Search Results - "Flanagan, W."

The Impact of COVID‐19 Stay‐At‐Home Orders on Health Behaviors in Adults by Flanagan, Emily W., Beyl, Robbie A., Fearnbach, S. Nicole, Altazan, Abby D., Martin, Corby K., Redman, Leanne M.

“…Objective Stay‐at‐home orders in response to the coronavirus disease 2019 (COVID‐19) pandemic have forced abrupt changes to daily routines. This study assessed…”
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Calorie Restriction and Aging in Humans by Flanagan, Emily W, Most, Jasper, Mey, Jacob T, Redman, Leanne M

“…Calorie restriction (CR), the reduction of dietary intake below energy requirements while maintaining optimal nutrition, is the only known nutritional…”
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Factors Protecting against a Decline in Physical Activity during the COVID-19 Pandemic by FEARNBACH, S. NICOLE, FLANAGAN, EMILY W., HÖCHSMANN, CHRISTOPH, BEYL, ROBBIE A., ALTAZAN, ABBY D., MARTIN, CORBY K., REDMAN, LEANNE M.

“…The spread of COVID-19 and the associated stay-at-home orders and shutdowns of gyms and fitness centers have drastically influenced health behaviors leading to…”
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Phase I study of the anti-endothelin B receptor antibody-drug conjugate DEDN6526A in patients with metastatic or unresectable cutaneous, mucosal, or uveal melanoma by Sandhu, Shahneen, McNeil, Catriona M., LoRusso, Patricia, Patel, Manish R., Kabbarah, Omar, Li, Chunze, Sanabria, Sandra, Flanagan, W. Michael, Yeh, Ru-Fang, Brunstein, Flavia, Nazzal, Denise, Hicks, Rodney, Lemahieu, Vanessa, Meng, Raymond, Hamid, Omid, Infante, Jeffrey R.

“…Summary Background Endothelin B receptor (ET B R) is involved in melanoma pathogenesis and is overexpressed in metastatic melanoma. The antibody-drug conjugate…”
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Antimicrobial Proteins: Structure, Molecular Action, and Therapeutic Potential by Hassan, Mohamed, Flanagan, Thomas W, Kharouf, Naji, Bertsch, Christelle, Mancino, Davide, Haikel, Youssef

“…Second- and third-line treatments of patients with antibiotic-resistant infections can have serious side effects, such as organ failure with prolonged care and…”
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Eating Behaviors and Dietary Patterns of Women during Pregnancy: Optimizing the Universal 'Teachable Moment' by Kebbe, Maryam, Flanagan, Emily W, Sparks, Joshua R, Redman, Leanne M

“…Understanding women's perceptions of eating behaviors and dietary patterns can inform the 'teachable moment' model of pregnancy. Our objectives were to…”
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Productivity Costs of Work Loss Associated with Osteoarthritis in Canada from 2010 to 2031 by Sharif, Behnam, PhD, Garner, Rochelle, PhD, Hennessy, Deirdre, PhD, Sanmartin, Claudia, PhD, Flanagan, William M., BM, Marshall, Deborah A., PhD

“…Abstract (250) Objective To estimate and project the productivity costs of work loss (PCWL) associated with osteoarthritis (OA) in Canada using a…”
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Induction of Antimicrobial Protein S100A15 Expression by Oral Microbial Pathogens Is Toll-like Receptors-Dependent Activation of c-Jun-N-Terminal Kinase (JNK), p38, and NF-κB Pathways by Selimovic, Denis, Kharouf, Naji, Carrouel, Florence, Hassan, Sofie-Yasmin, Flanagan, Thomas W, Hassan, Sarah-Lilly, Megahed, Mosaad, Haikel, Youssef, Santourlidis, Simeon, Hassan, Mohamed

“…The antimicrobial protein S100A15 belongs to the S100 family, which is differentially expressed in a variety of normal and pathological tissues. Although the…”
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Projecting the direct cost burden of osteoarthritis in Canada using a microsimulation model by Sharif, B, Kopec, J, Bansback, N, Rahman, M.M, Flanagan, W.M, Wong, H, Fines, P, Anis, A

“…Summary Objectives To estimate the future direct cost of OA in Canada using a population-based health microsimulation model of osteoarthritis (POHEM-OA)…”
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Beyond weight loss: current perspectives on the impact of calorie restriction on healthspan and lifespan by Kebbe, Maryam, Sparks, Joshua R, Flanagan, Emily W, Redman, Leanne M

“…: Changes to mental, physical, and physiological functions drive the complex processes underlying the variable progression of human aging. Nutritional…”
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Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo by Kenski, Denise M, Cooper, Abby J, Li, Jenny J, Willingham, Aarron T, Haringsma, Henry J, Young, Tracy A, Kuklin, Nelly A, Jones, Jeffrey J, Cancilla, Mark T, McMasters, Daniel R, Mathur, Melina, Sachs, Alan B, Flanagan, W. Michael

