Search Results - "Fleszar, Mariusz G."

Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings by Krzystek-Korpacka, Małgorzata, Fleszar, Mariusz G, Bednarz-Misa, Iwona, Lewandowski, Łukasz, Szczuka, Izabela, Kempiński, Radosław, Neubauer, Katarzyna

“…L-arginine/nitric oxide pathway in Crohn's disease (CD) and ulcerative colitis (UC) is poorly investigated. The aim of current study is to quantify pathway…”
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Localization of Sesquiterpene Lactones Biosynthesis in Flowers of Arnica Taxa by Parafiniuk, Agata, Kromer, Krystyna, Fleszar, Mariusz G, Kreitschitz, Agnieszka, Wiśniewski, Jerzy, Gamian, Andrzej

“…is a valuable plant with high demand on the pharmaceutical and cosmetic market due to the presence of helenalin (H) and 11α, 13-dihydrohelenalin (DH)…”
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Simultaneous LC-MS/MS-Based Quantification of Free 3-Nitro-l-tyrosine, 3-Chloro-l-tyrosine, and 3-Bromo-l-tyrosine in Plasma of Colorectal Cancer Patients during Early Postoperative Period by Fleszar, Mariusz G, Fortuna, Paulina, Zawadzki, Marek, Kosyk, Bogna, Krzystek-Korpacka, Małgorzata

“…Quantification with satisfactory specificity and sensitivity of free 3-Nitro-l-tyrosine (3-NT), 3-Chloro-l-tyrosine (3-CT), and 3-Bromo-l-tyrosine (3-BT) in…”
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An analysis of urine and serum amino acids in critically ill patients upon admission by means of targeted LC–MS/MS: a preliminary study by Mierzchała-Pasierb, Magdalena, Lipińska-Gediga, Małgorzata, Fleszar, Mariusz G., Lewandowski, Łukasz, Serek, Paweł, Płaczkowska, Sylwia, Krzystek-Korpacka, Małgorzata

“…Sepsis, defined as a dysregulated host response to infection, causes the interruption of homeostasis resulting in metabolic changes. An examination of patient…”
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The impact of Sample Handling Time on metformin serum concentration by Sutkowska, Edyta, Fortuna, Paulina, Kałuża, Bernadetta, Sutkowska, Karolina, Hodurek, Paweł, Fleszar, Mariusz G.

“…[Display omitted] •The gap between blood sample taking and its centrifugation can have a potential impact on the metformin concentration result.•Two hours gap…”
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Modulation of Prostanoids Profile and Counter-Regulation of SDF-1α/CXCR4 and VIP/VPAC2 Expression by Sitagliptin in Non-Diabetic Rat Model of Hepatic Ischemia-Reperfusion Injury by Krzystek-Korpacka, Małgorzata, Fleszar, Mariusz G, Fortuna, Paulina, Gostomska-Pampuch, Kinga, Lewandowski, Łukasz, Piasecki, Tomasz, Kosyk, Bogna, Szeląg, Adam, Trocha, Małgorzata

“…Molecular mechanisms underlying the beneficial effect of sitagliptin repurposed for hepatic ischemia-reperfusion injury (IRI) are poorly understood. We aimed…”
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Esophageal Squamous Cell Carcinoma Is Accompanied by Local and Systemic Changes in L-arginine/NO Pathway by Bednarz-Misa, Iwona, Fortuna, Paulina, Fleszar, Mariusz G, Lewandowski, Łukasz, Diakowska, Dorota, Rosińczuk, Joanna, Krzystek-Korpacka, Małgorzata

“…The L-arginine/NO pathway holds promise as a source of potential therapy target and biomarker; yet, its status and utility in esophageal squamous cell…”
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Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers by Bednarz-Misa, Iwona, Fleszar, Mariusz G., Fortuna, Paulina, Lewandowski, Łukasz, Mierzchała-Pasierb, Magdalena, Diakowska, Dorota, Krzystek-Korpacka, Małgorzata

“…There is a pressing need for molecular targets and biomarkers in gastric cancer (GC). We aimed at identifying aberrations in L-arginine metabolism with…”
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Sitagliptin Modulates Oxidative, Nitrative and Halogenative Stress and Inflammatory Response in Rat Model of Hepatic Ischemia-Reperfusion by Trocha, Małgorzata, Fleszar, Mariusz G., Fortuna, Paulina, Lewandowski, Łukasz, Gostomska-Pampuch, Kinga, Sozański, Tomasz, Merwid-Ląd, Anna, Krzystek-Korpacka, Małgorzata

“…A possibility of repurposing sitagliptin, a well-established antidiabetic drug, for alleviating injury caused by ischemia-reperfusion (IR) is being researched…”
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Targeted metabolomic analysis of nitric oxide/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes by Fleszar, Mariusz G., Wiśniewski, Jerzy, Zboch, Marzena, Diakowska, Dorota, Gamian, Andrzej, Krzystek-Korpacka, Małgorzata

“…L-Arginine/NO pathway is altered in Alzheimer disease (AD). Its clinical relevance and pathway status in vascular dementia (VaD) are unknown. Using targeted…”
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Solvothermal Alcoholysis Method for Recycling High-Consistency Silicone Rubber Waste by Petrus, Rafał, Utko, Józef, Gniłka, Radosław, Fleszar, Mariusz G, Lis, Tadeusz, Sobota, Piotr

