Search Results - "Fleming, Jennifer R"

Guanidino acid hydrolysis by the human enzyme annotated as agmatinase by Sinn, Malte, Stanoppi, Marco, Hauth, Franziskus, Fleming, Jennifer R., Funck, Dietmar, Mayans, Olga, Hartig, Jörg S.

“…Guanidino acids such as taurocyamine, guanidinobutyrate, guanidinopropionate, and guanidinoacetate have been detected in humans. However, except for…”
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Pairwise sequence similarity mapping with PaSiMap: Reclassification of immunoglobulin domains from titin as case study by Su, Kathy, Mayans, Olga, Diederichs, Kay, Fleming, Jennifer R.

“…[Display omitted] •A novel multidimensional scaling pipeline for sequence analysis.•A simple way to distinguish between unique and shared sequence…”
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The ZT Biopolymer: A Self-Assembling Protein Scaffold for Stem Cell Applications by Nesterenko, Yevheniia, Hill, Christopher J, Fleming, Jennifer R, Murray, Patricia, Mayans, Olga

“…The development of cell culture systems for the naturalistic propagation, self-renewal and differentiation of cells ex vivo is a high goal of molecular…”
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Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis by Stergiou, Christos, Williams, Rhys, Fleming, Jennifer R, Zouvelou, Vasiliki, Ninou, Elpinickie, Andreetta, Francesca, Rinaldi, Elena, Simoncini, Ornella, Mantegazza, Renato, Bogomolovas, Julius, Tzartos, John, Labeit, Siegfried, Mayans, Olga, Tzartos, Socrates

“…Myasthenia gravis (MG) is an autoimmune disease caused by antibodies targeting the neuromuscular junction (NJ) of skeletal muscles. The major MG autoantigen is…”
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Exploring Obscurin and SPEG Kinase Biology by Fleming, Jennifer R, Rani, Alankrita, Kraft, Jamie, Zenker, Sanja, Börgeson, Emma, Lange, Stephan

“…Three members of the obscurin protein family that contain tandem kinase domains with important signaling functions for cardiac and striated muscles are the…”
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Proteomic Identification of Immunodiagnostic Antigens for Trypanosoma vivax Infections in Cattle and Generation of a Proof-of-Concept Lateral Flow Test Diagnostic Device by Fleming, Jennifer R, Sastry, Lalitha, Wall, Steven J, Sullivan, Lauren, Ferguson, Michael A J

“…Trypanosoma vivax is one of the causative agents of Animal African Trypanosomosis in cattle, which is endemic in sub-Saharan Africa and transmitted primarily…”
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Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I by Bogomolovas, Julius, Fleming, Jennifer R., Anderson, Brian R., Williams, Rhys, Lange, Stephan, Simon, Bernd, Khan, Muzamil M., Rudolf, Rüdiger, Franke, Barbara, Bullard, Belinda, Rigden, Daniel J., Granzier, Henk, Labeit, Siegfried, Mayans, Olga

“…Missense single-nucleotide polymorphisms (mSNPs) in titin are emerging as a main causative factor of heart failure. However, distinguishing between benign and…”
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Proteomic selection of immunodiagnostic antigens for Trypanosoma congolense by Fleming, Jennifer R, Sastry, Lalitha, Crozier, Thomas W M, Napier, Grant B, Sullivan, Lauren, Ferguson, Michael A J

“…Animal African Trypanosomosis (AAT) presents a severe problem for agricultural development in sub-Saharan Africa. It is caused by several trypanosome species…”
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AMP-dependent phosphite dehydrogenase, a phosphorylating enzyme in dissimilatory phosphite oxidation by Mao, Zhuqing, Fleming, Jennifer R, Mayans, Olga, Frey, Jasmin, Schleheck, David, Schink, Bernhard, Müller, Nicolai

“…Oxidation of phosphite (HPO ) to phosphate (HPO ) releases electrons at a very low redox potential (E = -690 mV) which renders phosphite an excellent electron…”
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Molecular insights into titin’s A-band by Fleming, Jennifer R., Müller, Iljas, Zacharchenko, Thomas, Diederichs, Kay, Mayans, Olga

