Search Results - "Flake, Gordon P."

Glypican 6 is a putative biomarker for metastatic progression of cutaneous melanoma by Li, Yuanyuan, Li, Melissa, Shats, Igor, Krahn, Juno M, Flake, Gordon P, Umbach, David M, Li, Xiaoling, Li, Leping

“…Due to the poor prognosis of advanced metastatic melanoma, it is crucial to find early biomarkers that help identify which melanomas will metastasize. By…”
Get full text

Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies by Patial, Sonika, Curtis, Alan D., Lai, Wi S., Stumpo, Deborah J., Hill, Georgette D., Flake, Gordon P., Mannie, Mark D., Blackshear, Perry J.

“…Tristetraprolin (TTP) is an inducible, tandem zinc-finger mRNA binding protein that binds to adenylate-uridylate–rich elements (AREs) in the 3′-untranslated…”
Get full text

Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver by Hori, Takeshi, Saito, Kosuke, Moore, Rick, Flake, Gordon P, Negishi, Masahiko

“…Phenobarbital, a nongenotoxic hepatocarcinogen, induces hepatic proliferation and promotes development of hepatocellular carcinoma (HCC) in rodents. Nuclear…”
Get full text

Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats by Palmer, Scott M, Flake, Gordon P, Kelly, Fran L, Zhang, Helen L, Nugent, Julia L, Kirby, Patrick J, Foley, Julie F, Gwinn, William M, Morgan, Dan L

“…Bronchiolitis obliterans (BO) is a fibrotic lung disease that occurs in a variety of clinical settings, including toxin exposures, autoimmunity and lung or…”
Get full text

Respiratory Toxicity of Diacetyl in C57Bl/6 Mice by Morgan, Daniel L., Flake, Gordon P., Kirby, Patrick J., Palmer, Scott M.

“…Diacetyl, a component of artificial butter flavoring, is a potential etiological agent of obliterative bronchiolitis (OB); however, the toxic dose and…”
Get full text

Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice by Deng, Yangmei, Edin, Matthew L., Theken, Katherine N., Schuck, Robert N., Flake, Gordon P., Kannon, M. Alison, DeGraff, Laura M., Lih, Fred B., Foley, Julie, Bradbury, J. Alyce, Graves, Joan P., Tomer, Kenneth B., Falck, John R., Zeldin, Darryl C., Lee, Craig R.

“…ABSTRACT Cytochrome P‐450 (CYP)‐derived epoxyei‐cosatrienoic acids (EETs) possess potent anti‐inflammatory effects in vitro. However, the effect of increased…”
Get full text

Gender Differences in Murine Airway Responsiveness and Lipopolysaccharide-Induced Inflammation by Card, Jeffrey W, Carey, Michelle A, Bradbury, J. Alyce, DeGraff, Laura M, Morgan, Daniel L, Moorman, Michael P, Flake, Gordon P, Zeldin, Darryl C

“…The roles of gender and sex hormones in lung function and disease are complex and not completely understood. The present study examined the influence of gender…”
Get full text

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice by Hoopes, Samantha L, Gruzdev, Artiom, Edin, Matthew L, Graves, Joan P, Bradbury, J Alyce, Flake, Gordon P, Lih, Fred B, DeGraff, Laura M, Zeldin, Darryl C

“…Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure…”
Get full text

Effects of Combined Tristetraprolin/Tumor Necrosis Factor Receptor Deficiency on the Splenic Transcriptome by Patial, Sonika, Stumpo, Deborah J., Young, W. Scott, Ward, James M., Flake, Gordon P., Blackshear, Perry J.

“…Tristetraprolin (TTP) acts by binding to AU-rich elements in certain mRNAs, such as tumor necrosis factor (TNF) mRNA, and increasing their decay rates. TTP…”
Get full text

Gene expression in obliterative bronchiolitis-like lesions in 2,3-pentanedione-exposed rats by Morgan, Daniel L, Merrick, B Alex, Gerrish, Kevin E, Stockton, Patricia S, Wang, Yu, Foley, Julie F, Gwinn, William M, Kelly, Francine L, Palmer, Scott M, Ton, Thai-Vu T, Flake, Gordon P

“…Obliterative bronchiolitis (OB) is an irreversible lung disease characterized by progressive fibrosis in the small airways with eventual occlusion of the…”
Get full text

