Search Results - "Fleeman, Renee"

Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae by Fleeman, Renee M., Macias, Luis A., Brodbelt, Jennifer S., Davies, Bryan W.

“…The extracellular polysaccharide capsule of Klebsiella pneumoniae resists penetration by antimicrobials and protects the bacteria from the innate immune…”
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Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities by Bionda, Nina, Fleeman, Renee M., de la Fuente-Núñez, César, Rodriguez, Maria C., Reffuveille, Fany, Shaw, Lindsey N., Pastar, Irena, Davis, Stephen C., Hancock, Robert E.W., Cudic, Predrag

“…Treating bacterial infections can be difficult due to innate or acquired resistance mechanisms, and the formation of biofilms. Cyclic lipopeptides derived from…”
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Polyproline Peptide Aggregation with Klebsiella pneumoniae Extracellular Polysaccharides Exposes Biofilm Associated Bacteria by Fleeman, Renee M, Davies, Bryan W

“…Klebsiella pneumoniae produces a thick capsule layer composed of extracellular polysaccharides protecting the bacterial cells from clearance by innate host…”
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Exposing the Unique Connection between Metabolism and Virulence in Staphylococcus aureus by Weiss, Andy, Fleeman, Renee M, Shaw, Lindsey N

“…In this issue of Cell Chemical Biology, Choby et al. (2016) use a small molecule inhibitor active against fermenting S. aureus to unravel a unique connection…”
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Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens by Fleeman, Renee M, Debevec, Ginamarie, Antonen, Kirsten, Adams, Jessie L, Santos, Radleigh G, Welmaker, Gregory S, Houghten, Richard A, Giulianotti, Marc A, Shaw, Lindsey N

“…We have previously reported the use of combinatorial chemistry to identify broad-spectrum antibacterial agents. Herein, we extend our analysis of this…”
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Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa by von Salm, Jacqueline L, Witowski, Christopher G, Fleeman, Renee M, McClintock, James B, Amsler, Charles D, Shaw, Lindsey N, Baker, Bill J

“…A new rearranged spongian diterpene, darwinolide, has been isolated from the Antarctic Dendroceratid sponge Dendrilla membranosa. Characterized on the basis of…”
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Investigating Klebsiella pneumoniae biofilm preservation for scanning electron microscopy by Fleeman, Renee M, Mikesh, Michelle, Davies, Bryan W

“…biofilm formation is associated with chronic and relapsing infections. Scanning electron microscopy (SEM) is a powerful tool for characterizing biofilm…”
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Synthetic antibacterial discovery of symbah-1, a macrocyclic β-hairpin peptide antibiotic by Randall, Justin R., Davidson, Gillian, Fleeman, Renee M., Acosta, Santos A., Riddington, Ian M., Cole, T. Jeffrey, DuPai, Cory D., Davies, Bryan W.

“…The rapid development and spread of antibiotic resistance necessitate the development of novel strategies for antibiotic discovery. Symbah-1, a synthetic…”
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Klebsiella pneumoniae DedA family proteins have redundant roles in divalent cation homeostasis and resistance to phagocytosis by Tiwari, Vijay, Sharma, Amit, Braga, Reygan, Garcia, Emily, Appiah, Ridhwana, Fleeman, Renee, Abuaita, Basel H, Patrauchan, Marianna, Doerrler, William T

“…The DedA superfamily is a highly conserved family of membrane proteins. Deletion of and , encoding related DedA family proteins, results in sensitivity to…”
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Effect of Ester to Amide or N-Methylamide Substitution on Bacterial Membrane Depolarization and Antibacterial Activity of Novel Cyclic Lipopeptides by Bionda, Nina, Fleeman, Renee M., Shaw, Lindsey N., Cudic, Predrag

“…Cyclic lipopeptides derived from the fusaricidin/LI‐F family of naturally occurring antibiotics represent particularly attractive candidates for the…”
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Polyproline peptide targets Klebsiella pneumoniae polysaccharides to collapse biofilms by De los Santos, Laura, Beckman, Robert L., DeBarro, Christina, Keener, James E., Torres, Marcelo D.T., Fuente-Nunez, Cesar de la, Brodbelt, Jennifer S., Fleeman, Renee M.

