Search Results - "Fleeman, Renee M"

Polyproline Peptide Aggregation with Klebsiella pneumoniae Extracellular Polysaccharides Exposes Biofilm Associated Bacteria by Fleeman, Renee M, Davies, Bryan W

“…Klebsiella pneumoniae produces a thick capsule layer composed of extracellular polysaccharides protecting the bacterial cells from clearance by innate host…”
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Exposing the Unique Connection between Metabolism and Virulence in Staphylococcus aureus by Weiss, Andy, Fleeman, Renee M, Shaw, Lindsey N

“…In this issue of Cell Chemical Biology, Choby et al. (2016) use a small molecule inhibitor active against fermenting S. aureus to unravel a unique connection…”
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Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens by Fleeman, Renee M, Debevec, Ginamarie, Antonen, Kirsten, Adams, Jessie L, Santos, Radleigh G, Welmaker, Gregory S, Houghten, Richard A, Giulianotti, Marc A, Shaw, Lindsey N

“…We have previously reported the use of combinatorial chemistry to identify broad-spectrum antibacterial agents. Herein, we extend our analysis of this…”
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Synthetic antibacterial discovery of symbah-1, a macrocyclic β-hairpin peptide antibiotic by Randall, Justin R., Davidson, Gillian, Fleeman, Renee M., Acosta, Santos A., Riddington, Ian M., Cole, T. Jeffrey, DuPai, Cory D., Davies, Bryan W.

“…The rapid development and spread of antibiotic resistance necessitate the development of novel strategies for antibiotic discovery. Symbah-1, a synthetic…”
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Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae by Fleeman, Renee M., Macias, Luis A., Brodbelt, Jennifer S., Davies, Bryan W.

“…The extracellular polysaccharide capsule of Klebsiella pneumoniae resists penetration by antimicrobials and protects the bacteria from the innate immune…”
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Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa by von Salm, Jacqueline L, Witowski, Christopher G, Fleeman, Renee M, McClintock, James B, Amsler, Charles D, Shaw, Lindsey N, Baker, Bill J

“…A new rearranged spongian diterpene, darwinolide, has been isolated from the Antarctic Dendroceratid sponge Dendrilla membranosa. Characterized on the basis of…”
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Investigating Klebsiella pneumoniae biofilm preservation for scanning electron microscopy by Fleeman, Renee M, Mikesh, Michelle, Davies, Bryan W

“…biofilm formation is associated with chronic and relapsing infections. Scanning electron microscopy (SEM) is a powerful tool for characterizing biofilm…”
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Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities by Bionda, Nina, Fleeman, Renee M., de la Fuente-Núñez, César, Rodriguez, Maria C., Reffuveille, Fany, Shaw, Lindsey N., Pastar, Irena, Davis, Stephen C., Hancock, Robert E.W., Cudic, Predrag

“…Treating bacterial infections can be difficult due to innate or acquired resistance mechanisms, and the formation of biofilms. Cyclic lipopeptides derived from…”
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Effect of Ester to Amide or N-Methylamide Substitution on Bacterial Membrane Depolarization and Antibacterial Activity of Novel Cyclic Lipopeptides by Bionda, Nina, Fleeman, Renee M., Shaw, Lindsey N., Cudic, Predrag

“…Cyclic lipopeptides derived from the fusaricidin/LI‐F family of naturally occurring antibiotics represent particularly attractive candidates for the…”
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Polyproline peptide targets Klebsiella pneumoniae polysaccharides to collapse biofilms by De los Santos, Laura, Beckman, Robert L., DeBarro, Christina, Keener, James E., Torres, Marcelo D.T., Fuente-Nunez, Cesar de la, Brodbelt, Jennifer S., Fleeman, Renee M.

“…Hypervirulent Klebsiella pneumoniae is known for its increased extracellular polysaccharide production. Biofilm matrices of hypervirulent K. pneumoniae have…”
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Effect of Ester to Amide or N-methyl Amide Substitution on Bacterial Membrane Depolarization and Antibacterial Activity of Novel Cyclic Lipopeptides by Bionda, Nina, Fleeman, Renee M., Shaw, Lindsey N., Cudic, Predrag

“…Cyclic lipopeptides derived from the fusaricidin/LI-F family of naturally occurring antibiotics represent particularly attractive candidates for the…”
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