Search Results - "Fleming, Jason B"

Focal Radiation Therapy Dose Escalation Improves Overall Survival in Locally Advanced Pancreatic Cancer Patients Receiving Induction Chemotherapy and Consolidative Chemoradiation by Krishnan, Sunil, MD, Chadha, Awalpreet S., MD, Suh, Yelin, PhD, Chen, Hsiang-Chun, PhD, Rao, Arvind, PhD, Das, Prajnan, MD, Minsky, Bruce D., MD, Mahmood, Usama, MD, Delclos, Marc E., MD, Sawakuchi, Gabriel O., PhD, Beddar, Sam, PhD, Katz, Matthew H., MD, Fleming, Jason B., MD, Javle, Milind M., MD, Varadhachary, Gauri R., MD, Wolff, Robert A., MD, Crane, Christopher H., MD

“…Purpose To review outcomes of locally advanced pancreatic cancer (LAPC) patients treated with dose-escalated intensity modulated radiation therapy (IMRT) with…”
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Postoperative complications reduce adjuvant chemotherapy use in resectable pancreatic cancer by Merkow, Ryan P, Bilimoria, Karl Y, Tomlinson, James S, Paruch, Jennifer L, Fleming, Jason B, Talamonti, Mark S, Ko, Clifford Y, Bentrem, David J

“…To assess the impact of postoperative complications on the receipt of adjuvant chemotherapy. Randomized trials have demonstrated that adjuvant chemotherapy is…”
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KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma by Ling, Jianhua, Kang, Ya'an, Zhao, Ruiying, Xia, Qianghua, Lee, Dung-Fang, Chang, Zhe, Li, Jin, Peng, Bailu, Fleming, Jason B., Wang, Huamin, Liu, Jinsong, Lemischka, Ihor R., Hung, Mien-Chie, Chiao, Paul J.

“…Constitutive Kras and NF-κB activation is identified as signature alterations in pancreatic ductal adenocarcinoma (PDAC). However, how NF-κB is activated in…”
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IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway by Sun, Longhao, Zhang, Xuebin, Song, Qianqian, Liu, Liang, Forbes, Elizabeth, Tian, Weijun, Zhang, Zhixiang, Kang, Ya'an, Wang, Huamin, Fleming, Jason B., Pasche, Boris C., Zhang, Wei

“…Tumor-associated macrophages (TAMs) represent the M2-like phenotype with potent immunosuppressive activity, and play a pro-tumor role in pancreatic ductal…”
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SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy by Wang, Feng, Xia, Xiaojun, Yang, Chunying, Shen, Jianliang, Mai, Junhua, Kim, Han-Cheon, Kirui, Dickson, Kang, Ya'an, Fleming, Jason B, Koay, Eugene J, Mitra, Sankar, Ferrari, Mauro, Shen, Haifa

“…Understanding the mechanism of radioresistance could help develop strategies to improve therapeutic response of patients with PDAC. The gene is frequently…”
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One Hundred Years After “Carcinoid”: Epidemiology of and Prognostic Factors for Neuroendocrine Tumors in 35,825 Cases in the United States by YAO, James C, HASSAN, Manal, EVANS, Douglas B, PHAN, Alexandria, DAGOHOY, Cecile, LEARY, Colleen, MARES, Jeannette E, ABDALLA, Eddie K, FLEMING, Jason B, VAUTHEY, Jean-Nicolas, RASHID, Asif

“…PURPOSE Neuroendocrine tumors (NETs) are considered rare tumors and can produce a variety of hormones. In this study, we examined the epidemiology of and…”
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ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma by Kim, Michael P, Fleming, Jason B, Wang, Huamin, Abbruzzese, James L, Choi, Woonyoung, Kopetz, Scott, McConkey, David J, Evans, Douglas B, Gallick, Gary E

