Search Results - "Flamme, Ingo"

FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase by Flamme, Ingo, Ellinghaus, Peter, Urrego, Diana, Krüger, Thilo

“…Plasma levels of FGF23 are increased in patients with chronic kidney disease. Beside its role in phosphate homeostasis, iron deficiency and anemia are…”
Get full text

Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects by Flamme, Ingo, Oehme, Felix, Ellinghaus, Peter, Jeske, Mario, Keldenich, Jörg, Thuss, Uwe

“…Oxygen sensing by hypoxia-inducible factor prolyl hydroxylases (HIF-PHs) is the dominant regulatory mechanism of erythropoietin (EPO) expression. In chronic…”
Get full text

Discovery of Molidustat (BAY 85‐3934): A Small‐Molecule Oral HIF‐Prolyl Hydroxylase (HIF‐PH) Inhibitor for the Treatment of Renal Anemia by Beck, Hartmut, Jeske, Mario, Thede, Kai, Stoll, Friederike, Flamme, Ingo, Akbaba, Metin, Ergüden, Jens‐Kerim, Karig, Gunter, Keldenich, Jörg, Oehme, Felix, Militzer, Hans‐Christian, Hartung, Ingo V., Thuss, Uwe

“…Small‐molecule inhibitors of hypoxia‐inducible factor prolyl hydroxylases (HIF‐PHs) are currently under clinical development as novel treatment options for…”
Get full text

Pharmacodynamic effects of molidustat on erythropoiesis in healthy cats by Boegel, Annette, Flamme, Ingo, Krebber, Ralph, Settje, Terry, Schmidt, Franziska, Kruedewagen, Eva, Mangold‐Gehring, Sandra, Lainesse, Chantal, Moritz, Andreas, Beddies, Gerald

“…Background Inhibition of hypoxia‐inducible factor prolyl hydroxylase (HIF‐PH) stimulates erythropoiesis in rats, dogs, monkeys, and humans…”
Get full text

BAY 87‐2243, a highly potent and selective inhibitor of hypoxia‐induced gene activation has antitumor activities by inhibition of mitochondrial complex I by Ellinghaus, Peter, Heisler, Iring, Unterschemmann, Kerstin, Haerter, Michael, Beck, Hartmut, Greschat, Susanne, Ehrmann, Alexander, Summer, Holger, Flamme, Ingo, Oehme, Felix, Thierauch, Karlheinz, Michels, Martin, Hess‐Stumpp, Holger, Ziegelbauer, Karl

“…The activation of the transcription factor hypoxia‐inducible factor‐1 (HIF‐1) plays an essential role in tumor development, tumor progression, and resistance…”
Get full text

Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors by Hamada, Shohei, Suzuki, Takayoshi, Mino, Koshiki, Koseki, Koichi, Oehme, Felix, Flamme, Ingo, Ozasa, Hiroki, Itoh, Yukihiro, Ogasawara, Daisuke, Komaarashi, Haruka, Kato, Aiko, Tsumoto, Hiroki, Nakagawa, Hidehiko, Hasegawa, Makoto, Sasaki, Ryuzo, Mizukami, Tamio, Miyata, Naoki

“…Selective inhibitors of Jumonji domain-containing protein (JMJD) histone demethylases are candidate anticancer agents as well as potential tools for…”
Get full text

Prolyl Hydroxylases 2 and 3 Act in Gliomas as Protective Negative Feedback Regulators of Hypoxia-Inducible Factors by HENZE, Anne-Theres, RIEDEL, Johanna, DIEM, Tanja, WENNER, Julia, FLAMME, Ingo, POUYSEGGUR, Jacques, PLATE, Karl H, ACKER, Till

“…Adaptive responses to hypoxia in tumors are transcriptionally regulated by the hypoxia inducible factors (HIF-1alpha/HIF-2alpha), which are tightly controlled…”
Get full text

Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation by Martin, Falk, Linden, Tobias, Katschinski, Dörthe M., Oehme, Felix, Flamme, Ingo, Mukhopadhyay, Chinmay K., Eckhardt, Katrin, Tröger, Juliane, Barth, Sandra, Camenisch, Gieri, Wenger, Roland H.

