Search Results - "Flaumenhaft, R."

Primary Human Lung Alveolus‐on‐a‐chip Model of Intravascular Thrombosis for Assessment of Therapeutics by Jain, A, Barrile, R, van der Meer, AD, Mammoto, A, Mammoto, T, Ceunynck, K, Aisiku, O, Otieno, MA, Louden, CS, Hamilton, GA, Flaumenhaft, R, Ingber, DE

“…Pulmonary thrombosis is a significant cause of patient mortality; however, there are no effective in vitro models of thrombi formation in human lung…”
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Probing for thiol isomerase activity in thrombi by Flaumenhaft, R.

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Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation by Bekendam, R. H., Iyu, D., Passam, F., Stopa, J. D., De Ceunynck, K., Muse, O., Bendapudi, P. K., Garnier, C. L., Gopal, S., Crescence, L., Chiu, J., Furie, B., Panicot‐Dubois, L., Hogg, P. J., Dubois, C., Flaumenhaft, R.

“…Essentials Nitric oxide synthesis controls protein disulfide isomerase (PDI) function. Nitric oxide (NO) modulation of PDI controls endothelial…”
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A journey with platelet P-selectin: the molecular basis of granule secretion, signalling and cell adhesion by Furie, B, Furie, B C, Flaumenhaft, R

“…P-selectin is a transmembrane protein that resides within the alpha granule membrane of unstimulated platelets. The "extracellular" domains face into the lumen…”
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Thrombus formation: direct real-time observation and digital analysis of thrombus assembly in a living mouse by confocal and widefield intravital microscopy by Celi, A, Merrill-Skoloff, G, Gross, P, Falati, S, Sim, D S, Flaumenhaft, R, Furie, B C, Furie, B

“…We have developed novel instrumentation using confocal and widefield microscopy to image and analyze thrombus formation in real time in the microcirculation of…”
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Discovery-based strategies for studying platelet function by Flaumenhaft, R, Dilks, J R

“…The platelet is an anucleate cell, complicating efforts to study platelet function by traditional genetic means. Discovery-based strategies have lead to the…”
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Fluoxetine (Prozac) augments platelet activation mediated through protease‐activated receptors by DILKS, J. R., FLAUMENHAFT, R.

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The extracellular regulation of growth factor action by Flaumenhaft, R, Rifkin, D B

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Role of the Latent TGF-β Binding Protein in the Activation of Latent TGF-β by Co-Cultures of Endothelial and Smooth Muscle Cells by Flaumenhaft, Robert, Abe, Mayumi, Sato, Yasufumi, Miyazono, Kohei, Harpel, John, Heldin, Carl-Henrik, Rifkin, Daniel B.

“…Transforming growth factor beta (TGF-β) is released from cells in a latent form consisting of the mature growth factor associated with an aminoterminal…”
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Basic Fibroblast Growth Factor-Induced Activation of Latent Transforming Growth Factor β in Endothelial Cells: Regulation of Plasminogen Activator Activity by Flaumenhaft, Robert, Abe, Mayumi, Mignatti, Paolo, Rifkin, Daniel B.

“…Exposure of bovine aortic or capillary endothelial cells to basic FGF (bFGF) for 1 h resulted in an approximately sixfold increase in plasminogen activator…”
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Heparin and Heparan Sulfate Increase the Radius of Diffusion and Action of Basic Fibroblast Growth Factor by Flaumenhaft, Robert, Moscatelli, David, Rifkin, Daniel B.

“…The radius of diffusion of basic FGF (bFGF) in the presence and in the absence of the glycosaminoglycans heparin and heparan sulfate was measured. Iodinated…”
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Ultrastructural Localization of Vesicle-associated Membrane Protein(s) to Specialized Membrane Structures in Human Pericytes, Vascular Smooth Muscle Cells, Endothelial Cells, Neutrophils, and Eosinophils by Feng, Dian, Flaumenhaft, Robert, Bandeira-Melo, Christianne, Weller, Peter F, Dvorak, Ann M

“…Vesicle-associated membrane proteins (VAMPs) are important to the trafficking of vesicles between membrane-bound intracytoplasmic organelles, in the…”
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Formation and fate of platelet microparticles by Flaumenhaft, Robert

“…There is increasing evidence that platelet microparticles participate in thrombus formation. Yet the origin of platelet microparticles and their fate in the…”
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Molecular Basis of Platelet Granule Secretion by Flaumenhaft, Robert

“…ABSTRACT—The energy-dependent release of granule contents from activated platelets is a well-established component of normal hemostasis and thrombosis. A role…”
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Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy by Göös, Helka, Fogarty, Christopher L., Sahu, Biswajyoti, Plagnol, Vincent, Rajamäki, Kristiina, Nurmi, Katariina, Liu, Xiaonan, Einarsdottir, Elisabet, Jouppila, Annukka, Pettersson, Tom, Vihinen, Helena, Krjutskov, Kaarel, Saavalainen, Päivi, Järvinen, Asko, Muurinen, Mari, Greco, Dario, Scala, Giovanni, Curtis, James, Nordström, Dan, Flaumenhaft, Robert, Vaarala, Outi, Kovanen, Panu E., Keskitalo, Salla, Ranki, Annamari, Kere, Juha, Lehto, Markku, Notarangelo, Luigi D., Nejentsev, Sergey, Eklund, Kari K., Varjosalo, Markku, Taipale, Jussi, Seppänen, Mikko R.J.

“…CCAAT enhancer–binding protein epsilon (C/EBPε) is a transcription factor involved in late myeloid lineage differentiation and cellular function. The only…”
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OC 36.2 Machine-Learning Based Risk Prediction of Cancer Associated Thrombosis: Internal, External, and Pre-Clinical Validation Studies by Patell, R., Karagkouni, D., Brake, M., Falanga, A., Marchetti, M., Russo, L., Mantha, S., Carrier, M., Wells, P., Neuberg, D., Ren, S., Flaumenhaft, R., Vlachos, I., Schulman, S., Zwicker, J.

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Phosphatidylinositol 4,5-bisphosphate mediates Ca2+-induced platelet alpha-granule secretion: evidence for type II phosphatidylinositol 5-phosphate 4-kinase function by Rozenvayn, N, Flaumenhaft, R

“…To understand the molecular basis of granule release from platelets, we examined the role of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) in…”
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VPS33B: let there be α-granules by Flaumenhaft, Robert

“…Comment on Lo et al, page Genesis of platelet dense granules has been studied largely by characterization of molecular defects in patients with syndromes that…”
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Shiga toxins do not directly stimulate alpha-granule secretion or enhance aggregation of human platelets by Thorpe, C M, Flaumenhaft, R, Hurley, B, Jacewicz, M, Acheson, D W, Keusch, G T

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The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretion by Flaumenhaft, Robert, Dilks, James R., Rozenvayn, Nataliya, Monahan-Earley, Rita A., Feng, Dian, Dvorak, Ann M.

“…Stimulation of platelets with strong agonists results in centralization of cytoplasmic organelles and secretion of granules. These observations have led to the…”
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