Search Results - "Flanagan, J M"

Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research by Shenker, N, Flanagan, J M

“…Epigenetics is the study of all mechanisms that regulate gene transcription and genome stability that are maintained throughout the cell division, but do not…”
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Review of processing and analysis methods for DNA methylation array data by Wilhelm-Benartzi, C S, Koestler, D C, Karagas, M R, Flanagan, J M, Christensen, B C, Kelsey, K T, Marsit, C J, Houseman, E A, Brown, R

“…The promise of epigenome-wide association studies and cancer-specific somatic DNA methylation changes in improving our understanding of cancer, coupled with…”
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Host epigenetic modifications by oncogenic viruses by FLANAGAN, J. M

“…Epigenetic alterations represent an important step in the initiation and progression of most human cancers, but it is difficult to differentiate the early…”
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Association of somatic DNA methylation variability with progression-free survival and toxicity in ovarian cancer patients by Flanagan, J.M., Wilhelm-Benartzi, C.S., Metcalf, M., Kaye, S.B., Brown, R.

“…We have addressed whether inter-individual methylation variation in somatic (white blood cells, WBCs) DNA of ovarian cancer patients provides potential for…”
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Nuclear Magnetic Dipole Interactions in Field-Oriented Proteins: Information for Structure Determination in Solution by Tolman, J. R., Flanagan, J. M., Kennedy, M. A., Prestegard, J. H.

“…The measurement of dipolar contributions to the splitting of15N resonances of1H-15N amide pairs in multidimensional high-field NMR spectra of field-oriented…”
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Structural Analysis of the Mechanism of Adenovirus Binding to Its Human Cellular Receptor, CAR by Bewley, Maria C., Springer, Karen, Zhang, Yian-Biao, Freimuth, Paul, Flanagan, John M.

“…Binding of virus particles to specific host cell surface receptors is known to be an obligatory step in infection even though the molecular basis for these…”
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The stroma of higher plant plastids contain ClpP and ClpC, functional homologs of Escherichia coli ClpP and ClpA: an archetypal two-component ATP-dependent protease by Shanklin, J. (Brookhaven National Laboratory, Upton, NY.), DeWitt, N.D, Flanagan, J.M

“…A cDNA representing the plastic-encoded homolog of the prokaryotic ATP-dependent protease ClpP was amplified by reverse transcription-polymerase chain…”
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Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices by LEMMON, M. A, FLANAGAN, J. M, HUNT, J. F, ADAIR, B. D, BORMANN, B.-J, DEMPSEY, C. E, ENGELMAN, D. M

“…Specific side-by-side interactions between transmembrane alpha-helices may be important in the assembly and function of integral membrane proteins. We describe…”
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NMR evidence for slow collective motions in cyanometmyoglobin by Tolman, J. R, Flanagan, J. M, Kennedy, M. A, Prestegard, J. H

“…Residual dipolar couplings observed in NMR spectra at very high magnetic fields have been measured to a high degree of accuracy for the paramagnetic protein…”
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Sequence specificity in the dimerization of transmembrane α-helices by LEMMON, M. A, FLANAGAN, J. M, TREUTLEIN, H. R, JIAN ZHANG, ENGELMAN, D. M

“…While several reports have suggested a role for helix-helix interactions in membrane protein oligomerization, there are few direct biochemical data bearing on…”
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Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease by Zinnanti, William J., Lazovic, Jelena, Griffin, Kathleen, Skvorak, Kristen J., Paul, Harbhajan S., Homanics, Gregg E., Bewley, Maria C., Cheng, Keith C., LaNoue, Kathryn F., Flanagan, John M.

“…Maple syrup urine disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with life-threatening cerebral oedema and…”
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Truncated Staphylococcal Nuclease is Compact but Disordered by Flanagan, John M., Kataoka, Mikio, Shortle, David, Engelman, Donald M.

“…Deletion of 13 amino acids from the carboxyl terminus of the 149-amino acid staphylococcal nuclease molecule results in a denatured, partly unfolded molecule…”
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The structure of ClpP at 2.3 angstrom resolution suggests a model for ATP-dependent proteolysis by Wang, J, Hartling, JA, Flanagan, J M

“…We have determined the crystal structure of the proteolytic component of the caseinolytic Clp protease (ClpP) from E. coli at 2.3 angstrom resolution using an…”
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Mutations can cause large changes in the conformation of a denatured protein by Flanagan, John M., Kataoka, Mikio, Fujisawa, Tetsuro, Engelman, Donald M.

“…Deletion of 13 amino acids from the carboxyl terminus of staphylococcal nuclease (WTSNase delta) results in a denatured, partially unfolded molecule that lacks…”
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Superficial bladder cancer: progression and recurrence by Heney, N M, Ahmed, S, Flanagan, M J, Frable, W, Corder, M P, Hafermann, M D, Hawkins, I R

“…The tumors in 249 patients presenting initially with stages Ta and T1 bladder cancer were analyzed for tumor progression and recurrence. Only transurethral…”
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The influence of C-terminal extension on the structure of the “J-domain” in E. coli DnaJ by HUANG, KAI, FLANAGAN, JOHN M., PRESTEGARD, JAMES H.

“…Two different recombinant constructs of the N-terminal domain in Escherichia coli DnaJ were uniformly labeled with nitrogen-15 and carbon-13. One, DnaJ(1–78),…”
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Spur-reduced digital sinusoid synthesis by Flanagan, M.J., Zimmerman, G.A.

“…This paper presents and analyzes a technique for reducing the spurious signal content in digital sinusoid synthesis. Spur reduction is accomplished through…”
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The role of human demographic history in determining the distribution and frequency of transferase-deficient galactosaemia mutations by Flanagan, J M, McMahon, G, Brendan Chia, S H, Fitzpatrick, P, Tighe, O, O'Neill, C, Briones, P, Gort, L, Kozak, L, Magee, A, Naughten, E, Radomyska, B, Schwartz, M, Shin, J S, Strobl, W M, Tyfield, L A, Waterham, H R, Russell, H, Bertorelle, G, Reichardt, J K V, Mayne, P D, Croke, D T

“…Classical or transferase-deficient galactosaemia is an inherited metabolic disorder caused by mutation in the human Galactose-1-phosphate uridyl transferase…”
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Renal Medullary Carcinoma in Patients with Sickle Cell Trait by Coogan, Christopher L., McKiel, Charles F., Flanagan, Malachi J., Bormes, Thomas P., Matkov, Thomas G.

“…Renal medullary carcinoma has recently been described as an aggressive neoplasm affecting young African Americans with sickle cell disease or sickle cell…”
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Self-compartmentalizing proteases by Lupas, Andrei, Flanagan, John M., Tamura, Tomohiro, Baumeister, Wolfgang

“…Among the hundreds of proteases characterized so far, most of which are monomeric or dimeric, there is a small group that form compartments through…”
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