“…Multiple studies in recent years have identified highly tumorigenic populations of cells that drive tumor formation. These cancer stem cells (CSCs), or…”
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A High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice by Philip, Bincy, Roland, Christina L, Daniluk, Jaroslaw, Liu, Yan, Chatterjee, Deyali, Gomez, Sobeyda B, Ji, Baoan, Huang, Haojie, Wang, Huamin, Fleming, Jason B, Logsdon, Craig D, Cruz–Monserrate, Zobeida

“…Background & Aims Obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC), but it is not clear how obesity contributes to pancreatic…”
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Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis by Kim, Michael P, Li, Xinqun, Deng, Jenying, Zhang, Yun, Dai, Bingbing, Allton, Kendra L, Hughes, Tara G, Siangco, Christian, Augustine, Jithesh J, Kang, Ya'an, McDaniel, Joy M, Xiong, Shunbin, Koay, Eugene J, McAllister, Florencia, Bristow, Christopher A, Heffernan, Timothy P, Maitra, Anirban, Liu, Bin, Barton, Michelle C, Wasylishen, Amanda R, Fleming, Jason B, Lozano, Guillermina

“…Pancreatic ductal adenocarcinoma (PDAC) is almost uniformly fatal and characterized by early metastasis. Oncogenic mutations prevail in 95% of PDAC tumors and…”
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Ninety-day Postoperative Mortality Is a Legitimate Measure of Hepatopancreatobiliary Surgical Quality by Mise, Yoshihiro, Vauthey, Jean-Nicolas, Zimmitti, Giuseppe, Parker, Nathan H, Conrad, Claudius, Aloia, Thomas A, Lee, Jeffrey E, Fleming, Jason B, Katz, Matthew Harold G

“…OBJECTIVE:To investigate the legitimacy of 90-day mortality as a measure of hepatopancreatobiliary quality. BACKGROUND:The 90-day mortality rate has been…”
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Inflammation and Myeloid Cells in Cancer Progression and Metastasis by Deng, Jenying, Fleming, Jason B

“…To date, the most immunotherapy drugs act upon T cell surface proteins to promote tumoricidal T cell activity. However, this approach has to date been…”
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Carboxylesterase 2 as a Determinant of Response to Irinotecan and Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma by Capello, Michela, Lee, Minhee, Wang, Hong, Babel, Ingrid, Katz, Matthew H, Fleming, Jason B, Maitra, Anirban, Wang, Huamin, Tian, Weihua, Taguchi, Ayumu, Hanash, Samir M

“…Serine hydrolases (SHs) are among the largest classes of enzymes in humans and play crucial role in many pathophysiological processes of cancer. We have…”
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma by Aguilera, Kristina Y, Huang, Huocong, Du, Wenting, Hagopian, Moriah M, Wang, Zhen, Hinz, Stefan, Hwang, Tae Hyun, Wang, Huamin, Fleming, Jason B, Castrillon, Diego H, Ren, Xiaomei, Ding, Ke, Brekken, Rolf A

“…The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma (PDA), is rich in fibrillar collagens that facilitate tumor cell…”
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Validation of a Proposed Tumor Regression Grading Scheme for Pancreatic Ductal Adenocarcinoma After Neoadjuvant Therapy as a Prognostic Indicator for Survival by Lee, Sun Mi, Katz, Matthew H.G, Liu, Li, Sundar, Manonmani, Wang, Hua, Varadhachary, Gauri R, Wolff, Robert A, Lee, Jeffrey E, Maitra, Anirban, Fleming, Jason B, Rashid, Asif, Wang, Huamin

“…Neoadjuvant therapy has been increasingly used to treat patients with potentially resectable pancreatic ductal adenocarcinoma (PDAC). Although the College of…”
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Phase II Trial of Cetuximab, Gemcitabine, and Oxaliplatin Followed by Chemoradiation With Cetuximab for Locally Advanced (T4) Pancreatic Adenocarcinoma: Correlation of Smad4(Dpc4) Immunostaining With Pattern of Disease Progression by CRANE, Christopher H, VARADHACHARY, Gauri R, DAS, Prajnan, LEE, Jeffrey E, ABBRUZZESE, James L, WOLFF, Robert A, YORDY, John S, STAERKEL, Gregg A, JAVLE, Milind M, SAFRAN, Howard, HAQUE, Waqar, HOBBS, Bridgett D, KRISHNAN, Sunil, FLEMING, Jason B

