Search Results - "Fleming, M."

Distinct encoding of decision confidence in human medial prefrontal cortex by Bang, Dan, Fleming, Stephen M.

“…Our confidence in a choice and the evidence pertaining to a choice appear to be inseparable. However, an emerging computational consensus holds that the brain…”
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Domain-General and Domain-Specific Patterns of Activity Supporting Metacognition in Human Prefrontal Cortex by Morales, Jorge, Lau, Hakwan, Fleming, Stephen M

“…Metacognition is the capacity to evaluate the success of one's own cognitive processes in various domains; for example, memory and perception. It remains…”
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Interplay of Guanine Oxidation and G‑Quadruplex Folding in Gene Promoters by Fleming, Aaron M, Burrows, Cynthia J

“…Living in an oxygen atmosphere demands an ability to thrive in the presence of reactive oxygen species (ROS). Aerobic organisms have successfully found…”
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Self-Evaluation of Decision-Making: A General Bayesian Framework for Metacognitive Computation by Fleming, Stephen M, Daw, Nathaniel D

“…People are often aware of their mistakes, and report levels of confidence in their choices that correlate with objective performance. These metacognitive…”
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How to measure metacognition by Fleming, Stephen M, Lau, Hakwan C

“…The ability to recognize one's own successful cognitive processing, in e.g., perceptual or memory tasks, is often referred to as metacognition. How should we…”
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Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair by Fleming, Aaron M., Ding, Yun, Burrows, Cynthia J.

“…Reactive oxygen species (ROS) have emerged as important cellular-signaling agents for cellular survival. Herein, we demonstrate that ROS-mediated oxidation of…”
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On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics by Fleming, Aaron M, Burrows, Cynthia J

“…Contrary to frequent reports in the literature, hydroxyl radical is not a key species participating in endogenous oxidative DNA damage. Instead, carbonate…”
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The neural basis of metacognitive ability by Fleming, Stephen M., Dolan, Raymond J.

“…Ability in various cognitive domains is often assessed by measuring task performance, such as the accuracy of a perceptual categorization. A similar analysis…”
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Subjective signal strength distinguishes reality from imagination by Dijkstra, Nadine, Fleming, Stephen M.

“…Humans are voracious imaginers, with internal simulations supporting memory, planning and decision-making. Because the neural mechanisms supporting imagery…”
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Perceptual reality monitoring: Neural mechanisms dissociating imagination from reality by Dijkstra, Nadine, Kok, Peter, Fleming, Stephen M.

“…There is increasing evidence that imagination relies on similar neural mechanisms as externally triggered perception. This overlap presents a challenge for…”
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HMeta-d: hierarchical Bayesian estimation of metacognitive efficiency from confidence ratings by Fleming, Stephen M

“…Abstract Metacognition refers to the ability to reflect on and monitor one’s cognitive processes, such as perception, memory and decision-making. Metacognition…”
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Formation and processing of DNA damage substrates for the hNEIL enzymes by Fleming, Aaron M., Burrows, Cynthia J.

“…Reactive oxygen species (ROS) are harnessed by the cell for signaling at the same time as being detrimental to cellular components such as DNA. The genome and…”
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Integrated analysis of multimodal single-cell data by Hao, Yuhan, Hao, Stephanie, Andersen-Nissen, Erica, Mauck, William M., Zheng, Shiwei, Butler, Andrew, Lee, Maddie J., Wilk, Aaron J., Darby, Charlotte, Zager, Michael, Hoffman, Paul, Stoeckius, Marlon, Papalexi, Efthymia, Mimitou, Eleni P., Jain, Jaison, Srivastava, Avi, Stuart, Tim, Fleming, Lamar M., Yeung, Bertrand, Rogers, Angela J., McElrath, Juliana M., Blish, Catherine A., Gottardo, Raphael, Smibert, Peter, Satija, Rahul

“…The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can…”
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Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices by Halldorsson, Skarphedinn, Lucumi, Edinson, Gómez-Sjöberg, Rafael, Fleming, Ronan M.T.

“…Culture of cells using various microfluidic devices is becoming more common within experimental cell biology. At the same time, a technological radiation of…”
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Sequencing the Mouse Genome for the Oxidatively Modified Base 8‑Oxo-7,8-dihydroguanine by OG-Seq by Ding, Yun, Fleming, Aaron M, Burrows, Cynthia J

“…Oxidative damage to the genome can yield the base 8-oxo-7,8-dihydroguanine (OG). In vitro studies suggested OG would preferentially form in 5′-GG-3′ sequence…”
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Forming global estimates of self-performance from local confidence by Rouault, Marion, Dayan, Peter, Fleming, Stephen M.

“…Metacognition, the ability to internally evaluate our own cognitive performance, is particularly useful since many real-life decisions lack immediate feedback…”
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Metacognitive Computations for Information Search: Confidence in Control by Schulz, Lion, Fleming, Stephen M., Dayan, Peter

“…The metacognitive sense of confidence can play a critical role in regulating decision making. In particular, a lack of confidence can justify the explicit,…”
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Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression by Stephan, Klaas E, Manjaly, Zina M, Mathys, Christoph D, Weber, Lilian A E, Paliwal, Saee, Gard, Tim, Tittgemeyer, Marc, Fleming, Stephen M, Haker, Helene, Seth, Anil K, Petzschner, Frederike H

“…This paper outlines a hierarchical Bayesian framework for interoception, homeostatic/allostatic control, and meta-cognition that connects fatigue and…”
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Prefrontal contributions to metacognition in perceptual decision making by Fleming, Stephen M, Huijgen, Josefien, Dolan, Raymond J

“…Neuroscience has made considerable progress in understanding the neural substrates supporting cognitive performance in a number of domains, including memory,…”
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Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution by Khoddami, Vahid, Yerra, Archana, Mosbruger, Timothy L., Fleming, Aaron M., Burrows, Cynthia J., Cairns, Bradley R.

“…The breadth and importance of RNA modifications are growing rapidly as modified ribonucleotides can impact the sequence, structure, function, stability, and…”
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