Search Results - "Flögel, Oliver"

Efficient Syntheses of 2,5‐Dihydropyrroles, Pyrrolidin‐3‐ones, and Electron‐Rich Pyrroles from N‐Tosylimines and Lithiated Alkoxyallenes by Okala Amombo, Ghislaine Marlyse, Flögel, Oliver, Kord Daoroun Kalai, Scheghajeh, Schoder, Stefan, Warzok, Ulrike, Reissig, Hans‐Ulrich

“…N‐Tosylimines and lithiated alkoxyallenes afforded the corresponding allenyl N‐tosylamines in good to excellent yields. The 5‐endo‐trig cyclizations of these…”
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1998-2003: El Impacto de desequilibrios económicos en el valor de los operadores de telecomunicaciones by Alexander Flögel, Oliver

“…Las operadoras de telecomunicaciones son parte de un sistema económico que debe mantenerse en equilibrio para su desarrollo sustentable. La evolución de la…”
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Microreactor Synthesis of β-Peptides by Flögel, Oliver, Codée, Jeroen D. C., Seebach, Dieter, Seeberger, Peter H.

“…Taming the insoluble: The reaction parameters of a β‐peptide synthesis were optimized using only small amounts of reagents in a silicon microreactor (see…”
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A New Color of the Synthetic Chameleon Methoxyallene: Synthesis of Trifluoromethyl-Substituted Pyridinol Derivatives: An Unusual Reaction Mechanism, a Remarkable Crystal Packing, and First Palladium-Catalyzed Coupling Reactions by Flögel, Oliver, Dash, Jyotirmayee, Brüdgam, Irene, Hartl, Hans, Reißig, Hans-Ulrich

“…Addition of lithiated methoxyallene to pivalonitrile afforded after aqueous workup the expected iminoallene 1 in excellent yield. Treatment of this…”
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Synthesis, and Helix or Hairpin-Turn Secondary Structures of 'Mixed' α/β-Peptides Consisting of Residues with Proteinogenic Side Chains and of 2-Amino-2-methylpropanoic Acid (Aib) by Seebach, Dieter, Jaun, Bernhard, Sebesta, Radovan, Mathad, Raveendra I., Flögel, Oliver, Limbach, Michael, Sellner, Holger, Cottens, Sylvain

“…Twelve peptides, 1–12, have been synthesized, which consist of alternating sequences of α‐ and β‐amino acid residues carrying either proteinogenic side chains…”
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NMR‐Solution Structures of Fluoro‐Substituted β ‐Peptides: A 3 14 ‐Helix and a Hairpin Turn. The First Case of a 90° OCCF Dihedral Angle in an α ‐Fluoro‐Amide Group by Mathad, Raveendra I., Jaun, Bernhard, Flögel, Oliver, Gardiner, James, Löweneck, Markus, Codée, Jeroen D. C., Seeberger, Peter H., Seebach, Dieter, Edmonds, Michael K., Graichen, Florian H. M., Abell, Andrew D.

“…Abstract To further study the preference of the antiperiplanar ( ap ) conformation in α ‐fluoro‐amide groups, two β ‐peptides, 1 and 2 , containing a (2‐F)‐ β…”
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Enzyme-Catalyzed Formation of β-Peptides: β-Peptidyl Aminopeptidases BapA and DmpA Acting as β-Peptide-Synthesizing Enzymes by Heck, Tobias, Kohler, Hans-Peter E., Limbach, Michael, Flögel, Oliver, Seebach, Dieter, Geueke, Birgit

“…In recent studies, we discovered that the three β‐peptidyl aminopeptidases, BapA from Sphingosinicella xenopeptidilytica 3‐2W4, BapA from S. microcystinivorans…”
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Preparation of α,β-Unsaturated γ-Keto Aldehydes and New Tetronic Acid and Pyridazine Derivatives by Oxidative Transformations of Alkoxyallene-Based Dihydrofurans by Flögel, Oliver, Reißig, Hans-Ulrich

“…Oxidation of 3‐alkoxy‐substituted dihydrofuran derivatives 6 and 11 with DDQ unexpectedly provided α,β‐unsaturated γ‐keto aldehydes 10 and 12. A mechanism for…”
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A Stereoselective and Short Total Synthesis of the Polyhydroxylated γ-Amino Acid (−)-Detoxinine, Based on Stereoselective Preparation of Dihydropyrrole Derivatives from Lithiated Alkoxyallenes by Flögel, Oliver, Okala Amombo, Marlyse Ghislaine, Reißig, Hans-Ulrich, Zahn, Gernot, Brüdgam, Irene, Hartl, Hans

“…Based on our earlier results employing lithiated methoxyallene 2 as C3 building block and imines 3 for the synthesis of dihydropyrrole derivatives 5, we have…”
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β-Peptide Conjugates: Syntheses and CD and NMR Investigations of β/α-Chimeric Peptides, of a DPA-β-Decapeptide, and of a PEGylated β-Heptapeptide by Gardiner, James, Mathad, Raveendra I., Jaun, Berhard, Schreiber, Jürg V., Flögel, Oliver, Seebach, Dieter

“…β3‐Peptides consisting of six, seven, and ten homologated proteinogenic amino acid residues have been attached to an α‐heptapeptide (all d‐amino acid residues;…”
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Preparation of the β3-Homoselenocysteine Derivatives Fmoc-β3hSec(PMB)-OH and Boc-β3hSec(PMB)-OH for Solution and Solid-Phase-Peptide Synthesis and Selenoligation by Flögel, Oliver, Casi, Giulio, Hilvert, Donald, Seebach, Dieter

