Search Results - "Flechtner, Jessica Baker"

TH17-Based Vaccine Design for Prevention of Streptococcus pneumoniae Colonization by Moffitt, Kristin L., Gierahn, Todd M., Lu, Ying-jie, Gouveia, Paulo, Alderson, Mark, Flechtner, Jessica Baker, Higgins, Darren E., Malley, Richard

“…Streptococcus pneumoniae is a leading cause of mortality in young children. While successful conjugate polysaccharide vaccines exist, a less expensive…”
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Expanded ATLAS™-identified neoantigen-specific peripheral T cells (NPTs) demonstrate considerable neoantigen breadth, polyfunctionality, and effector function by Perry, James R, Reuter, Mercay, DeVault, Victoria L, Li, Adrienne, Zope, Harshal, DeOliveira, Daniel B, Khare, Pranay D, Jain, Manish, Winstead, Colleen J, Lam, Hubert, Flechtner, Jessica Baker

“…Abstract Adoptive T cell therapy using ex vivo expanded autologous tumor-infiltrating lymphocytes (TIL) has resulted in notable tumor regression across…”
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T(H)17-based vaccine design for prevention of Streptococcus pneumoniae colonization by Moffitt, Kristin L, Gierahn, Todd M, Lu, Ying-jie, Gouveia, Paulo, Alderson, Mark, Flechtner, Jessica Baker, Higgins, Darren E, Malley, Richard

“…Streptococcus pneumoniae is a leading cause of mortality in young children. While successful conjugate polysaccharide vaccines exist, a less expensive…”
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Evolution of rational vaccine designs for genital herpes immunotherapy by Kaufmann, Johanna Katharina, Flechtner, Jessica Baker

“…•Early genital herpes immunotherapy aimed at inducing neutralizing antibodies.•Herpes-specific T cell responses may be as important as antibody for disease…”
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An Empirical Antigen Selection Method Identifies Neoantigens That Either Elicit Broad Antitumor T-cell Responses or Drive Tumor Growth by Lam, Hubert, McNeil, Lisa K, Starobinets, Hanna, DeVault, Victoria L, Cohen, Roger B, Twardowski, Przemyslaw, Johnson, Melissa L, Gillison, Maura L, Stein, Mark N, Vaishampayan, Ulka N, DeCillis, Arthur P, Foti, James J, Vemulapalli, Vijetha, Tjon, Emily, Ferber, Kyle, DeOliveira, Daniel B, Broom, Wendy, Agnihotri, Parul, Jaffee, Elizabeth M, Wong, Kwok-Kin, Drake, Charles G, Carroll, Pamela M, Davis, Thomas A, Flechtner, Jessica Baker

“…Neoantigens are critical targets of antitumor T-cell responses. The ATLAS bioassay was developed to identify neoantigens empirically by expressing each unique…”
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Immune responses elicited by the GEN-003 candidate HSV-2 therapeutic vaccine in a randomized controlled dose-ranging phase 1/2a trial by Flechtner, Jessica Baker, Long, Deborah, Larson, Shane, Clemens, Veronica, Baccari, Amy, Kien, Lena, Chan, Jason, Skoberne, Mojca, Brudner, Matthew, Hetherington, Seth

“…Highlights • Cellular and humoral responses were boosted in GEN-003 vaccinated HSV-2 seropositive subjects. • Matrix-M2 adjuvant potentiated the immune…”
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Toll-like receptor 2-dependent protection against pneumococcal carriage by immunization with lipidated pneumococcal proteins by Moffitt, Kristin, Skoberne, Mojca, Howard, Angela, Gavrilescu, L Cristina, Gierahn, Todd, Munzer, Scott, Dixit, Bharat, Giannasca, Paul, Flechtner, Jessica Baker, Malley, Richard

“…Infections with Streptococcus pneumoniae cause substantial morbidity and mortality, particularly in children in developing nations. Polysaccharide-conjugate…”
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Proteins as T cell antigens: Methods for high-throughput identification by Grubaugh, Daniel, Flechtner, Jessica Baker, Higgins, Darren E

“…Highlights • Cellular immunity is a necessary component for vaccines directed to some pathogens. • Full-protein antigens rather than peptide epitopes ensure…”
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High-throughput proteomic screening identifies Chlamydia trachomatis antigens that are capable of eliciting T cell and antibody responses that provide protection against vaginal challenge by Picard, Michele D, Cohane, Kenya Prince, Gierahn, Todd M, Higgins, Darren E, Flechtner, Jessica Baker

“…Highlights ► Chlamydia proteomic screen yielded T cell antigens for vaccine development. ► Screening of peripheral T cells can identify T cell antigens…”
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Abstract 2745: The PLANET manufacturing process reproducibly generates high-quality neoantigen-targeted peripheral T cells (NPTs) for adoptive T cell therapy in the TiTAN clinical trial by Zope, Harshal, Nande, Rounak, Jain, Manish, Hubbard, Charley, Dowal, Louisa, Foti, James, Loizeaux, James, Cabral, Crystal, DeOliveira, Daniel B., Yang, Guohan, Reuter, Mercay, Flechtner, Jessica Baker, Stapleton, Raymond

“…Abstract Background: Neoantigen (neoAg)-specific T cells can be found in the peripheral blood of patients with solid tumors, and the infiltration of fresh,…”
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Resolution of Chlamydia trachomatis Infection Is Associated with a Distinct T Cell Response Profile by Picard, Michele D, Bodmer, Jean-Luc, Gierahn, Todd M, Lee, Alexander, Price, Jessica, Cohane, Kenya, Clemens, Veronica, DeVault, Victoria L, Gurok, Galina, Kohberger, Robert, Higgins, Darren E, Siber, George R, Flechtner, Jessica Baker, Geisler, William M

“…Chlamydia trachomatis is the causative agent of the most frequently reported bacterial sexually transmitted infection, the total burden of which is…”
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High-throughput proteomic screening identifiesChlamydia trachomatisantigens that are capable of eliciting T cell and antibody responses that provide protection against vaginal challenge by Picard, Michele D, Cohane, Kenya Prince, Gierahn, Todd M, Higgins, Darren E, Flechtner, Jessica Baker

“…Highlights *Chlamydiaproteomic screen yielded T cell antigens for vaccine development. * Screening of peripheral T cells can identify T cell antigens…”
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