Search Results - "Flanagan, Paul K"

Alterations of mucosa-attached microbiome and epithelial cell numbers in the cystic fibrosis small intestine with implications for intestinal disease by Kelly, Jennifer, Al-Rammahi, Miran, Daly, Kristian, Flanagan, Paul K., Urs, Arun, Cohen, Marta C., di Stefano, Gabriella, Bijvelds, Marcel J. C., Sheppard, David N., de Jonge, Hugo R., Seidler, Ursula E., Shirazi-Beechey, Soraya P.

“…Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene. Defective CFTR leads to accumulation of…”
Get full text

Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease by Tawfik, Ahmed, Flanagan, Paul K, Campbell, Barry J

“…Multiple studies have demonstrated alterations in the intestinal microbial community(termed the microbiome) in Crohn’s disease(CD) and several lines of…”
Get full text

Comparative effectiveness of ustekinumab or vedolizumab after one year in 130 patients with anti‐TNF‐refractory Crohn’s disease by Townsend, Tristan, Razanskaite, Violeta, Dodd, Susanna, Storey, Daniel, Michail, Stephanie, Morgan, James, Davies, Michael, Penman, Douglas, Watters, Christopher, Swaminathan, Mira, Sabine, Joseph, Chapman, Adam, Smith, Philip J, Flanagan, Paul K., Reilly, Ian, Bodger, Keith, Subramanian, Sreedhar

“…Summary Background Anti‐tumour necrosis factor (TNF) agents are effective in Crohn's disease but some patients lose response and require alternative biologic…”
Get full text

Colonic mucosa-associated diffusely adherent afaC+ Escherichia coli expressing lpfA and pks are increased in inflammatory bowel disease and colon cancer by Prorok-Hamon, Maelle, Friswell, Melissa K, Alswied, Abdullah, Roberts, Carol L, Song, Fei, Flanagan, Paul K, Knight, Paul, Codling, Caroline, Marchesi, Julian R, Winstanley, Craig, Hall, Neil, Rhodes, Jonathan M, Campbell, Barry J

“…Colonic mucosa-associated Escherichia coli are increased in Crohn's disease (CD) and colorectal cancer (CRC). They variously haemagglutinate, invade epithelial…”
Get more information

Ustekinumab and Vedolizumab Are Equally Safe and Effective in Elderly Crohn’s Disease Patients by Gebeyehu, Gerum Gashaw, Fiske, Joseph, Liu, Eleanor, Limdi, Jimmy K., Broglio, Giacomo, Selinger, Christian, Razsanskaite, Violeta, Smith, Philip J., Flanagan, Paul K., Subramanian, Sreedhar

“…Background Anti-tumour necrosis factor (anti-TNF) agents are associated with increased infection risk among elderly inflammatory bowel disease (IBD) patients,…”
Get full text

Comparative Safety and Effectiveness of Ustekinumab and Anti-TNF in Elderly Crohn's Disease Patients by Gebeyehu, Gerum Gashaw, Broglio, Giacomo, Liu, Eleanor, Limdi, Jimmy K, Selinger, Christian, Fiske, Joseph, Razanskaite, Violeta, Smith, Philip J, Flanagan, Paul K, Subramanian, Sreedhar

“…Biologic therapies are associated with increased infection risk among elderly patients with inflammatory bowel disease (IBD). However, there are few data on…”
Get full text

Safety and effectiveness of ustekinumab in elderly Crohn’s disease patients by Fiske, Joseph, Liu, Eleanor, Limdi, Jimmy K., Conley, Thomas E., Townsend, Tristan, Davies, Mike, Brockwell, Robert, Baig, Daniyal, Abdelbadiee, Sherif, Uney, Anastasia, Liaros, Angela, Gaba, Waqas, Smith, Philip J., Flanagan, Paul K., Subramanian, Sreedhar

“…Anti-tumour necrosis factor (TNF) agents are associated with increased infection risk among elderly IBD patients, but little is known about non anti-TNF…”
Get full text

Randomized Trial of Ciprofloxacin Doxycycline and Hydroxychloroquine Versus Budesonide in Active Crohn’s Disease by Rhodes, Jonathan M., Subramanian, Sreedhar, Flanagan, Paul K., Horgan, Graham W., Martin, Kate, Mansfield, John, Parkes, Miles, Hart, Ailsa, Dallal, Helen, Iqbal, Tariq, Butterworth, Jeffrey, Culshaw, Kate, Probert, Christopher

“…Background Increased mucosa-associated E. coli are present in Crohn’s disease, but their role in pathogenesis is uncertain. Aims To assess efficacy and safety…”
Get full text

Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D by Flanagan, Paul K, Chiewchengchol, Direkrit, Wright, Helen L, Edwards, Steven W, Alswied, Abdullah, Satsangi, Jack, Subramanian, Sreedhar, Rhodes, Jonathan M, Campbell, Barry J

“…Crohn's disease (CD) is associated with defective innate immunity, including impaired neutrophil chemotaxis, and mucosal invasion by bacteria, particularly…”
Get full text

A rare cause of weight loss by Flanagan, Paul K, Coupland, Sarah E, Arumainathan, Arvind, Probert, Chris S J

Get more information

Lessons from diversion studies and antibacterial interventions by Flanagan, Paul K, Campbell, Barry J, Rhodes, Jonathan M

“…If bacteria cause IBD, then it should be possible to target the bacteria with therapies and cure or at least treat the disease. Discovery of a successful…”
Get more information

Corticosteroids in the Treatment of Pseudomembranous Colitis: A Report of 3 Cases by Sykes, Ella, McDonald, Patrick, Flanagan, Paul K

“…associated diarrhoea has been an increasing problem in the last decade in the UK and is a cause of significant morbidity. At the most severe end of the…”
Get full text

Safety and effectiveness of ustekinumab in elderly Crohn’s disease patients by Fiske, Joseph, Liu, Eleanor, Limdi, Jimmy K., Conley, Thomas E., Townsend, Tristan, Davies, Mike, Brockwell, Robert, Baig, Daniyal, Abdelbadiee, Sherif, Uney, Anastasia, Liaros, Angela, Gaba, Waqas, Smith, Philip J., Flanagan, Paul K., Subramanian, Sreedhar

Get full text

405: EFFICACY AND SAFETY OF ELECTIVE SWITCHING OF INFLAMAMTORY BOWEL DISEASE PATIENTS FROM INTRAVENOUS TO SUBCUTANEOUS INFLIXIMAB: A MULTI-CENTRE COHORT STUDY by Smith, Philip J., Critchley, Lisa, Storey, Daniel, Gregg, Belle, Stenson, June E., Kneebone, Andrew, Rimmer, Tracy, Burke, Stevena E., Hussain, Shamas, Teoh, Wan Yi, Vazeille, Stephan, Serna, Solange, Steel, Alan, Derbyshire, Edmund, Collins, Paul, Dibb, Martyn, Flanagan, Paul K., Probert, Christopher, Verma, Ajay M., Subramanian, Sreedhar

Get full text

Corticosteroids in the Treatment of Pseudomembranous Colitis: A Report of 3 Cases by Sykes, Ella, McDonald, Patrick, Flanagan, Paul K

Get full text