Search Results - "Flaherty, Katie R"

Divergent Impact of Glucose Availability on Human Virus-Specific and Generically Activated CD8 T Cells by Sanchez, Jenifer, Jackson, Ian, Flaherty, Katie R., Muliaditan, Tamara, Schurich, Anna

“…Upon activation T cells engage glucose metabolism to fuel the costly effector functions needed for a robust immune response. Consequently, the availability of…”
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Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors by Muliaditan, Tamara, Halim, Leena, Whilding, Lynsey M., Draper, Benjamin, Achkova, Daniela Y., Kausar, Fahima, Glover, Maya, Bechman, Natasha, Arulappu, Appitha, Sanchez, Jenifer, Flaherty, Katie R., Obajdin, Jana, Grigoriadis, Kristiana, Antoine, Pierre, Larcombe-Young, Daniel, Hull, Caroline M., Buus, Richard, Gordon, Peter, Grigoriadis, Anita, Davies, David M., Schurich, Anna, Maher, John

“…Second generation (2G) chimeric antigen receptors (CARs) contain a CD28 or 41BB co-stimulatory endodomain and elicit remarkable efficacy in hematological…”
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Efficacy of PD-1 checkpoint inhibitor therapy in melanoma and beyond: are peripheral T cell phenotypes the key? by Flaherty, Katie R, Kucykowicz, Stephanie, Schroth, Johannes, Traves, Will, Mincham, Kyle T, Finney, George E

“…Summary Immunotherapy treatment strategies have proven effective in a limited portion of patients, where identifying responders from non-responders to…”
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Solid tumor immunotherapy using NKG2D-based adaptor CAR T cells by Obajdin, Jana, Larcombe-Young, Daniel, Glover, Maya, Kausar, Fahima, Hull, Caroline M., Flaherty, Katie R., Tan, Ge, Beatson, Richard E., Dunbar, Phoebe, Mazza, Roberta, Bove, Camilla, Taylor, Chelsea, Bille, Andrea, Spillane, Katelyn M., Cozzetto, Domenico, Vigilante, Alessandra, Schurich, Anna, Davies, David M., Maher, John

“…NKG2D ligands (NKG2DLs) are broadly expressed in cancer. To target these, we describe an adaptor chimeric antigen receptor (CAR) termed NKG2D/Dap10-12. Herein,…”
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