Search Results - "Flesch, Inge E A"

Kinetics of antigen expression and epitope presentation during virus infection by Croft, Nathan P, Smith, Stewart A, Wong, Yik Chun, Tan, Chor Teck, Dudek, Nadine L, Flesch, Inge E A, Lin, Leon C W, Tscharke, David C, Purcell, Anthony W

“…Current knowledge about the dynamics of antigen presentation to T cells during viral infection is very poor despite being of fundamental importance to our…”
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Analysis of A47, an Immunoprevalent Protein of Vaccinia Virus, Leads to a Reevaluation of the Total Antiviral CD8+ T Cell Response by YUEN, Tracy J, FLESCH, Inge E. A, HOLLETT, Natasha A, DOBSON, Bianca M, RUSSELL, Tiffany A, FAHRER, Aude M, TSCHARKE, David C

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An intact signal peptide on dengue virus E protein enhances immunogenicity for CD8+ T cells and antibody when expressed from modified vaccinia Ankara by Quinan, Bárbara R, Flesch, Inge E.A, Pinho, Tânia M.G, Coelho, Fabiana M, Tscharke, David C, da Fonseca, Flávio G

“…Highlights • MVA vectored dengue vaccines were explored for their CD8+ T cells immunogenicity. • We identified two H-2b -restricted DENV-3 E protein-specific…”
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Vaccinia Virus CD8+ T-Cell Dominance Hierarchies Cannot Be Altered by Prior Immunization with Individual Peptides by YANG WANG, FLESCH, Inge E. A, TSCHARKE, David C

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Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus by Flesch, Inge E A, Hollett, Natasha A, Wong, Yik Chun, Quinan, Bárbara Resende, Howard, Debbie, da Fonseca, Flávio G, Tscharke, David C

“…CD8(+) T cells that recognize virus-derived peptides presented on MHC class I are vital antiviral effectors. Such peptides presented by any given virus vary…”
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Linear fidelity in quantification of anti-viral CD8+ T cells by Flesch, Inge E A, Hollett, Natasha A, Wong, Yik Chun, Tscharke, David C

“…Enumeration of anti-viral CD8(+) T cells to make comparisons between mice, viruses and vaccines is a frequently used approach, but controversy persists as to…”
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Delayed control of herpes simplex virus infection and impaired CD4+ T‐cell migration to the skin in mouse models of DOCK8 deficiency by Flesch, Inge E A, Randall, Katrina L, Hollett, Natasha A, Di Law, Hsei, Miosge, Lisa A, Sontani, Yovina, Goodnow, Christopher C, Tscharke, David C

“…DOCK8 deficiency in humans and mice leads to multiple defects in immune cell numbers and function. Patients with this immunodeficiency have a high morbidity…”
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Most viral peptides displayed by class I MHC on infected cells are immunogenic by Croft, Nathan P., Smith, Stewart A., Pickering, Jana, Sidney, John, Peters, Bjoern, Faridi, Pouya, Witney, Matthew J., Sebastian, Prince, Flesch, Inge E. A., Heading, Sally L., Sette, Alessandro, La Gruta, Nicole L., Purcell, Anthony W., Tscharke, David C.

“…CD8⁺ T cells are essential effectors in antiviral immunity, recognizing short virus-derived peptides presented by MHC class I (pMHCI) on the surface of…”
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Vaccinia virus F5 is required for normal plaque morphology in multiple cell lines but not replication in culture or virulence in mice by Dobson, Bianca M, Procter, Dean J, Hollett, Natasha A, Flesch, Inge E.A, Newsome, Timothy P, Tscharke, David C

“…Abstract Vaccinia virus (VACV) gene F5L was recently identified as a determinant of plaque morphology that is truncated in Modified Vaccinia virus Ankara…”
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Immunodomination during peripheral vaccinia virus infection by Lin, Leon C W, Flesch, Inge E A, Tscharke, David C

“…Immunodominance is a fundamental property of CD8(+) T cell responses to viruses and vaccines. It had been observed that route of administration alters…”
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Surprisingly Effective Priming of CD8 + T Cells by Heat-Inactivated Vaccinia Virus Virions by Croft, Sarah, Wong, Yik Chun, Smith, Stewart A, Flesch, Inge E A, Tscharke, David C

