Search Results - "Flórez Grau, Georgina"

PGE2‐EP4 signaling steers cDC2 maturation toward the induction of suppressive T‐cell responses by Cuenca‐Escalona, Jorge, Flórez‐Grau, Georgina, den Dries, Koen, Cambi, Alessandra, Vries, I. Jolanda M.

“…Dendritic cells (DCs) shape adaptive immunity in response to environmental cues such as cytokines or lipid mediators, including prostaglandin E2 (PGE2). In…”
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Tolerogenic Dendritic Cells as a Promising Antigen-Specific Therapy in the Treatment of Multiple Sclerosis and Neuromyelitis Optica From Preclinical to Clinical Trials by Flórez-Grau, Georgina, Zubizarreta, Irati, Cabezón, Raquel, Villoslada, Pablo, Benitez-Ribas, Daniel

“…The identification of activated T-lymphocytes restricted to myelin-derived immunogenic peptides in multiple sclerosis (MS) and aquaporin-4 water channel in…”
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Up‐regulation of EP2 and EP3 receptors in human tolerogenic dendritic cells boosts the immunosuppressive activity of PGE2 by Flórez‐Grau, Georgina, Cabezón, Raquel, Borgman, Kyra J. E., España, Carolina, Lozano, Juan Jose, Garcia‐Parajo, Maria F., Benítez‐Ribas, Daniel

“…PGE2 signals via EP2 and EP3 receptors to promote IL‐10 production by tol‐DCs, and potentiate their immunosuppressive properties. Dendritic cells (DCs) are…”
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Guidelines for mouse and human DC generation by Lutz, Manfred B, Ali, Shafaqat, Audiger, Cindy, Autenrieth, Stella E, Berod, Luciana, Bigley, Venetia, Cyran, Laura, Dalod, Marc, Dörrie, Jan, Dudziak, Diana, Flórez-Grau, Georgina, Giusiano, Lucila, Godoy, Gloria J, Heuer, Marion, Krug, Anne B, Lehmann, Christian H K, Mayer, Christian T, Naik, Shalin H, Scheu, Stefanie, Schreibelt, Gerty, Segura, Elodie, Seré, Kristin, Sparwasser, Tim, Tel, Jurjen, Xu, Huaming, Zenke, Martin

“…This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state-of-the-art protocols for the preparation, phenotype…”
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Three distinct tolerogenic CD14+ myeloid cell types to actively manage autoimmune disease: Opportunities and challenges by van Wigcheren, Glenn F., Roelofs, Daphne, Figdor, Carl G., Flórez-Grau, Georgina

“…Current treatment for patients with autoimmune disorders including rheumatoid arthritis, multiple sclerosis and type 1 diabetes, often consists of long-term…”
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Detection of dendritic cell subsets in the tumor microenvironment by multiplex immunohistochemistry by Hoorn, Iris A.E., Martynova, Evgenia, Subtil, Beatriz, Meek, Jelena, Verrijp, Kiek, Textor, Johannes, Flórez‐Grau, Georgina, Piet, Berber, den Heuvel, Michel M., Vries, I. Jolanda M., Gorris, Mark A. J.

“…Dendritic cells (DCs) are essential in antitumor immunity. In humans, three main DC subsets are defined: two types of conventional DCs (cDC1s and cDC2s) and…”
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Human type 1 and type 2 conventional dendritic cells express indoleamine 2,3‐dioxygenase 1 with functional effects on T cell priming by Sittig, Simone P., van Beek, Jasper J. P., Flórez‐Grau, Georgina, Weiden, Jorieke, Buschow, Sonja I., van der Net, Mirjam C., van Slooten, Rianne, Verbeek, Marcel M., Geurtz, P. Ben H., Textor, Johannes, Figdor, Carl G., de Vries, I. Jolanda M., Schreibelt, Gerty

“…Dendritic cells (DCs) are key regulators of the immune system that shape T cell responses. Regulation of T cell induction by DCs may occur via the…”
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Harnessing the cDC1-NK Cross-Talk in the Tumor Microenvironment to Battle Cancer by Bödder, Johanna, Zahan, Tasmin, van Slooten, Rianne, Schreibelt, Gerty, de Vries, I Jolanda M, Flórez-Grau, Georgina

“…Immunotherapeutic approaches have revolutionized the treatment of several diseases such as cancer. The main goal of immunotherapy for cancer is to modulate the…”
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Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination by van Beek, Jasper J.P., Flórez-Grau, Georgina, Gorris, Mark A.J., Mathan, Till S.M., Schreibelt, Gerty, Bol, Kalijn F., Textor, Johannes, de Vries, I. Jolanda M.

“…Plasmacytoid dendritic cells (pDCs) and type 2 conventional dendritic cells (cDC2s) are currently under evaluation for use in cancer vaccines. Although both DC…”
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Tailored PGE2 Immunomodulation of moDCs by Nano-Encapsulated EP2/EP4 Antagonists by Bödder, Johanna, Kok, Leanne M, Fauerbach, Jonathan A, Flórez-Grau, Georgina, de Vries, I Jolanda M

“…Prostaglandin E2 (PGE2) is an important maturation mediator for dendritic cells (DCs). However, increased PGE2 levels in the tumor exert immunosuppressive…”
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EP2 and EP4 blockade prevents tumor-induced suppressive features in human monocytic myeloid-derived suppressor cells by Cuenca-Escalona, Jorge, Subtil, Beatriz, Garcia-Perez, Alba, Cambi, Alessandra, de Vries, I Jolanda M, Flórez-Grau, Georgina