“…The title compounds, 4 and 7, have been prepared from the corresponding α‐amino acid derivative selenocystine (1) by the following sequence of steps: cleavage…”
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Preparation of the β 3 ‐Homoselenocysteine Derivatives Fmoc‐ β 3 hSec(PMB)‐OH and Boc‐ β 3 hSec(PMB)‐OH for Solution and Solid‐Phase‐Peptide Synthesis and Selenoligation by Flögel, Oliver, Casi, Giulio, Hilvert, Donald, Seebach, Dieter

“…Abstract The title compounds, 4 and 7 , have been prepared from the corresponding α ‐amino acid derivative selenocystine ( 1 ) by the following sequence of…”
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Electrophilic S-Trifluoromethylation of Cysteine Side Chains in α- and β-Peptides: Isolation of Trifluoro-methylated Sandostatin® (Octreotide) Derivatives by Capone, Stefania, Kieltsch, Iris, Flögel, Oliver, Lelais, Gerald, Togni, Antonio, Seebach, Dieter

“…The new electrophilic trifluoromethylating 1‐(trifluoromethyl)‐benziodoxole reagents A and B (Scheme 1) have been used to selectively attach CF3 groups to the…”
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β-Peptidic Secondary Structures Fortified and Enforced by Zn2+ Complexation – On the Way toβ-Peptidic Zinc Fingers? by Lelais, Gérald, Seebach, Dieter, Jaun, Bernhard, Mathad, Raveendra I., Flögel, Oliver, Rossi, Francesco, Campo, Marino, Wortmann, Arno

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Preparation of β2-Amino Acid Derivatives (β2hThr, β2hTrp, β2hMet, β2hPro, β2hLys, Pyrrolidine-3-carboxylic Acid) by Using DIOZ as Chiral Auxiliary by Gessier, Francois, Schaeffer, Laurent, Kimmerlin, Thierry, Flögel, Oliver, Seebach, Dieter

“…The title compounds were prepared from valine‐derived N‐acylated oxazolidin‐2‐ones, 1–3, 7, 9, by highly diastereoselective (≥ 90%) Mannich reaction (→ 4–6;…”
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New Open-Chain and Cyclic Tetrapeptides, Consisting of α-, β2-, and β3-Amino-Acid Residues, as Somatostatin Mimics - A Survey by Seebach, Dieter, Dubost, Estelle, Mathad, Raveendra I., Jaun, Bernhard, Limbach, Michael, Löweneck, Markus, Flögel, Oliver, Gardiner, James, Capone, Stefania, Beck, Albert K., Widmer, Hans, Langenegger, Daniel, Monna, Dominique, Hoyer, Daniel

“…Cyclo‐β‐tetrapeptides are known to adopt a conformation with an intramolecular transannular hydrogen bond in solution. Analysis of this structure reveals that…”
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New Open‐Chain and Cyclic Tetrapeptides, Consisting of α ‐, β 2 ‐, and β 3 ‐Amino‐Acid Residues, as Somatostatin Mimics – A Survey by Seebach, Dieter, Dubost, Estelle, Mathad, Raveendra I., Jaun, Bernhard, Limbach, Michael, Löweneck, Markus, Flögel, Oliver, Gardiner, James, Capone, Stefania, Beck, Albert K., Widmer, Hans, Langenegger, Daniel, Monna, Dominique, Hoyer, Daniel

“…Abstract Cyclo‐ β ‐tetrapeptides are known to adopt a conformation with an intramolecular transannular hydrogen bond in solution. Analysis of this structure…”
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β-Peptidic Secondary Structures Fortified and Enforced by Zn2+ Complexation - On the Way to β-Peptidic Zinc Fingers? by Lelais, Gérald, Seebach, Dieter, Jaun, Bernhard, Mathad, Raveendra I., Flögel, Oliver, Rossi, Francesco, Campo, Marino, Wortmann, Arno

“…The correlation between β2‐, β3‐, and β2,3‐amino acid‐residue configuration and stability of helix and hairpin‐turn secondary structures of peptides consisting…”
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NMR-Solution Structures of Fluoro-Substituted β-Peptides: A 314-Helix and a Hairpin Turn. The First Case of a 90° OCCF Dihedral Angle in an α-Fluoro-Amide Group by Mathad, Raveendra I., Jaun, Bernhard, Flögel, Oliver, Gardiner, James, Löweneck, Markus, Codée, Jeroen D. C., Seeberger, Peter H., Seebach, Dieter, Edmonds, Michael K., Graichen, Florian H. M., Abell, Andrew D.

“…To further study the preference of the antiperiplanar (ap) conformation in α‐fluoro‐amide groups, two β‐peptides, 1 and 2, containing a (2‐F)‐β3hAla and a…”
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Synthese von β‐Peptiden im Mikroreaktor by Flögel, Oliver, Codée, Jeroen D. C., Seebach, Dieter, Seeberger, Peter H.

“…Die Reaktionsparameter einer β‐Peptid‐Synthese wurden in einem Mikroreaktor aus Silicium (siehe Bild) anhand minimaler Reagentienmengen optimiert. Darüber…”
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