“…Small interfering RNAs (siRNAs) are short, double-stranded RNAs that use the endogenous RNAi pathway to mediate gene silencing. Phosphorylation facilitates…”
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Nucleobase and Ribose Modifications Control Immunostimulation by a MicroRNA-122-mimetic RNA by Peacock, Hayden, Fucini, Raymond V, Jayalath, Prasanna, Ibarra-Soza, José M, Haringsma, Henry J, Flanagan, W. Michael, Willingham, Aarron, Beal, Peter A

“…Immune stimulation is a significant hurdle in the development of effective and safe RNA interference therapeutics. Here, we address this problem in the context…”
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Nicotine Downregulates the Compensatory Angiotensin-Converting Enzyme 2/Angiotensin Type 2 Receptor of the Renin-Angiotensin System by Yue, Xinping, Basting, Tyler M, Flanagan, Thomas W, Xu, Jiaxi, Lobell, Thomas D, Gilpin, Nicholas W, Gardner, Jason D, Lazartigues, Eric

“…Smoking is a major risk factor for the development of cardiovascular and pulmonary diseases. The importance of the renin-angiotensin system in the development…”
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ApoB siRNA-induced Liver Steatosis is Resistant to Clearance by the Loss of Fatty Acid Transport Protein 5 (Fatp5) by Ason, Brandon, Castro-Perez, Jose, Tep, Samnang, Stefanni, Alice, Tadin-Strapps, Marija, Roddy, Thomas, Hankemeier, Thomas, Hubbard, Brian, Sachs, Alan B., Michael Flanagan, W., Kuklin, Nelly A., Mitnaul, Lyndon J.

“…The association between hypercholesterolemia and elevated serum apolipoprotein B (APOB) has generated interest in APOB as a therapeutic target for patients at…”
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Single-stranded microRNA mimics by Chorn, Guillaume, Klein-McDowell, Molly, Zhao, Lihong, Saunders, Matthew A, Flanagan, W Michael, Willingham, Aarron T, Lim, Lee P

“…miRNAs are ∼22-nt RNAs that bind to the Argonaute family of proteins and have important regulatory roles in plants and animals. Here, we show that miRNAs…”
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The OncoSim model: development and use for better decision-making in Canadian cancer control by Gauvreau, C L, Fitzgerald, N R, Memon, S, Flanagan, W M, Nadeau, C, Asakawa, K, Garner, R, Miller, A B, Evans, W K, Popadiuk, C M, Wolfson, M, Coldman, A J

“…The Canadian Partnership Against Cancer was created in 2007 by the federal government to accelerate cancer control across Canada. Its OncoSim microsimulation…”
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mRNA knockdown by single strand RNA is improved by chemical modifications by Haringsma, Henry J, Li, Jenny J, Soriano, Ferdie, Kenski, Denise M, Flanagan, W Michael, Willingham, Aarron T

“…While RNAi has traditionally relied on RNA duplexes, early evaluation of siRNAs demonstrated activity of the guide strand in the absence of the passenger…”
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Maternal 24-h movement patterns across pregnancy and postpartum: The LIFE-Moms consortium by Kracht, Chelsea L., Drews, Kimberly L., Flanagan, Emily W., Keadle, Sarah K., Gallagher, Dympna, Van Horn, Linda, Haire-Joshu, Debra, Phelan, Suzanne, Pomeroy, Jeremy, Redman, Leanne M.

“…•Sleep decreased from early pregnancy to postpartum, but within an acceptable range.•Persons exhibited 40 more minutes of light physical activity…”
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CD133-Dependent Activation of Phosphoinositide 3-Kinase /AKT/Mammalian Target of Rapamycin Signaling in Melanoma Progression and Drug Resistance by Kharouf, Naji, Flanagan, Thomas W, Alamodi, Abdulhadi A, Al Hmada, Youssef, Hassan, Sofie-Yasmin, Shalaby, Hosam, Santourlidis, Simeon, Hassan, Sarah-Lilly, Haikel, Youssef, Megahed, Mossad, Brodell, Robert T, Hassan, Mohamed

“…Melanoma frequently harbors genetic alterations in key molecules leading to the aberrant activation of PI3K and its downstream pathways. Although the role of…”
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Impact of COVID-19 Stay-at-Home Orders on Health Behaviors and Anxiety in Black and White Americans by Sparks, Joshua R., Kebbe, Maryam, Flanagan, Emily W., Beyl, Robbie A., Altazan, Abby D., Yang, Shengping, Redman, Leanne M.

“…Background In the United States (US), the incidence and severity of COVID-19 infections, hospitalizations, and deaths are higher in Black compared to White…”
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