“…Hypervirulent Klebsiella pneumoniae is known for its increased extracellular polysaccharide production. Biofilm matrices of hypervirulent K. pneumoniae have…”
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Exploitation of Mangrove Endophytic Fungi for Infectious Disease Drug Discovery by Demers, Danielle H, Knestrick, Matthew A, Fleeman, Renee, Tawfik, Rahmy, Azhari, Ala, Souza, Ashley, Vesely, Brian, Netherton, Mandy, Gupta, Rashmi, Colon, Beatrice L, Rice, Christopher A, Rodríguez-Pérez, Mario A, Rohde, Kyle H, Kyle, Dennis E, Shaw, Lindsey N, Baker, Bill J

“…There is an acute need for new and effective agents to treat infectious diseases. We conducted a screening program to assess the potential of mangrove-derived…”
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Antibacterial activity of a series of N2,N4-disubstituted quinazoline-2,4-diamines by Van Horn, Kurt S, Burda, Whittney N, Fleeman, Renee, Shaw, Lindsey N, Manetsch, Roman

“…A series of N(2),N(4)-disubstituted quinazoline-2,4-diamines has been synthesized and tested against multidrug resistant Staphylococcus aureus. A…”
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Repurposing Inhibitors of Phosphoinositide 3-kinase as Adjuvant Therapeutics for Bacterial Infections by Fleeman, Renee

“…The rise in antimicrobial resistance and the decline in new antibiotics has created a great need for novel approaches to treat drug resistant bacterial…”
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Antibacterial Activity of a Series of N 2,N 4‑Disubstituted Quinazoline-2,4-diamines by Van Horn, Kurt S, Burda, Whittney N, Fleeman, Renee, Shaw, Lindsey N, Manetsch, Roman

“…A series of N 2,N 4-disubstituted quinazoline-2,4-diamines has been synthesized and tested against multidrug resistant Staphylococcus aureus. A…”
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Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens by Fleeman, Renee, LaVoi, Travis M, Santos, Radleigh G, Morales, Angela, Nefzi, Adel, Welmaker, Gregory S, Medina-Franco, José L, Giulianotti, Marc A, Houghten, Richard A, Shaw, Lindsey N

“…Mixture based synthetic combinatorial libraries offer a tremendous enhancement for the rate of drug discovery, allowing the activity of millions of compounds…”
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Identification of 5,6-dihydroimidazo[2,1-b]thiazoles as a new class of antimicrobial agents by Li, Yangmei, Bionda, Nina, Fleeman, Renee, Wang, Hongjie, Ozawa, Akihiko, Houghten, Richard A., Shaw, Lindsey

“…[Display omitted] In an effort to develop novel antimicrobial agents against drug-resistant bacterial infections, 5,6-dihydroimidazo[2,1-b]thiazole compounds…”
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Characterizing the Antimicrobial Activity of N2,N4-Disubstituted Quinazoline-2,4-Diamines toward Multidrug-Resistant Acinetobacter baumannii by Fleeman, Renee, Van Horn, Kurt S, Barber, Megan M, Burda, Whittney N, Flanigan, David L, Manetsch, Roman, Shaw, Lindsey N

“…We previously reported a series of N2,N4-disubstituted quinazoline-2,4-diamines as dihydrofolate reductase inhibitors with potent in vitro and in vivo…”
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The “PepSAVI-MS” Pipeline for Natural Product Bioactive Peptide Discovery by Kirkpatrick, Christine L, Broberg, Christopher A, McCool, Elijah N, Lee, Woo Jean, Chao, Alex, McConnell, Evan W, Pritchard, David A, Hebert, Michael, Fleeman, Renee, Adams, Jessie, Jamil, Amer, Madera, Laurence, Strömstedt, Adam A, Göransson, Ulf, Liu, Yufeng, Hoskin, David W, Shaw, Lindsey N, Hicks, Leslie M

“…The recent increase in extensively drug-resistant bacterial pathogens and the associated increase of morbidity and mortality demonstrate the immediate need for…”
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Discovering Antibacterial and Anti-Resistance Agents Targeting Multi-Drug Resistant ESKAPE Pathogens by Fleeman, Renee

“…Antibiotic resistance has been a developing problem for mankind in recent decades and multi-drug resistant bacteria are now encountered that are resistant to…”
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