Evaluation of propargyl alcohol toxicity and carcinogenicity in F344/N rats and B6C3F1/N mice following whole-body inhalation exposure by Thakur, Sheetal A, Flake, Gordon P, Travlos, Greg S, Dill, Jeffrey A, Grumbein, Sondra L, Harbo, Sam J, Hooth, Michelle J

“…Abstract Propargyl alcohol (PA) is a high production volume chemical used in synthesis of many industrial chemicals and agricultural products. Despite the…”
Get full text

Urogenital epithelial cells as simple markers of estrogen response in infants: methods and applications by Adgent, Margaret A, Flake, Gordon P, Umbach, David M, Stallings, Virginia A, Bernbaum, Judy C, Rogan, Walter J

“…Exposure to estrogen-mimicking chemicals during critical periods of development, such as infancy, may have adverse effects. However, these effects can be…”
Get full text

The Life Cycle of the Uterine Fibroid Myocyte by Flake, Gordon P., Moore, Alicia B., Sutton, Deloris, Flagler, Norris, Clayton, Natasha, Kissling, Grace E., Hall, Benita Wicker, Horton, John, Walmer, David, Robboy, Stanley J., Dixon, Darlene

“…Purpose of Review Uterine fibroids are common benign tumors of women in the USA and worldwide, yet the biological nature and pathogenesis of these tumors…”
Get full text

Modulation of Allergic Airway Inflammation by the Oral Pathogen Porphyromonas gingivalis by Card, Jeffrey W, Carey, Michelle A, Voltz, James W, Bradbury, J. Alyce, Ferguson, Catherine D, Cohen, Eric A, Schwartz, Samuel, Flake, Gordon P, Morgan, Daniel L, Arbes, Samuel J. Jr, Barrow, David A, Barros, Silvana P, Offenbacher, Steven, Zeldin, Darryl C

“…Accumulating evidence suggests that bacteria associated with periodontal disease may exert systemic immunomodulatory effects. Although the improvement in oral…”
Get full text

Pathology of Diacetyl and 2,3-Pentanedione Airway Lesions in a Rat Model of Obliterative Bronchiolitis by Flake, Gordon P, Morgan, Daniel L

“…Abstract Inhalation of diacetyl vapors by workers has been associated with obliterative bronchiolitis (OB), a poorly understood fibroproliferative disease of…”
Get full text

Immunohistochemical Investigation of F344/N Rat Islet Cell Tumors from National Toxicology Program Studies by Koivisto, Christopher, Flake, Gordon P., Kolenda-Roberts, Holly, Masinde, Tiwanda, Kissling, Grace E., Sills, Robert C., Hoenerhoff, Mark J.

“…In this study, we have investigated the immunoexpression of peptide hormones and mediators associated with human islet cell tumors in a group of proliferative…”
Get full text

Etiology and Pathogenesis of Uterine Leiomyomas: A Review by Flake, Gordon P., Andersen, Janet, Dixon, Darlene

“…Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become…”
Get full text

The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens by Wilson, Rhonda H, Maruoka, Shuichiro, Whitehead, Gregory S, Foley, Julie F, Flake, Gordon P, Sever, Michelle L, Zeldin, Darryl C, Kraft, Monica, Garantziotis, Stavros, Nakano, Hideki, Cook, Donald N

“…House dust promotes allergic responses to inhaled allergens, but it remains unclear what microbial components in dust are required for this activity. Donald N…”
Get full text

TNF is required for TLR ligand-mediated but not protease-mediated allergic airway inflammation by Whitehead, Gregory S, Thomas, Seddon Y, Shalaby, Karim H, Nakano, Keiko, Moran, Timothy P, Ward, James M, Flake, Gordon P, Nakano, Hideki, Cook, Donald N

“…Asthma is associated with exposure to a wide variety of allergens and adjuvants. The extent to which overlap exists between the cellular and molecular…”
Get full text

The Natural History of Uterine Leiomyomas: Light and Electron Microscopic Studies of Fibroid Phases, Interstitial Ischemia, Inanosis, and Reclamation by Flake, Gordon P., Moore, Alicia B., Sutton, Deloris, Kissling, Grace E., Horton, John, Wicker, Benita, Walmer, David, Robboy, Stanley J., Dixon, Darlene

“…We propose, and offer evidence to support, the concept that many uterine leiomyomas pursue a self-limited life cycle. This cycle can be arbitrarily divided on…”
Get full text