Search Results - "Fleming, Alicia K"

Protein kinase D1 - A targetable mediator of pancreatic cancer development by Fleming Martinez, Alicia K, Storz, Peter

“…Members of the Protein kinase D (PKD) kinase family each play important cell-specific roles in the regulation of normal pancreas functions. In pancreatic…”
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Inflammatory and alternatively activated macrophages independently induce metaplasia but cooperatively drive pancreatic precancerous lesion growth by Liou, Geou-Yarh, Fleming Martinez, Alicia K., Döppler, Heike R., Bastea, Ligia I., Storz, Peter

“…The innate immune system has a key role in pancreatic cancer initiation, but the specific contribution of different macrophage populations is still…”
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Ym1+ macrophages orchestrate fibrosis, lesion growth, and progression during development of murine pancreatic cancer by Fleming Martinez, Alicia K., Döppler, Heike R., Bastea, Ligia I., Edenfield, Brandy H., Liou, Geou-Yarh, Storz, Peter

“…Desmoplasia around pancreatic lesions is a barrier for immune cells and a hallmark of developing and established pancreatic cancer. However, the contribution…”
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Legumain is activated in macrophages during pancreatitis by Edgington-Mitchell, Laura E, Wartmann, Thomas, Fleming, Alicia K, Gocheva, Vasilena, van der Linden, Wouter A, Withana, Nimali P, Verdoes, Martijn, Aurelio, Luigi, Edgington-Mitchell, Daniel, Lieu, TinaMarie, Parker, Belinda S, Graham, Bim, Reinheckel, Thomas, Furness, John B, Joyce, Johanna A, Storz, Peter, Halangk, Walter, Bogyo, Matthew, Bunnett, Nigel W

“…Pancreatitis is an inflammatory disease of the pancreas characterized by dysregulated activity of digestive enzymes, necrosis, immune infiltration, and pain…”
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Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells by Fleming Martinez, Alicia K., Döppler, Heike R., Bastea, Ligia I., Edenfield, Brandy, Patel, Tushar, Leitges, Michael, Liou, Geou-Yarh, Storz, Peter

“…Doublecortin-like kinase 1 (DCLK1)-positive pancreatic cancer stem cells develop at a precancerous stage and may contribute to the lack of efficacy of…”
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Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture by Fleming Martinez, Alicia K, Storz, Peter

“…The differentiation of acinar cells to ductal cells during pancreatitis and in the early development of pancreatic cancer is a key process that requires…”
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Protein kinase C isoforms in the normal pancreas and in pancreatic disease by Fleming, Alicia K., Storz, Peter

“…Protein Kinase C isoforms have been implicated in regulating multiple processes within the healthy pancreas. Moreover, their dysregulation contributes to all…”
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Pomalidomide Alters Pancreatic Macrophage Populations to Generate an Immune-Responsive Environment at Precancerous and Cancerous Lesions by Bastea, Ligia I, Liou, Geou-Yarh, Pandey, Veethika, Fleming, Alicia K, von Roemeling, Christina A, Doeppler, Heike, Li, Zhimin, Qiu, Yushi, Edenfield, Brandy, Copland, John A, Tun, Han W, Storz, Peter

“…During development of pancreatic cancer, alternatively activated macrophages contribute to fibrogenesis, pancreatic intraepithelial neoplasia (PanIN) lesion…”
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Abstract 4779: MnSOD mimetic mitoquinone mesylate (MitoQ) increases DCLK1+pancreatic cancer stem cells by Perera, Jeffrey Mario, Martinez, Alicia K. Fleming, Storz, Peter

“…Mitochondrially-generated reactive oxygen species (mROS) have been shown to induce acinar-to-ductal metaplasia (ADM). ADM, in presence of an oncogenic KRAS…”
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Abstract 922: Knockout of Sod2 accelerates formation of pancreatic atypical flat lesions which are a direct precursor to pancreatic ductal adenocarcinoma (PDA) by Martinez, Alicia K. Fleming, Edenfield, Brandy H., Esposito, Irene, Storz, Peter

“…Manganese superoxide dismutase (MnSOD) is an important reactive oxygen species (ROS) scavenger which has largely been studied in pancreatic cancer cell lines,…”
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Abstract 4775: Knockout of Sod2 accelerates KrasG12D -driven formation of pancreatic cancerous lesions by Fleming Martinez, Alicia K., Edenfield, Brandy H., Esposito, Irene, Storz, Peter

“…Recent studies demonstrate that mitochondrially-generated reactive oxygen species (ROS) downstream of oncogenic KRAS drive acinar-to-ductal metaplasia (ADM), a…”
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