H., Mauof, H., Abou-Okeil, A.

“…Microcrystalline cellulose (MCC) has been utilized as an adsorbent material for the removal of Pb(II) ions from aqueous solution after treatment with…”
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KIT Extracellular and Kinase Domain Mutations in Gastrointestinal Stromal Tumors by Lux, Marcia L., Rubin, Brian P., Biase, Tara L., Chen, Chang-Jie, Maclure, Timothy, Demetri, George, Xiao, Sheng, Singer, Samuel, Fletcher, Christopher D.M., Fletcher, Jonathan A.

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms arising in the gastrointestinal tract. GISTs express the KIT receptor…”
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Gastrointestinal stromal tumours overexpress fatty acid synthase by Rossi, S, Ou, W, Tang, D, Bhattacharya, N, Dei Tos, AP, Fletcher, JA, Loda, M

“…Fatty acid synthase (FASN), a key enzyme for de novo lipogenesis, is overexpressed in many malignant tumours and is associated with aggressive biological…”
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TPM3-ALK and TPM4-ALK Oncogenes in Inflammatory Myofibroblastic Tumors by Lawrence, Brandon, Perez-Atayde, Antonio, Hibbard, Michele K., Rubin, Brian P., Dal Cin, Paola, Pinkus, Jack L., Pinkus, Geraldine S., Xiao, Sheng, Yi, Eunhee S., Fletcher, Christopher D.M., Fletcher, Jonathan A.

“…Inflammatory myofibroblastic tumors (IMTs) are neoplastic mesenchymal proliferations featuring an inflammatory infiltrate composed primarily of lymphocytes and…”
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Aminated Hydroximoyl Camelthorn Residues as a Novel Adsorbent for Extracting Hg(II) From Contaminated Water: Studies of Isotherm, Kinetics, and Mechanism by Hashem, A., Fletcher, A. J., El-Sakhawy, M., Mohamed, Latifa A., Farag, S.

“…Camelthorn, a desert plant, has been utilized as an adsorbent material for the extraction of Hg(II) ions from aqueous solution after grafting with…”
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PLAG1 fusion oncogenes in lipoblastoma by HIBBARD, Michele K, KOZAKEWICH, Harry P, DAL CIN, Paola, SCIOT, Raf, XIAOLIAN TAN, SHENG XIAO, FLETCHER, Jonathan A

“…Lipoblastomas are pediatric neoplasms resulting from transformation of adipocytes. These benign tumors are typically composed of adipose cells in different…”
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Insulin receptor activation in solitary fibrous tumours by Li, Y, Chang, Q, Rubin, BP, Fletcher, CDM, Morgan, TW, Mentzer, SJ, Sugarbaker, DJ, Fletcher, JA, Xiao, S

“…Solitary fibrous tumours (SFTs) are known to overexpress insulin‐like growth factor 2 (IGF‐2). The down‐stream oncogenic pathways of IGF‐2, however, are not…”
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Long-term follow-up results of the multicenter phase II trial of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of standard tyrosine kinase inhibitor therapy by Ben-Ami, E., Barysauskas, C.M., von Mehren, M., Heinrich, M.C., Corless, C.L., Butrynski, J.E., Morgan, J.A., Wagner, A.J., Choy, E., Yap, J.T., Van den Abbeele, A.D., Solomon, S.M., Fletcher, J.A., Demetri, G.D., George, S.

“…This investigator-initiated trial provided the justification for the phase III GRID study resulting in worldwide regulatory approval of regorafenib as a…”
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