Search Results - "Flens, M. J."

Extramural Venous Invasion as Prognostic Factor of Recurrence in Stage 1 and 2 Colon Cancer by Loffeld, Ruud J. L. F., Mulder, M. M. R., Flens, M. J., van Eeghen, E. E.

“…Aim. Extramural venous invasion (EMVI) is a prognostic indicator in patients with colorectal cancer. However, its additional value in patients with stage 1 and…”
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Tissue distribution of the multidrug resistance protein by Flens, MJ, Zaman, GJ, van der Valk, P, Izquierdo, MA, Schroeijers, AB, Scheffer, GL, van der Groep, P, de Haas, M, Meijer, CJ, Scheper, RJ

“…The human multidrug resistance protein (MRP) is a 190 kd membrane glycoprotein that can cause resistance of human tumor cells to various anticancer drugs, by…”
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The Human Multidrug Resistance-Associated Protein MRP is a Plasma Membrane Drug-Efflux Pump by Zaman, G. J. R., Flens, M. J., van Leusden, M. R., de Haas, M., Mulder, H. S., Lankelma, J., Pinedo, H. M., Scheper, R. L., Baas, F., broxterman, H. J., Borst, P.

“…The multidrug-resistance associated protein MRP is a 180- to 195-kDa membrane protein associated with resistance of human tumor cells to cytotoxic drugs. We…”
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Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma by Izquierdo, M A, van der Zee, A G, Vermorken, J B, van der Valk, P, Beliën, J A, Giaccone, G, Scheffer, G L, Flens, M J, Pinedo, H M, Kenemans, P

“…Drug resistance is a major impediment to the successful treatment of ovarian carcinoma. None of the earlier-identified resistance mechanisms, such as…”
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The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer by NOOTER, K, BRUTEL DE LA RIVIERE, G, LOOK, M. P, VAN WINGERDEN, K. E, HENZEN-LOGMANS, S. C, SCHEPER, R. J, FLENS, M. J, KLIJN, J. G. M, STOTER, G, FOEKENS, J. A

“…In the present study, we determined the frequency and intensity of MRP protein expression by monoclonal antibody immunohistochemistry in a series of 259…”
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Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors by Izquierdo, MA, Scheffer, GL, Flens, MJ, Giaccone, G, Broxterman, HJ, Meijer, CJ, van der Valk, P, Scheper, RJ

“…Multidrug resistance (MDR) to anticancer drugs is a major cause of treatment failure in cancer. The lung resistance protein LRP is a newly described protein…”
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Expression of the multidrug resistance-associated protein (MRP) gene in human cancers by NOOTER, K, WESTERMAN, A. M, GRATAMA, J. W, KOK, T, EGGERMONT, A. M. M, BOSMAN, F. T, STOTER, G, FLENS, M. J, ZAMAN, G. J. R, SCHEPER, R. J, VAN WINGERDEN, K. E, BURGER, H, OOSTRUM, R, BOERSMA, T, SONNEVELD, P

“…We determined the expression of a newly recognized drug resistance gene, the multidrug resistance-associated protein (MRP) gene, [Cole et al., Science…”
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Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis by Meijer, G A, Schroeijers, A B, Flens, M J, Meuwissen, S G, van der Valk, P, Baak, J P, Scheper, R J

“…AIM: To analyse the expression of multidrug resistance (MDR) related proteins at different steps in colorectal carcinogenesis. METHODS: The presence of three…”
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Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies by FLENS, M. J, IZQUIERDO, M. A, SCHEFFER, G. I, FRITZ, J. M, MEIJER, C. J. L. M, SCHEPER, R. J, ZAMAN, G. J. R

“…We have generated rat and murine monoclonal antibodies against multidrug resistance-associated protein (MRP), a M(r) 180,000-195,000 membrane glycoprotein…”
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Case 2. Intracardiac metastasis from a Merkel cell carcinoma by JONGBLOED, M. R. M, KANEN, B. L. J, VISSER, M, NIESSEN, H, FLENS, M. J, LOFFELD, R. J. L. F

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Membrane transport proteins associated with drug resistance expressed in human melanoma by Schadendorf, D, Makki, A, Stahr, C, van Dyck, A, Wanner, R, Scheffer, GL, Flens, MJ, Scheper, R, Henz, BM

“…Melanoma cells often display a multidrug-resistant phenotype, but the mechanisms involved are largely unknown. We have studied here the recently identified…”
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Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer by Nooter, K., Bosman, F. T., Burger, H., van Wingerden, K. E., Flens, M. J., Scheper, R. J., Oostrum, R. G., Boersma, A. W. M., Gaast, A. van der, Stoter, G.

“…Background One of the major problems in the cure of advanced non-small-cell lung cancer (NSCLC) is its lack of re sponse to cytotoxic drug treatment, and the…”
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Increased expression of beta 2-microglobulin in multidrug-resistant tumour cells by SCHEFFER, G. L, DE KONG, M. C, MONKS, A, FLENS, M. J, HOSE, C. D, IZQUIERDO, M. A, SHOEMAKER, R. H, SCHEPER, R. J

“…The rat monoclonal antibody LMR-12 was shown earlier to react with a plasma membrane protein, upregulated in multidrug-resistant cell lines. In this study, we…”
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Major vault protein LRP-related multidrug resistance by Izquierdo, M.A., Scheffer, G.L., Flens, M.J., Schroeijers, A.B., van der Valk, P., Scheper, R.J.

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Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia by Den Boer, M L, Zwaan, C M, Pieters, R, Kazemier, K M, Rottier, M M, Flens, M J, Scheper, R J, Veerman, A J

“…The clinical relevance of multidrug resistance (MDR)-related proteins in childhood acute lymphoblastic leukemia (ALL) is largely unknown. The diversity of…”
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Overexpression of the ABC transporter TAP in multidrug-resistant human cancer cell lines by IZQUIERDO, M. A, NEEFJES, J. J, MATHARI, A. E. L, FLENS, M. J, SCHEFFER, G. L, SCHEPER, R. J

“…Multidrug resistance (MDR) to anti-cancer drugs has been associated with the overexpression of P-glycoprotein (P-gp) and the multidrug resistance-associated…”
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Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines by WELTERS, M. J. P, FICHTINGER-SCHEPMAN, A. M. J, BAAN, R. A, FLENS, M. J, SCHEPER, R. J, BRAAKHUIS, B. J. M

“…Resistance to chemotherapy is a major problem in the treatment of patients with head and neck squamous cell carcinoma (HNSCC). Important factors involved are…”
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Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin by DOLFINI, E, DASDIA, T, ARANCIA, G, MOLINARI, A, CALCABRINI, A, SCHEPER, R. J, FLENS, M. J, GARIBOLDI, M. B, MONTI, E

“…Intrinsic low-level resistance to anti-cancer drugs is a major problem in the treatment of gastrointestinal malignancies. To address the problem presented by…”
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Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues by Schroeijers, AB, Scheffer, GL, Flens, MJ, Meijer, GA, Izquierdo, MA, van der Valk, P, Scheper, RJ

“…Multidrug resistant cancer cells frequently overexpress the 110-kd lung resistance-related protein (LRP) as detected with the monoclonal antibody (MAb) LRP-56…”
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Collagenous colitis: Description of a single centre series of 83 patients by Jobse, P, Flens, M.J, Loffeld, R.J.L.F

“…Abstract Introduction Collagenous colitis can be the cause of chronic diarrhoea. Aim Assess the prevalence of collagenous colitis in a single centre. Patients…”
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