Search Results - "Fless, Gunther M."

Genotype-Specific Transcriptional Regulation of PAI-1 Expression by Hypertriglyceridemic VLDL and Lp(a) in Cultured Human Endothelial Cells by Li, Xin-Nong, Grenett, Hernan E, Benza, Raymond L, Demissie, Sossiena, Brown, Stephen L, Tabengwa, Edlue M, Gianturco, Sandra H, Bradley, William A, Fless, Gunther M, Booyse, Francois M

“…The hypothesized relationships between plasminogen activator inhibitor (PAI-1) genotypes, PAI-1 levels, and their potential regulation by hypertriglyceridemic…”
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cDNA sequence of human apolipoprotein(a) is homologous to plasminogen by McLean, John W, Tomlinson, James E, Kuang, Wun-Jing, Eaton, Dan L, Chen, Ellson Y, Fless, Gunther M, Scanu, Angelo M, Lawn, Richard M

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Tissue-type plasminogen activator binds to and is inhibited by surface-bound lipoprotein(a) and low-density lipoprotein by Simon, Daniel I, Fless, Gunther M, Scanu, Angelo M, Loscalzo, Joseph

“…Elevated levels of lipoprotein(a) [Lp(a)] are associated with an increased risk of atherothrombotic disease, but the mechanism(s) by which Lp(a) potentiates…”
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Effect of phospholipase A2 digestion on the conformation and lysine/fibrinogen binding properties of human lipoprotein[a] by Fless, Gunther M., Kirk, Elliot W., Klezovitch, Olga, Santiago, José Y., Edelstein, Celina, Hoover-Plow, Jane, Scanu, Angelo M.

“…In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased…”
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A potential basis for the thrombotic risks associated with lipoprotein( a ) by Miles, Lindsey A, Fless, Gunther M, Levin, Eugene G, Scanu, Angelo M, Plow, Edward F

“…Lipoprotein(a) (Lp(a)) has been strongly linked with atherosclerosis and is an independent risk factor for myocardial infarction. Distinguishing Lp(a) from…”
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Genotype-Specific Transcriptional Regulation of PAI-1 Gene by Insulin, Hypertriglyceridemic VLDL, and Lp(a) in Transfected, Cultured Human Endothelial Cells by Grenett, Hernan E, Benza, Raymond L, Fless, Gunther M, Li, Xin-Nong, Davis, Glenda C, Booyse, Francois M

“…Plasminogen activator inhibitor-1 (PAI-1) has been shown to be an independent risk factor for coronary artery disease. Variations in plasma PAI-1 levels have…”
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The Relationship between the Effect of Lysine Analogues and Salt on the Conformation of Lipoprotein(a) by Fless, Gunther M, Halfman, Clarke J, Kirk, Elliot W

“…Lipoprotein(a) [Lp(a)] exhibits many of the same properties as plasminogen, owing to a similar structural makeup from a composite of multiple kringle domains…”
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Subunit Composition of Lipoprotein(a) Protein by Fless, Gunther M, Snyder, Margaret L, Furbee, J. W, Garcia-Hedo, Maria-Teresa, Mora, Rene

“…We determined the molecular weight of four different apo(a) polymorphs by sedimentation equilibrium in 6 M guanidine hydrochloride in order to estimate the…”
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Comparison of the lysine binding functions of lipoprotein(a) and plasminogen by Hoover-Plow, Jane L, Miles, Lindsey A, Fless, Gunther M, Scanu, Angelo M, Plow, Edward F

“…Regions of apoprotein(a) of lipoprotein(a) [Lp(a)] exhibit striking primary sequence homology to the kringles of plasminogen. The kringles of plasminogen are…”
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Molecular Weight Determination of Lipoprotein(a) [Lp(a)] in Solutions Containing either NaBr or D2O:  Relevance to the Number of Apolipoprotein(a) Subunits in Lp(a) by Fless, Gunther M, Santiago, José Y

“…Molecular weight determination of low-density lipoprotein (LDL) is usually performed in solutions containing high concentrations of salt (up to 13.4 M NaBr) by…”
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Effect of Glycation on the Properties of Lipoprotein(a) by Makino, Kazuhiko, Furbee, Jr, Scanu, Angelo M, Fless, Gunther M

“…Lipoprotein(a) [Lp(a)] was glycated by incubation in vitro with glucose (0 to 200 mmol/L), and its properties were compared with native Lp(a) and native and…”
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Plasma lipoprotein (a) protein concentration and coronary artery disease in black patients compared with white patients by Sorrentino, M J, Vielhauer, C, Eisenbart, J D, Fless, G M, Scanu, A M, Feldman, T

“…This study examines the relation between lipoprotein (a) protein levels and other lipid parameters and coronary artery disease in white and black patients…”
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Cellular binding and degradation of lipoprotein (a) by Fless, G M

“…Lp(a) is an important contributing factor to the development of atherosclerosis, and in structure is similar to LDL. Given the central role of the LDL receptor…”
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Ligand-Induced Conformational Change of Lipoprotein(a) by Fless, Gunther M, Furbee, James, Snyder, Margaret L, Meredith, Stephen C

“…Lipoprotein(a) undergoes a dramatic, reversible conformational change on binding 6-aminohexanoic acid (6-AHA), as measured by a decrease in the sedimentation…”
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Structure−Function Relationships in Side Chain Lactam Cross-Linked Peptide Models of a Conserved N-Terminal Domain of Apolipoprotein E by Benzinger, Tammie L. S, Braddock, Demetrios T, Dominguez, Samuel R, Burkoth, Timothy S, Miller-Auer, Hélène, Subramanian, Ram M, Fless, Gunther M, Jones, David N. M, Lynn, David G, Meredith, Stephen C

“…Bioactive peptides have multiple conformations in solution but adopt well-defined conformations at lipid surfaces and in interactions with receptors. We have…”
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Specificity of Ligand-Induced Conformational Change of Lipoprotein(a) by Fless, Gunther M, Santiago, José Y, Furbee, James, Meredith, Stephen C

“…The conformation of Lp(a) was probed with a set of ω-aminocarboxylic acids and other analogs of 6-aminohexanoic acid (6-AHA). Using the viscosity-corrected…”
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Lipoprotein (a) : heterogeneity and biological relevance by SCANU, A. M, FLESS, G. M

“…Lipoprotein (a), or Lp(a), discovered by Kaare Berg more than 25 years ago, remains today a fascinating subject of research both because of its presumed…”
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Study of abnormal plasma low-density lipoprotein in rhesus monkeys with diet-induced hyperlipidemia by Fless, Gunther M, Wissler, Robert W, Scanu, Angelo M

“…Male rhesus monkeys were divided into three groups: five were fed a regular primate chow diet and were used as controls; four received an "average" American…”
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Physicochemical characterization of rhesus low density lipoproteins by Fless, Gunther M, Scanu, Angelo M

“…The serum low density lipoprotein (LDL; p 1.019-1.050 g/ml) of the normal Macaca mulatta monkey (rhesus), kept on a low-fat Purina primate chow diet, was…”
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Mechanisms by which lipoprotein lipase alters cellular metabolism of lipoprotein(a), low density lipoprotein, and nascent lipoproteins. Roles for low density lipoprotein receptors and heparan sulfate proteoglycans by WILLIAMS, K. J, FLESS, G. M, PETRIE, K. A, SNYDER, M. L, BROCIA, R. W, SWENSON, T. L

“…We sought to investigate effects of lipoprotein lipase (LpL) on cellular catabolism of lipoproteins rich in apolipoprotein B-100. LpL increased cellular…”
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