Search Results - "Flagg, Thomas"

Muscle KATP channels: recent insights to energy sensing and myoprotection by Flagg, Thomas P, Enkvetchakul, Decha, Koster, Joseph C, Nichols, Colin G

“…ATP-sensitive potassium (K(ATP)) channels are present in the surface and internal membranes of cardiac, skeletal, and smooth muscle cells and provide a unique…”
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Considerations for Optimizing Warfighter Psychological Health with a Research-Based Flavonoid Approach: A Review by Currie, Tanisha L, Engler, Marguerite M, Krauthamer, Victor, Scott, Jonathan M, Deuster, Patricia A, Flagg, Thomas P

“…Optimal nutrition is imperative for psychological health. Oxidative stress and inflammation are underlying etiologies for alterations in psychological health…”
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Balancing Conservation and Harvest Objectives: a Review of Considerations for the Management of Salmon Hatcheries in the U.S. Pacific Northwest by Flagg, Thomas A.

“…The U.S. Pacific Northwest (PNW) has one of the largest suites of hatchery programs for anadromous salmonids in the world, with about 500 programs producing…”
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The Effects of Berry Extracts on Oxidative Stress in Cultured Cardiomyocytes and Microglial Cells: A Potential Cardioprotective and Neuroprotective Mechanism by Currie, Tanisha L, Engler, Marguerite M, Olsen, Cara H, Krauthamer, Victor, Scott, Jonathan M, Deuster, Patricia A, Flagg, Thomas P

“…Oxidative stress is a key underlying factor in cognitive decline and atherosclerosis. Oxidative stress occurs at the cellular level with an imbalance between…”
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The Effects of Blackcurrant and Berry Extracts on Oxidative Stress in Cultured Cardiomyocytes and Microglial Cells by Currie, Tanisha L., Engler, Marguerite M., Olsen, Cara H., Krauthamer, Victor, Scott, Jonathan M., Deuster, Patricia A., Flagg, Thomas P.

“…Background Cardiovascular disease (CVD) is the number one cause of morbidity and mortality for both men and women in the U.S; to include our military…”
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Dangerous Needle Stick by Krantz, Mori J., Flagg, Thomas P., Haigney, Mark C.P.

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Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes by Fatima, Naheed, Schooley, Jr, James F, Claycomb, Willliam C, Flagg, Thomas P

“…Two mammalian genes encode the SURx (SUR1, Abcc8 and SUR2, Abcc9) subunits that combine with Kir6.2 (Kcnj11) subunits to form the ATP-sensitive potassium…”
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Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation by Vasudevan, Narayanan Puthillathu, Soni, Dharmendra K, Moffett, John R, Krishnan, Jishnu K S, Appu, Abhilash P, Ghoshal, Sarani, Arun, Peethambaran, Denu, John M, Flagg, Thomas P, Biswas, Roopa, Namboodiri, Aryan M

“…The coordination of cellular biological processes is regulated in part via metabolic enzymes acting to match cellular metabolism to current conditions. The…”
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Putting the Red Back in Redfish Lake, 20 Years of Progress Toward Saving the Pacific Northwest's Most Endangered Salmon Population by Kline, Paul A, Flagg, Thomas A

“…In November 1991, the U.S. National Marine Fisheries Service listed Snake River Sockeye Salmon (Oncorhynchus nerka) as endangered under the U.S. Endangered…”
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Avoiding the chopping block in curricular reform: reimagining physiology laboratories in the era of integrated medical curricula by Flagg, Thomas P, Rothwell, Stephen, Neubauer, Brian

“…For the past 100 yr or so, the Flexner 2+2 model of medical education has been the dominant paradigm for undergraduate medical curricula. The recognition of…”
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Cardiac sarcolemmal KATP channels: Latest twists in a questing tale by Zhang, Haixia, Flagg, Thomas P, Nichols, Colin G

“…Abstract Reconstitution of KATP channel activity from coexpression of members of the pore-forming inward rectifier gene family (Kir6.1, KCNJ8 , and Kir6.2…”
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Methadone Blockade of Cardiac Inward Rectifier K + Current Augments Membrane Instability and Amplifies U Waves on Surface ECGs: A Translational Study by Klein, Michael G, Krantz, Mori J, Fatima, Naheed, Watters, Ashlie, Colon-Sanchez, Dayan, Geiger, Robert M, Goldstein, Robert E, Solhjoo, Soroosh, Mehler, Philip S, Flagg, Thomas P, Haigney, Mark C