“…In this work, we investigated the potential use of high-consistency silicone rubber (SR), which is a synthetic solid material used in numerous industrial…”
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Altered profiles of serum amino acids in patients with sepsis and septic shock – Preliminary findings by Mierzchala-Pasierb, Magdalena, Lipinska-Gediga, Malgorzata, Fleszar, Mariusz G., Lesnik, Patrycja, Placzkowska, Sylwia, Serek, Pawel, Wisniewski, Jerzy, Gamian, Andrzej, Krzystek-Korpacka, Malgorzata

“…The clinical and diagnostic significance of systemic amino acids in sepsis and septic shock is unclear. Hence, the purpose of our study was to assess amino…”
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Activation of the endocannabinoid system in schizophrenia: A compensatory mechanism of subclinical inflammation? by Misiak, Błażej, Bielawski, Tomasz, Samochowiec, Jerzy, Samochowiec, Agnieszka, Fleszar, Mariusz G., Fortuna, Paulina, Kosyk, Bogna, Frydecka, Dorota

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Alterations in l -arginine metabolism in first-episode schizophrenia patients: Further evidence for early metabolic dysregulation by Misiak, Błażej, Wiśniewski, Jerzy, Fleszar, Mariusz G, Frydecka, Dorota

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Measurement of Serum Levels of 5 Amino Acids and Dimethylamine Using Liquid Chromatography-Tandem Mass Spectrometry in Patients without Septic Associated Acute Kidney Injury and with Septic Associated Acute Kidney Injury Requiring Continuous Renal Replacement Therapy by Leśnik, Patrycja, Łysenko, Lidia, Fleszar, Mariusz G, Fortuna, Paulina, Woźnica-Niesobska, Ewa, Mierzchała-Pasierb, Magdalena, Janc, Jarosław

“…BACKGROUND Acute kidney injury (AKI) is one of the most common organ failures. An early diagnosis of AKI using specific biomarkers is essential for effective…”
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Systemic hepcidin quantified with LC–MS/MS in dementia in association with disease pathology and severity and with structural changes in the brain by Fleszar, Mariusz G., Wiśniewski, Jerzy, Berdowska, Izabela, Zieliński, Bogdan, Zboch, Marzena, Diakowska, Dorota, Gamian, Andrzej, Krzystek-Korpacka, Małgorzata

“…•Neurodegenerative pathology in dementia was associated with significantly lower hepcidin as compared to vascular dementia.•Hepcidin revealed significantly…”
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The iridoid loganic acid and anthocyanins from the cornelian cherry (Cornus mas L.) fruit increase the plasma l-arginine/ADMA ratio and decrease levels of ADMA in rabbits fed a high-cholesterol diet by Sozański, Tomasz, Kucharska, Alicja Z., Wiśniewski, Jerzy, Fleszar, Mariusz G., Rapak, Andrzej, Gomułkiewicz, Agnieszka, Dzięgiel, Piotr, Magdalan, Jan, Nowak, Beata, Szumny, Dorota, Matuszewska, Agnieszka, Piórecki, Narcyz, Szeląg, Adam, Trocha, Małgorzata

“…•Both iridoid loganic acid and to a lesser extent a mixture of anthocyanins from the cornelian cherry fruit increased the l-arginine level in cholesterol-fed…”
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Quantitative Analysis of l-Arginine, Dimethylated Arginine Derivatives, l-Citrulline, and Dimethylamine in Human Serum Using Liquid Chromatography–Mass Spectrometric Method by Fleszar, Mariusz G., Wiśniewski, Jerzy, Krzystek-Korpacka, Małgorzata, Misiak, Błażej, Frydecka, Dorota, Piechowicz, Joanna, Lorenc-Kukuła, Katarzyna, Gamian, Andrzej

“…Nitric oxide (NO) is a small molecule involved in the regulation of many physiological processes. It plays a crucial role in the regulation of nervous system,…”
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L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs by Krzystek-Korpacka, Małgorzata, Szczęśniak-Sięga, Berenika, Szczuka, Izabela, Fortuna, Paulina, Zawadzki, Marek, Kubiak, Agnieszka, Mierzchała-Pasierb, Magdalena, Fleszar, Mariusz G., Lewandowski, Łukasz, Serek, Paweł, Jamrozik, Natalia, Neubauer, Katarzyna, Wiśniewski, Jerzy, Kempiński, Radosław, Witkiewicz, Wojciech, Bednarz-Misa, Iwona

“…L-arginine/nitric oxide pathway metabolites are altered in colorectal cancer (CRC). We evaluated underlying changes in pathway enzymes in 55 paired…”
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L-Arginine/NO Pathway Metabolites in Colorectal Cancer: Relevance as Disease Biomarkers and Predictors of Adverse Clinical Outcomes Following Surgery by Bednarz-Misa, Iwona, Fleszar, Mariusz G., Zawadzki, Marek, Kapturkiewicz, Bartosz, Kubiak, Agnieszka, Neubauer, Katarzyna, Witkiewicz, Wojciech, Krzystek-Korpacka, Małgorzata

“…The L-Arginine/NO pathway is involved in carcinogenesis and immunity. Its diagnostic and prognostic value in colorectal cancer (CRC) was determined using…”
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