“…Robust priming of CD8 T cells by viruses is considered to require infection and expression of viral antigens. A corollary of this is that inactivated viruses…”
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DOCK2 Deficiency Causes Defects in Antiviral T-Cell Responses and Impaired Control of Herpes Simplex Virus Infection by Randall, Katrina L, Flesch, Inge E A, Mei, Yan, Miosge, Lisa A, Aye, Racheal, Yu, Zhijia, Domaschenz, Heather, Hollett, Natasha A, Russell, Tiffany A, Stefanovic, Tijana, Wong, Yik Chun, Seneviratne, Sandali, Ballard, Fiona, Hernandez Gallardo, Raquel, Croft, Sarah N, Goodnow, Christopher C, Bertram, Edward M, Enders, Anselm, Tscharke, David C

“…Abstract The expanding number of rare immunodeficiency syndromes offers an opportunity to understand key genes that support immune defense against infectious…”
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MIP-1α, MIP-1β, RANTES, and ATAC/Lymphotactin Function Together with IFN-γ as Type 1 Cytokines by Dorner, Brigitte G., Scheffold, Alexander, Rolph, Michael S., Hüser, Martin B., Stefan H. E. Kaufmann, Radbruch, Andreas, Inge E. A. Flesch, Kroczek, Richard A.

“…We analyzed for the first time the expression of chemokines in subpopulations of the murine immune system at the single-cell level. We demonstrate in vitro and…”
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Growth inhibition of Mycobacterium bovis by IFN-gamma stimulated macrophages: regulation by endogenous tumor necrosis factor-alpha and by IL-10 by Flesch, I E, Hess, J H, Oswald, I P, Kaufmann, S H

“…Murine bone marrow-derived macrophages (BMM) are able to inhibit the intracellular growth of Mycobacterium bovis and Mycobacterium tuberculosis H37Rv after…”
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Analyzing CD8 T cells in mouse models of poxvirus infection by Flesch, Inge E A, Wong, Yik Chun, Tscharke, David C

“…Mouse models of immunology are frequently used to study host responses to poxviruses or poxvirus-based recombinant vaccines. In this context, the magnitude of…”
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NADPH diaphorase staining suggests a transient and localized contribution of nitric oxide to host defence against an intracellular pathogen in situ by Flesch, I E, Hess, J H, Kaufmann, S H

“…Nitric oxide (NO) is formed constitutively in neurons by the constitutive enzyme NO synthase (cNOS) and acts as a neurotransmitter. It has already been shown…”
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Characterization of colonic and mesenteric lymph node dendritic cell subpopulations in a murine adoptive transfer model of inflammatory bowel disease by Karlis, John, Penttila, Irmeli, Tran, Tuyet B, Jones, Ben, Nobbs, Silvia, Zola, Heddy, Flesch, Inge EA

“…Ulcerative colitis and Crohn's disease, collectively termed inflammatory bowel diseases (IBD), are chronic inflammatory diseases of the intestine that afflict…”
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Monocyte inflammatory protein-1α facilitates priming of CD8+ T cell responses to exogenous viral antigen by Flesch, Inge E. A., Stober, Detlef, Schirmbeck, Reinhold, Reimann, Jörg

“…Dendritic cells (DC) derived from bone marrow precursors of BALB/c or C57BL/6 mice in low-serum cultures supplemented with granulocyte macrophage colony…”
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Altered CD8+ T Cell Immunodominance after Vaccinia Virus Infection and the Naive Repertoire in Inbred and F1 Mice by Flesch, Inge E. A., Woo, Wai-Ping, Wang, Yang, Panchanathan, Vijay, Wong, Yik-Chun, La Gruta, Nicole L., Cukalac, Tania, Tscharke, David C.

“…Abstract Previous studies of CD8+ T cell immunodominance after primary virus infection of F1 mice compared with their inbred parents have generally concluded…”
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Linear Fidelity in Quantification of Anti-Viral CD8.sup.+ T Cells by Flesch, Inge E. A, Hollett, Natasha A, Wong, Yik Chun, Tscharke, David C

“…Enumeration of anti-viral CD8.sup.+ T cells to make comparisons between mice, viruses and vaccines is a frequently used approach, but controversy persists as…”
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