“…Background Methadone is associated with a disproportionate risk of sudden death and ventricular tachyarrhythmia despite only modest inhibition of delayed…”
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Differential Structure of Atrial and Ventricular KATP: Atrial KATP Channels Require SUR1 by Flagg, Thomas P, Kurata, Harley T, Masia, Ricard, Caputa, George, Magnuson, Mark A, Lefer, David J, Coetzee, William A, Nichols, Colin G

“…The isoform-specific structure of the ATP-sensitive potassium (KATP) channel endows it with differential fundamental properties, including physiological…”
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Potent Inhibition of hERG Channels by the Over-the-Counter Antidiarrheal Agent Loperamide by Klein, Michael G., PhD, Haigney, Mark C.P., MD, Mehler, Philip S., MD, Fatima, Naheed, PhD, Flagg, Thomas P., PhD, Krantz, Mori J., MD

“…Abstract Objectives The aim of this study was to determine the in vitro electrophysiological properties of loperamide. The authors’ hypothesis was that…”
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Role of Suppression of the Inward Rectifier Current (IK1) on Terminal Action Potential Repolarization in the Failing Heart by Klein, Michael G., PhD, Shou, Matie, MD, Stohlman, Jayna, PhD, Sohljoo, Soroosh, PhD, Haigney, Myles, Tidwell, Richard R., PhD, Goldstein, Robert E., MD, Flagg, Thomas P., PhD, Haigney, Mark C., MD

“…Abstract Background The failing heart exhibits an increased arrhythmia susceptibility that is often attributed to action potential (AP) prolongation due to…”
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Differential KATP channel pharmacology in intact mouse heart by Glukhov, Alexey V, Flagg, Thomas P, Fedorov, Vadim V, Efimov, Igor R, Nichols, Colin G

“…Abstract Classically, cardiac sarcolemmal KATP channels have been thought to be composed of Kir6.2 (KCNJ11) and SUR2A (ABCC9) subunits. However, the evidence…”
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Hemodynamic Effects of Late Sodium Current Inhibitors in a Swine Model of Heart Failure by Goldstein, Robert E., Klein, Michael G., Ouimet, Sean P., Shou, Matie, Hood, Maureen N., Flagg, Thomas P., Haigney, Mark C.

“…•Ranolazine or mexiletine do not adversely affect swine with advanced heart failure.•In vivo drug levels shortened action potential duration prolonged by heart…”
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Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel by NOONAN, Anne M, EISCH, Robin A, BATES, Susan E, LIEWEHR, David J, SISSUNG, Tristan M, VENZON, David J, FLAGG, Thomas P, HAIGNEY, Mark C, STEINBERG, Seth M, FIGG, William D, PIEKARZ, Richard L

“…Purpose: Romidepsin is a histone deacetylase inhibitor (HDI) approved for the treatment of both cutaneous and peripheral T-cell lymphoma (CTCL and PTCL)…”
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Distinct Cellular and Molecular Mechanisms Underlie Functional Remodeling of Repolarizing K+ Currents With Left Ventricular Hypertrophy by Marionneau, Céline, Brunet, Sylvain, Flagg, Thomas P, Pilgram, Thomas K, Demolombe, Sophie, Nerbonne, Jeanne M

“…Left ventricular hypertrophy (LVH) is associated with electric remodeling and increased arrhythmia risk, although the underlying mechanisms are poorly…”
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SMN-deficiency disrupts SERCA2 expression and intracellular Ca2+ signaling in cardiomyocytes from SMA mice and patient-derived iPSCs by Khayrullina, Guzal, Moritz, Kasey E, Schooley, James F, Fatima, Naheed, Viollet, Coralie, McCormack, Nikki M, Smyth, Jeremy T, Doughty, Martin L, Dalgard, Clifton L, Flagg, Thomas P, Burnett, Barrington G

“…Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by loss of alpha motor neurons and skeletal muscle atrophy. The disease is caused by…”
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