“…This phase II trial was designed to assess the efficacy and safety of cetuximab, gemcitabine, and oxaliplatin followed by cetuximab, capecitabine, and…”
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Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice by Gallick, Gary E, Kim, Michael P, Evans, Douglas B, Wang, Huamin, Abbruzzese, James L, Fleming, Jason B

“…For decades, xenografts using well-established human tumor cell lines have been the most commonly used models to study human cancers in mice. More recently,…”
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Value of Neoadjuvant Radiation Therapy in the Management of Pancreatic Adenocarcinoma by Hall, William A, Dawson, Laura A, Hong, Theodore S, Palta, Manisha, Herman, Joseph M, Evans, Douglas B, Tsai, Susan, Ferrone, Cristina R, B Fleming, Jason, Chang, Daniel T, Crane, Christopher, Koong, Albert C, Oar, Andrew, Parikh, Parag, Erickson, Beth, Hoffe, Sarah, Goodman, Karyn A

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Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer by Genovese, Giannicola, Carugo, Alessandro, Tepper, James, Robinson, Frederick Scott, Li, Liren, Svelto, Maria, Nezi, Luigi, Corti, Denise, Minelli, Rosalba, Pettazzoni, Piergiorgio, Gutschner, Tony, Wu, Chia-Chin, Seth, Sahil, Akdemir, Kadir Caner, Leo, Elisabetta, Amin, Samirkumar, Molin, Marco Dal, Ying, Haoqiang, Kwong, Lawrence N., Colla, Simona, Takahashi, Koichi, Ghosh, Papia, Giuliani, Virginia, Muller, Florian, Dey, Prasenjit, Jiang, Shan, Garvey, Jill, Liu, Chang-Gong, Zhang, Jianhua, Heffernan, Timothy P., Toniatti, Carlo, Fleming, Jason B., Goggins, Michael G., Wood, Laura D., Sgambato, Alessandro, Agaimy, Abbas, Maitra, Anirban, Roberts, Charles W. M., Wang, Huamin, Viale, Andrea, DePinho, Ronald A., Draetta, Giulio F., Chin, Lynda

“…Depletion of Smarcb1 activates the Myc network of signalling cascades, increasing protein metabolism and activation of survival pathways allowing highly…”
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Preoperative Therapy and Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma: a 25-Year Single-Institution Experience by Cloyd, Jordan M., Katz, Matthew H. G., Prakash, Laura, Varadhachary, Gauri R., Wolff, Robert A., Shroff, Rachna T., Javle, Milind, Fogelman, David, Overman, Michael, Crane, Christopher H., Koay, Eugene J., Das, Prajnan, Krishnan, Sunil, Minsky, Bruce D., Lee, Jeffrey H., Bhutani, Manoop S., Weston, Brian, Ross, William, Bhosale, Priya, Tamm, Eric P., Wang, Huamin, Maitra, Anirban, Kim, Michael P., Aloia, Thomas A., Vauthey, Jean-Nicholas, Fleming, Jason B., Abbruzzese, James L., Pisters, Peter W. T., Evans, Douglas B., Lee, Jeffrey E.

“…Background The purpose of this study was to evaluate a single-institution experience with delivery of preoperative therapy to patients with pancreatic ductal…”
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DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis by Deng, Jenying, Kang, Yaan, Cheng, Chien-Chia, Li, Xinqun, Dai, Bingbing, Katz, Matthew H, Men, Taoyan, Kim, Michael P, Koay, Eugene A, Huang, Huocong, Brekken, Rolf A, Fleming, Jason B

“…Pancreatic ductal adenocarcinoma (PDAC) tumors are characterized by a desmoplastic reaction resulting in dense deposition of collagen that is known to promote…”
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