Search Results - "Flechsig, E"

A Quantitative, Highly Sensitive Cell-Based Infectivity Assay for Mouse Scrapie Prions by P. -C. Klöhn, Stoltze, L., Flechsig, E., Enari, M., Weissmann, C.

“…Prions are usually quantified by bioassays based on intracerebral inoculation of mice that are slow, imprecise, and costly. We have isolated neuroblastoma N2a…”
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PrP knock-out and PrP transgenic mice in prion research by Weissmann, C, Flechsig, E

“…Spongiform encephalopathies such as scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle or Creutzfeldt-Jacob disease (CJD) and…”
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Scrapie Prion Protein Accumulation by Scrapie-Infected Neuroblastoma Cells Abrogated by Exposure to a Prion Protein Antibody by Enari, Masato, Flechsig, Eckhard, Weissmann, Charles

“…Exposure of susceptible neuroblastoma N2a cells to mouse scrapie prions leads to infection, as evidenced by the continued presence of the scrapie form of the…”
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Transmission of Prions by Weissmann, C., Enari, M., P.-C. Klöhn, Rossi, D., Flechsig, E.

“…The "protein only" hypothesis states that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host…”
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The role of PrP in health and disease by Flechsig, E, Weissmann, C

“…Transmissible spongiform encephalopathies (TSEs) such as scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle or Creutzfeldt-Jacob disease (CJD)…”
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Transmission of scrapie by steel-surface-bound prions by Flechsig, E, Hegyi, I, Enari, M, Schwarz, P, Collinge, J, Weissmann, C

“…Prions are unusually resistant to conventional disinfection procedures. An electrode used intracerebrally on a Creutzfeldt-Jakob disease (CJD) patient…”
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Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia by Weissmann, Charles, Flechsig, Eckhard, Hegyi, Ivan, Leimeroth, Rainer, Zuniga, Armando, Rossi, Daniela, Cozzio, Antonio, Schwarz, Petra, Rülicke, Thomas, Götz, Jürgen, Aguzzi, Adriano

“…PrP knockout mice with disruption of only the PrP‐encoding region (Zürich I‐type) remain healthy, whereas mice with deletions extending upstream of the…”
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Transmission of Prions by Weissmann, C., Enari, M., Klöhn, P-C., Rossi, D., Flechsig, E.

“…The “protein only” hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host…”
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Infectivity of scrapie prions bound to a stainless steel surface by Zobeley, E, Flechsig, E, Cozzio, A, Enari, M, Weissmann, C

“…The transmissible agent of Creutzfeldt-Jakob disease (CJD) is not readily destroyed by conventional sterilization and transmissions by surgical instruments…”
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Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain by Rossi, Daniela, Cozzio, Antonio, Flechsig, Eckhard, Klein, Michael A., Rülicke, Thomas, Aguzzi, Adriano, Weissmann, Charles

“…PrP knockout mice in which only the open reading frame was disrupted (‘Zürich I’) remained healthy. However, more extensive deletions resulted in ataxia,…”
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The Tyrosine Kinase Inhibitor STI571 Induces Cellular Clearance of PrPSc in Prion-infected Cells by Ertmer, Alexa, Gilch, Sabine, Yun, Seong-Wook, Flechsig, Eckhard, Klebl, Bert, Stein-Gerlach, Matthias, Klein, Michael A, Schätzl, Hermann M

“…The conversion of the cellular prion protein (PrP c ) into pathologic PrP Sc and the accumulation of aggregated PrP Sc are hallmarks of prion diseases. A…”
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Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice by Flechsig, E, Shmerling, D, Hegyi, I, Raeber, A J, Fischer, M, Cozzio, A, von Mering, C, Aguzzi, A, Weissmann, C

“…Mice devoid of PrP are resistant to scrapie and fail to replicate the agent. Introduction of transgenes expressing PrP into such mice restores susceptibility…”
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Expression of Amino-Terminally Truncated PrP in the Mouse Leading to Ataxia and Specific Cerebellar Lesions by Shmerling, Doron, Hegyi, Ivan, Fischer, Marek, Blättler, Thomas, Brandner, Sebastian, Götz, Jürgen, Rülicke, Thomas, Flechsig, Eckhard, Cozzio, Antonio, von Mering, Christian, Hangartner, Christoph, Aguzzi, Adriano, Weissmann, Charles

“…The physiological role of prion protein (PrP) remains unknown. Mice devoid of PrP develop normally but are resistant to scrapie; introduction of a PrP…”
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An enzyme-detergent method for effective prion decontamination of surgical steel by Jackson, Graham S, McKintosh, Edward, Flechsig, Eckhard, Prodromidou, Kanella, Hirsch, Petra, Linehan, Jackie, Brandner, Sebastian, Clarke, Anthony R, Weissmann, Charles, Collinge, John

“…MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK Correspondence…”
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crucial role for B cells in neuroinvasive scrapie by Klein, M.A, Frigg, R, Flechsig, E, Raeber, A.J, Kalinke, U, Bluethmann, H, Bootz, F, Suter, M, Zinkernagel, R.M, Agussi, A

“…Although prion proteins are most efficiently propagated through intracerebral inoculation, peripheral administration has caused the diseases kuru, iatrogenic…”
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PrP expression in B lymphocytes is not required for prion neuroinvasion by Aguzzi, Adriano, Klein, Michael A, Frigg, Rico, Raeber, Alex J, Flechsig, Eckhard, Hegyi, Ivan, Zinkernagel, Rolf M, Weissmann, Charles

“…Prion diseases are typically initiated by infection of peripheral sites, as in the case of bovine spongiform encephalopathy, new variant Creutzfeldt-Jakob…”
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PrP knock-out and PrP transgenic mice in prion research: Prions for physicians by WEISSMANN, C, FLECHSIG, E

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The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery by Yun, Seong-Wook, Ertmer, Alexa, Flechsig, Eckhard, Gilch, Sabine, Riederer, Peter, Gerlach, Manfred, Schätzl, Hermann M, Klein, Michael A

“…Prion diseases are fatal neurodegenerative disorders with no effective therapy. A hallmark of prion disease is the conversion of the normal cellular form of…”
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Adenoviral and Adeno-Associated Viral Transfer of Genes to the Peripheral Nervous System by Glatzel, Markus, Flechsig, Eckhard, Navarro, Beatriz, Klein, Michael A., Paterna, Jean C., Büeler, Hansruedi, Aguzzi, Adriano

“…Targeted expression of foreign genes to the peripheral nervous system is interesting for many applications, including gene therapy of neuromuscular diseases,…”
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Similar Turnover and Shedding of the Cellular Prion Protein in Primary Lymphoid and Neuronal Cells by Parizek, P, Roeckl, C, Weber, J, Flechsig, E, Aguzzi, A, Raeber, A J

“…The cellular prion protein (PrP C ) is essential for pathogenesis and transmission of prion diseases. Although prion replication in the brain is accompanied by…”
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