Search Results - "Fleming, Jonathan T."

The Purkinje Neuron Acts as a Central Regulator of Spatially and Functionally Distinct Cerebellar Precursors by Fleming, Jonathan T., He, Wenjuan, Hao, Chuanming, Ketova, Tatiana, Pan, Fong C., Wright, Christopher C.V., Litingtung, Ying, Chiang, Chin

“…The prospective white matter (PWM) in the nascent cerebellum contains a transient germinal compartment that produces all postnatally born GABAergic inhibitory…”
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Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture by Cheng, Frances Y., Fleming, Jonathan T., Chiang, Chin

“…Neuronal-glial relationships play a critical role in the maintenance of central nervous system architecture and neuronal specification. A deeper understanding…”
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Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development by Huang, Xi, Liu, Jiang, Ketova, Tatiana, Fleming, Jonathan T, Grover, Vandana K, Cooper, Michael K, Litingtung, Ying, Chiang, Chin

“…Cerebellar neurons are generated from two germinal neuroepithelia: the ventricular zone (VZ) and rhombic lip. Signaling mechanisms that maintain the…”
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Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus by Huang, Xi, Ketova, Tatiana, Fleming, Jonathan T, Wang, Haibin, Dey, Sudhansu K, Litingtung, Ying, Chiang, Chin

“…Choroid plexuses (ChPs) are vascularized secretory organs involved in the regulation of brain homeostasis, and function as the blood-cerebrospinal fluid (CSF)…”
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An In Vivo Chemical Genetic Screen Identifies Phosphodiesterase 4 as a Pharmacological Target for Hedgehog Signaling Inhibition by Williams, Charles H., Hempel, Jonathan E., Hao, Jijun, Frist, Audrey Y., Williams, Michelle M., Fleming, Jonathan T., Sulikowski, Gary A., Cooper, Michael K., Chiang, Chin, Hong, Charles C.

“…Hedgehog (Hh) signaling plays an integral role in vertebrate development, and its dysregulation has been accepted widely as a driver of numerous malignancies…”
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Expression and localization of myosin-1d in the developing nervous system by Benesh, Andrew E, Fleming, Jonathan T, Chiang, Chin, Carter, Bruce D, Tyska, Matthew J

“…Abstract Myosin-1d is a monomeric actin-based motor found in a wide range of tissues, but highly expressed in the nervous system. Previous microarray studies…”
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Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning by Li, Wen, Chen, Lei, Fleming, Jonathan T, Brignola, Emily, Zavalin, Kirill, Lagrange, Andre, Rex, Tonia, Heiney, Shane A, Wojaczynski, Gregory J, Medina, Javier F, Chiang, Chin

“…Cerebellar inhibitory interneurons are important regulators of neural circuit activity for diverse motor and nonmotor functions. The molecular layer…”
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Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex by Ryan, Kaitlyn E., Kim, Patrick S., Fleming, Jonathan T., Brignola, Emily, Cheng, Frances Y., Litingtung, Ying, Chiang, Chin

“…Cerebellar growth and foliation require the Hedgehog-driven proliferation of granule cell precursors (GCPs) in the external granule layer (EGL). However, that…”
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Insight into the Etiology of Undifferentiated Soft Tissue Sarcomas from a Novel Mouse Model by Fleming, Jonathan T, Brignola, Emily, Chen, Lei, Guo, Yan, Zhao, Shilin, Wang, Quan, Li, Bingshan, Correa, Hernán, Ermilov, Alexandre N, Dlugosz, Andrzej A, Chiang, Chin

“…Aberrant activation of the Hedgehog signaling pathway has been linked to the formation of numerous cancer types, including the myogenic soft tissue sarcoma,…”
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BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma by Loganathan, Sudan N, Tang, Nan, Fleming, Jonathan T, Ma, Yufang, Guo, Yan, Borinstein, Scott C, Chiang, Chin, Wang, Jialiang

“…Ewing sarcoma is driven by characteristic chromosomal translocations between the EWSR1 gene with genes encoding ETS family transcription factors (EWS-ETS),…”
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BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma by Loganathan, Sudan N., Tang, Nan, Fleming, Jonathan T., Ma, Yufang, Guo, Yan, Borinstein, Scott C., Chiang, Chin, Wang, Jialiang

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