“…Cellular oxygen partial pressure is sensed by a family of prolyl-4-hydroxylase domain (PHD) enzymes that modify hypoxia-inducible factor (HIF)α subunits. Upon…”
Get full text

Vasculogenesis by Risau, Werner, Flamme, Ingo

“…Induction by fibroblast growth factors of mesoderm during gastrulation leads to blood-forming tissue, including angioblasts and hemopoietic cells, that…”
Get full text

Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function by KRIEG, Marion, HAAS, Richard, BRAUCH, Hiltrud, ACKER, Till, FLAMME, Ingo, PLATE, Karl H

“…Hypoxia induces transcription of a range of physiologically important genes including erythropoietin and vascular endothelial growth factor. The…”
Get full text

Nuclear Oxygen Sensing: Induction of Endogenous Prolyl-hydroxylase 2 Activity by Hypoxia and Nitric Oxide by Berchner-Pfannschmidt, Utta, Tug, Suzan, Trinidad, Buena, Oehme, Felix, Yamac, Hatice, Wotzlaw, Christoph, Flamme, Ingo, Fandrey, Joachim

“…The abundance of the transcription factor hypoxia-inducible factor is regulated through hydroxylation of its α-subunits by a family of prolyl-hydroxylases…”
Get full text

Expression and Proteolysis of Vascular Endothelial Growth Factor is Increased in Chronic Wounds by Lauer, Gereon, Sollberg, Stephan, Cole, Melanie, Krieg, Thomas, Eming, Sabine A., Flamme, Ingo, Stürzebecher, Jörg, Mann, Karlheinz

“…Degradation of angiogenic mediators might be an underlying cause of chronic wounds. To test this hypothesis, we evaluated the expression and integrity of…”
Get full text

Molecular mechanisms of vasculogenesis and embryonic angiogenesis by Flamme, Ingo, Frölich, Thomas, Risau, Werner

Get full text

Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development by Licht, Alexander H., Müller-Holtkamp, Felix, Flamme, Ingo, Breier, Georg

“…Hypoxia-inducible factors (HIFs) are transcriptional regulators that mediate the cellular response to low oxygen levels. By stimulating the expression of…”
Get full text

Identification of Vascular Endothelial Growth Factor (VEGF) Receptor-2 (Flk-1) Promoter/Enhancer Sequences Sufficient for Angioblast and Endothelial Cell-Specific Transcription in Transgenic Mice by Kappel, Andreas, Rönicke, Volker, Damert, Annette, Flamme, Ingo, Risau, Werner, Breier, Georg

“…The vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) is the first endothelial receptor tyrosine kinase to be expressed in angioblast precursors,…”
Get full text

Identification of Vascular Endothelial Growth Factor (VEGF) Receptor-2 (Flk-1) Promoter/Enhancer Sequences Sufficient for Angioblast and Endothelial Cell-Specific Transcription in Transgenic Mice by Kappel, Andreas, Rönicke, Volker, Damert, Annette, Flamme, Ingo, Risau, Werner, Breier, Georg

“…The vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) is the first endothelial receptor tyrosine kinase to be expressed in angioblast precursors,…”
Get full text

Vascular Endothelial Growth Factor (VEGF) and VEGF Receptor 2(flk-1) Are Expressed during Vasculogenesis and Vascular Differentiation in the Quail Embryo by Flamme, Ingo, Breier, Georg, Risau, Werner

“…Vasculogenesis, the de novo formation of embryonic blood vessels from their angioblastic precursors in situ, is supposed to be under the control of polypeptide…”
Get full text

Role of SCL/Tal-1, GATA, and Ets transcription factor binding sites for the regulation of Flk-1 expression during murine vascular development by Kappel, Andreas, Schlaeger, Thorsten M., Flamme, Ingo, Orkin, Stuart H., Risau, Werner, Breier, Georg

“…The receptor tyrosine kinase Flk-1 is essential for embryonic blood vessel development and for tumor angiogenesis. To identify upstream transcriptional…”
Get full text

Induction of vasculogenesis and hematopoiesis in vitro by FLAMME, I, RISAU, W

“…Despite a large number of investigations of embryonic vascular development, in particular in avian embryos, the conditions under which the endothelial and…”
Get full text

A nonradioactive 96-well plate assay for the detection of hypoxia-inducible factor prolyl hydroxylase activity by Oehme, Felix, Jonghaus, Willi, Narouz-Ott, Laila, Huetter, Joachim, Flamme, Ingo

“…The transcriptional activation of hypoxia-inducible genes is essential for the adaptation of mammalian tissues to oxygen deficiency. The hypoxia-inducible…”
Get full text