“…Tumors educate their environment to prime the occurrence of suppressive cell subsets, which enable tumor evasion and favors tumor progression. Among these,…”
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Recent Advances and Future Perspective of DC-Based Therapy in NSCLC by van der Hoorn, Iris A E, Flórez-Grau, Georgina, van den Heuvel, Michel M, de Vries, I Jolanda M, Piet, Berber

“…Current treatment for patients with non-small-cell lung cancer (NSCLC) is suboptimal since therapy is only effective in a minority of patients and does not…”
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Cisplatin inhibits frequency and suppressive activity of monocytic myeloid-derived suppressor cells in cancer patients by Van Wigcheren, Glenn F., De Haas, Nienke, Mulder, Tom A., Horrevorts, Sophie K., Bloemendal, Martine, Hins-Debree, Simone, Mao, Yumeng, Kiessling, Rolf, van Herpen, Carla M.L., Flórez-Grau, Georgina, Hato, Stanleyson V., De Vries, I. Jolanda M.

“…Cancer immunotherapies have induced long-lasting responses in cancer patients including those with melanoma and head and neck squamous cell carcinoma (HNSCC)…”
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Naturally produced type I IFNs enhance human myeloid dendritic cell maturation and IL-12p70 production and mediate elevated effector functions in innate and adaptive immune cells by Sköld, Annette E., Mathan, Till S. M., van Beek, Jasper J. P., Flórez-Grau, Georgina, van den Beukel, Michelle D., Sittig, Simone P., Wimmers, Florian, Bakdash, Ghaith, Schreibelt, Gerty, de Vries, I. Jolanda M.

“…There has recently been a paradigm shift in the field of dendritic cell (DC)-based immunotherapy, where several clinical studies have confirmed the feasibility…”
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Immune Response Generated With the Administration of Autologous Dendritic Cells Pulsed With an Allogenic Tumoral Cell-Lines Lysate in Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma by Benitez-Ribas, Daniel, Cabezón, Raquel, Flórez-Grau, Georgina, Molero, Mari Carmen, Puerta, Patricia, Guillen, Antonio, Paco, Sonia, Carcaboso, Angel M, Santa-Maria Lopez, Vicente, Cruz, Ofelia, de Torres, Carmen, Salvador, Noelia, Juan, Manel, Mora, Jaume, La Madrid, Andres Morales

“…Diffuse intrinsic pontine glioma (DIPG) is a lethal brainstem tumor in children. Dendritic cells (DCs) have T-cell stimulatory capacity and, therefore,…”
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STAT Family Protein Expression and Phosphorylation State during moDC Development Is Altered by Platinum-Based Chemotherapeutics by de Vries, I. Jolanda M., Flórez-Grau, Georgina, di Blasio, Stefania, de Koning, Coco, de Haas, Nienke, Hato, Stanleyson V.

“…The STAT signaling pathway is important in dendritic cell (DC) development and function. Tumor cells can induce STAT signaling, thereby inhibiting DC…”
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Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion by Le Gall, Camille, Cammarata, Anna, de Haas, Lukas, Ramos-Tomillero, Iván, Cuenca-Escalona, Jorge, Schouren, Kayleigh, Wijfjes, Zacharias, Becker, Anouk M D, Bödder, Johanna, Dölen, Yusuf, de Vries, I Jolanda M, Figdor, Carl G, Flórez-Grau, Georgina, Verdoes, Martijn

“…BackgroundType 1 conventional dendritic cells (cDC1s) are characterized by their ability to induce potent CD8+ T cell responses. In efforts to generate novel…”
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Human Dendritic Cell Subset Isolation by Magnetic Bead Sorting: A Protocol to Efficiently Obtain Pure Populations by Flórez-Grau, Georgina, Cuenca Escalona, Jorge, Lacasta-Mambo, Helena, Roelofs, Daphne, Bödder, Johanna, Beuk, Ruben, Schreibelt, Gerty, de Vries, I Jolanda

“…Dendritic cells have been investigated for cell-based immunotherapy for various applications. The low abundance of dendritic cells in blood hampers their…”
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Corrigendum: Immune Response Generated With the Administration of Autologous Dendritic Cells Pulsed With an Allogenic Tumoral Cell-Lines Lysate in Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma by Benitez-Ribas, Daniel, Cabezón, Raquel, Flórez-Grau, Georgina, Molero, Mari Carmen, Puerta, Patricia, Guillen, Antonio, González-Navarro, E Azucena, Paco, Sonia, Carcaboso, Angel M, Santa-Maria Lopez, Vicente, Cruz, Ofelia, de Torres, Carmen, Salvador, Noelia, Juan, Manel, Mora, Jaume, Morales La Madrid, Andres

“…[This corrects the article on p. 127 in vol. 8, PMID: 29755954.]…”
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Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial by Zubizarreta, Irati, Flórez-Grau, Georgina, Vila, Gemma, Cabezón, Raquel, España, Carolina, Andorra, Magi, Saiz, Albert, Llufriu, Sara, Sepulveda, Maria, Sola-Valls, Nuria, Martinez-Lapiscina, Elena H., Pulido-Valdeolivas, Irene, Casanova, Bonaventura, Gines, Marisa Martinez, Tellez, Nieves, Oreja-Guevara, Celia, Español, Marta, Trias, Esteve, Cid, Joan, Juan, Manel, Lozano, Miquel, Blanco, Yolanda, Steinman, Lawrence, Benitez-Ribas, Daniel, Villoslad, Pablo

“…There are adaptive T-cell and antibody autoimmune responses to myelin-derived peptides in multiple sclerosis (MS) and to aquaporin-4 (AQP4) in neuromyelitis…”
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