Search Results - "Flavell, D"

Therapy of human T-cell acute lymphoblastic leukaemia with a combination of anti-CD7 and anti-CD38-SAPORIN immunotoxins is significantly better than therapy with each individual immunotoxin by FLAVELL, D. J, BOEHM, D. A, NOSS, A, WARNES, S. L, FLAVELL, S. U

“…Severe combined immunodeficient (SCID) mice injected i.v. with the human T-ALL cell line CCRF CEM (SCID-CEM mice) develop within 50 days life-threatening…”
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Characterization of the Human PPARα Promoter: Identification of a Functional Nuclear Receptor Response Element by Pineda Torra, Inés, Jamshidi, Yalda, Flavell, David M, Fruchart, Jean-Charles, Staels, Bart

“…PPARα is a nuclear receptor that controls lipid and glucose metabolism and exerts antiinflammatory activities. The factors regulating human PPARα (hPPARα) gene…”
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Saporin immunotoxins by Flavell, D J

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Variants in the APOC3 promoter insulin responsive element modulate insulin secretion and lipids in middle-aged men by Waterworth, D.M., Talmud, P.J., Luan, J., Flavell, D.M., Byrne, C.D., Humphries, S.E., Wareham, N.J.

“…Variation in the insulin responsive element (IRE) of the APOC3 promoter has been shown to be associated with insulin and glucose concentrations after an oral…”
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Genetic determinants of the response to bezafibrate treatment in the lower extremity arterial disease event reduction (LEADER) trial by Jamshidi, Y., Flavell, D.M., Hawe, E., MacCallum, P.K., Meade, T.W., Humphries, S.E.

“…Genetic determinants of baseline levels and the fall in plasma triglyceride and fibrinogen levels in response to bezafibrate treatment were examined in 853 men…”
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PPARα gene variation and physical performance in Russian athletes by Ahmetov, Ildus I, Mozhayskaya, Irina A, Flavell, David M, Astratenkova, Irina V, Komkova, Antonina I, Lyubaeva, Ekaterina V, Tarakin, Pavel P, Shenkman, Boris S, Vdovina, Anastasia B, Netreba, Aleksei I, Popov, Daniil V, Vinogradova, Olga L, Montgomery, Hugh E, Rogozkin, Viktor A

“…Peroxisome proliferator-activated receptor a (PPAR alpha ) regulates genes responsible for skeletal and heart muscle fatty acid oxidation. Previous studies…”
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Determining Drought on California's Mediterranean-Type Rangelands: The Noninsured Crop Disaster Assistance Program by George, M. R, Larsen, R. E, McDougald, N. M, Vaughn, C. E, Flavell, D. K, Dudley, D. M, Frost, W. E, Striby, K. D, Forero, L. C

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Variation in the PPARα gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects by Flavell, D. M., Torra, I. Pineda, Jamshidi, Y., Evans, D., Diamond, J. R., Elkeles, R. S., Bujac, S. R., Miller, G., Talmud, P. J., Staels, B., Humphries, S. E.

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Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH‐releasing factor neurons by Flavell, D. M., Wells, T., Wells, S. E., Carmignac, D. F., Thomas, G. B., Robinson, I. C.

“…Expression of human growth hormone (hGH) was targeted to growth hormone‐releasing (GRF) neurons in the hypothalamus of transgenic rats. This induced dominant…”
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High-Frequency Mutagenesis of Human Cells and Characterization of a Mutant Unresponsive to both α and γ Interferons by McKendry, R, John, J, Flavell, D, Müller, M, Kerr, I M, Stark, G R

“…2fTGH is a human cell line containing the selectable marker guanine phosphoribosyltransferase regulated by α interferon (IFN-α). Two IFN-α-unresponsive mutants…”
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Anti-CD7 antibody and immunotoxin treatment of human CD7 T-cell leukaemia is significantly less effective in NOD/LtSz-scid mice than in CB.17 scid mice by FLAVELL, D. J, WARNES, S. L, NOSS, A. L, FLAVELL, S. U

“…Groups of 8 to ten SCID (CB.17 scid/scid) or NOD/SCID (NOD/LtSz- scid/scid) mice were injected i.v. with two million human HSB-2 T-ALL cells on day 1…”
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Systemic therapy with 3BIT, a triple combination cocktail of anti-CD19, -CD22, and -CD38-saporin immunotoxins, is curative of human B-cell lymphoma in severe combined immunodeficient mice by FLAVELL, D. J, NOSS, A, PULFORD, K. A. F, LING, N, FLAVELL, S. U

“…We demonstrate in these preclinical studies that all severe combined immunodeficient mice injected with the human B-cell lymphoma cell line Ramos are cured…”
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Preclinical studies with the anti-CD19-saporin immunotoxin BU12-SAPORIN for the treatment of human-B-cell tumours by FLAVELL, D. J, FLAVELL, S. U, BOEHM, D. A, EMERY, L, NOSS, A, LING, N. R, RICHARDSON, P. R, HARDIE, D, WRIGHT, D. H

“…The immunotoxin BU12-SAPORIN was constructed by covalently coupling the single-chain ribosome-inactivating protein saporin to the anti-CD19 monoclonal antibody…”
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Identification of tissue histiocytes on paraffin sections by a new monoclonal antibody by Flavell, DJ, Jones, DB, Wright, DH

“…A mouse monoclonal antibody (MAC 387) with specificity for monocytes and tissue histiocytes was produced by immunization of a BALB/c mouse with peripheral…”
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Host-mediated antibody-dependent cellular cytotoxicity contributes to the in vivo therapeutic efficacy of an anti-CD7-saporin immunotoxin in a severe combined immunodeficient mouse model of human T-cell acute lymphoblastic leukemia by FLAVELL, D. J, WARNES, S, NOSS, A, FLAVELL, S. U

“…We have investigated the anti-leukemia effect that is exerted by the murine anti-CD7 antibody HB2 in a severe combined immunodeficient (SCID) mouse model of…”
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Comparison of immunotoxins bearing a single saporin molecule with multiple toxin conjugates by Flavell, D J, Flavell, S U

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Paraplegia secondary to Burkholderia pseudomallei myelitis: A case report by Haran, Mark J., Jenney, Adam W., Keenan, J., Flavell, Howard D., Anstey, Nicholas M., Currie, Bart J.

“…Haran MJ, Jenney AW, Keenan RJ, Flavell HD, Anstey NM, Currie BJ. Paraplegia secondary to Burkholderia pseudomallei myelitis: a case report. Arch Phys Med…”
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Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons by JOHN, J, MCKENDRY, R, PELLEGRINI, S, FLAVELL, D, KERR, I. M, STARK, G. R

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Comparison of the potency and therapeutic efficacy of the anti-CD7 immunotoxin HB2-saporin constructed with one or two saporin moieties per immunotoxin molecule by FLAVELL, D. J, BOEHM, D. A, NOSS, A, FLAVELL, S. U

“…Immunotoxins that carry two toxin molecules to the target cell should in theory have a greater anti-tumour effect than those that carry just one. We have…”
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Mac 387 antibody and detection of formalin resistant myelomonocytic L1 antigen by Brandtzaeg, P, Jones, D B, Flavell, D J, Fagerhol, M K

“…The murine monoclonal antibody Mac 387 was raised against a purified protein fraction obtained from human monocytes. By immunoblotting experiments, Mac 387 was…”
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