“…The thick filament-associated A-band region of titin is a highly repetitive component of the titin chain with important scaffolding properties that support…”
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Titin UN2A acts as a stable, non-polymorphic scaffold in its binding to CARP by Stehle, Juliane, Fleming, Jennifer R, Bauer, Piera-Maria, Mayans, Olga, Drescher, Malte

“…The N2A segment of titin functions as a pivotal hub for signal transduction and interacts with various protein involved in structural support, chaperone…”
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Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere by Bogomolovas, Julius, Fleming, Jennifer R, Franke, Barbara, Manso, Bruno, Simon, Bernd, Gasch, Alexander, Markovic, Marija, Brunner, Thomas, Knöll, Ralph, Chen, Ju, Labeit, Siegfried, Scheffner, Martin, Peter, Christine, Mayans, Olga

“…Striated muscle undergoes remodelling in response to mechanical and physiological stress, but little is known about the integration of such varied signals in…”
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Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole by Fleming, Jennifer R., Schupfner, Michael, Busch, Florian, Baslé, Arnaud, Ehrmann, Alexander, Sterner, Reinhard, Mayans, Olga

“…Tryptophan synthase (TrpS) is a heterotetrameric αββα enzyme that exhibits complex substrate channeling and allosteric mechanisms and is a model system in…”
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Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism by Zhou, Tiankun, Fleming, Jennifer R., Lange, Stephan, Hessel, Anthony L., Bogomolovas, Julius, Stronczek, Chiara, Grundei, David, Ghassemian, Majid, Biju, Andrea, Börgeson, Emma, Bullard, Belinda, Linke, Wolfgang A., Chen, Ju, Kovermann, Michael, Mayans, Olga

“…[Display omitted] Striated muscle responds to mechanical overload by rapidly up-regulating the expression of the cardiac ankyrin repeat protein, CARP, which…”
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The N2A region of titin has a unique structural configuration by Stronczek, Chiara, Lange, Stephan, Bullard, Belinda, Wolniak, Sebastian, Börgeson, Emma, Mayans, Olga, Fleming, Jennifer R

“…The N2A segment of titin is a main signaling hub in the sarcomeric I-band that recruits various signaling factors and processing enzymes. It has also been…”
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Crystal structure of a GCN5‐related N‐acetyltransferase from Lactobacillus curiae by Fleming, Jennifer R., Hauth, Franziskus, Hartig, Jörg S., Mayans, Olga

“…Members of the GCN5‐related N‐acetyltransferase (GNAT) family are found in all domains of life and are involved in processes ranging from protein synthesis and…”
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CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex by Zhou, Tiankun, Fleming, Jennifer R., Franke, Barbara, Bogomolovas, Julius, Barsukov, Igor, Rigden, Daniel J., Labeit, Siegfried, Mayans, Olga

“…The cardiac ankyrin repeat protein (CARP) is up‐regulated in the myocardium during cardiovascular disease and in response to mechanical or toxic stress…”
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Self‐Assembling Proteins as High‐Performance Substrates for Embryonic Stem Cell Self‐Renewal by Hill, Christopher J., Fleming, Jennifer R., Mousavinejad, Masoumeh, Nicholson, Rachael, Tzokov, Svetomir B., Bullough, Per A., Bogomolovas, Julius, Morgan, Mark R., Mayans, Olga, Murray, Patricia

“…The development of extracellular matrix mimetics that imitate niche stem cell microenvironments and support cell growth for technological applications is…”
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Scalable, Non-denaturing Purification of Phosphoproteins Using Ga3+-IMAC: N2A and M1M2 Titin Components as Study case by Adams, Michael, Fleming, Jennifer R., Riehle, Eva, Zhou, Tiankun, Zacharchenko, Thomas, Markovic, Marija, Mayans, Olga

“…The purification of phosphorylated proteins in a folded state and in large enough quantity for biochemical or biophysical analysis remains a challenging task…”
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Autophosphorylation Is a Mechanism of Inhibition in Twitchin Kinase by Williams, Rhys M., Franke, Barbara, Wilkinson, Mark, Fleming, Jennifer R., Rigden, Daniel J., Benian, Guy M., Eyers, Patrick A., Mayans, Olga

“…Titin-like kinases are muscle-specific kinases that regulate mechanical sensing in the sarcomere. Twitchin kinase (TwcK) is the best-characterized member of…”
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