Search Results - "Fivush, Adam"

Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines by Collins, Jon L, Fivush, Adam M, Watson, Michael A, Galardi, Cristin M, Lewis, Michael C, Moore, Linda B, Parks, Derek J, Wilson, Joan G, Tippin, Tim K, Binz, Jane G, Plunket, Kelli D, Morgan, Daniel G, Beaudet, Elizabeth J, Whitney, Karl D, Kliewer, Steven A, Willson, Timothy M

“…A potent, selective, orally active LXR agonist was identified from focused libraries of tertiary amines. GW3965 (12) recruits the steroid receptor coactivator…”
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Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR by Maloney, Patrick R, Parks, Derek J, Haffner, Curt D, Fivush, Adam M, Chandra, Gyan, Plunket, Kelli D, Creech, Katrina L, Moore, Linda B, Wilson, Joan G, Lewis, Michael C, Jones, Stacey A, Willson, Timothy M

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Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression by Dressman, Bruce A., Tromiczak, Eric G., Chappell, Mark D., Tripp, Allie E., Quimby, Steven J., Vetman, Tatiana, Fivush, Adam M., Matt, James, Jaramillo, Carlos, Li, Renhua, Khilevich, Albert, Blanco, Maria-Jesus, Smith, Stephon C., Carpintero, Mercedes, de Diego, José Eugenio, Barberis, Mario, García-Cerrada, Susana, Soriano, José F., Schkeryantz, Jeffrey M., Witkin, Jeffrey M., Wafford, Keith A., Seidel, Wesley, Britton, Thomas, Overshiner, Carl D., Li, Xia, Wang, Xu-Shan, Heinz, Beverly A., Catlow, John T., Swanson, Steven, Bedwell, David, Ornstein, Paul L., Mitch, Charles H.

“…[Display omitted] Negative modulators of metabotropic glutamate 2 & 3 receptors demonstrate antidepressant-like activity in animal models and hold promise as…”
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Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator by Hao, Junliang, Dehlinger, Veronique, Fivush, Adam M., Rudyk, Helene C.E., Britton, Thomas C., Hollinshead, Sean P., Vokits, Benjamin P., Clark, Barry P., Henry, Steven S., Massey, Steven M., Peng, Langu, Dressman, Bruce A., Heinz, Beverly A., Roberts, Edda F., Bracey-Walker, Mallorie R., Swanson, Steven, Catlow, John T., Love, Patrick L., Tepool, Anita D., Peters, Steven C., Simmons, Rosa Maria A., Iyengar, Smriti, McKinzie, David L., Monn, James A.

“…A novel series of selective negative allosteric modulators (NAMs) for metabotropic glutamate receptor 5 (mGlu5) was discovered from an isothiazole scaffold…”
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In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat by Gilmour, Gary, Broad, Lisa M., Wafford, Keith A., Britton, Thomas, Colvin, Ellen M., Fivush, Adam, Gastambide, Francois, Getman, Brian, Heinz, Beverly A., McCarthy, Andrew P., Prieto, Lourdes, Shanks, Elaine, Smith, Janice W., Taboada, Lorena, Edgar, Dale M., Tricklebank, Mark D.

“…The demonstrated functional interaction of metabotropic glutamate 5 (mGlu5) receptors with N-methyl-d-aspartate (NMDA) receptors has prompted speculation that…”
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Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity by Sznaidman, Marcos L., Haffner, Curt D., Maloney, Patrick R., Fivush, Adam, Chao, Esther, Goreham, Donna, Sierra, Michael L., LeGrumelec, Christelle, Xu, H.Eric, Montana, Valerie G., Lambert, Millard H., Willson, Timothy M., Oliver, William R., Sternbach, Daniel D.

“…We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ)…”
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AMEBA: An acid sensitive aldehyde resin for solid phase synthesis by Fivush, Adam M., Willson, Timothy M.

“…Oxidation of 4-(3-methoxy-4-hydroxymethylphenoxy)methyl polystyrene resin produced AMEBA resin 1, a novel acid sensitive aldehyde resin. Reductive amination of…”
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Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library by Brown, Peter J., Smith-Oliver, Tracey A., Charifson, Paul S., Tomkinson, Nicholas C.O., Fivush, Adam M., Sternbach, Daniel D., Wade, Laura E., Orband-Miller, Lisa, Parks, Derek J., Blanchard, Steven G., Kliewer, Steven A., Lehmann, Jürgen M., Willson, Timothy M.

“…Background: The peroxisome proliferator-activated receptors (PPARs) were cloned as orphan members of the nuclear receptor superfamily of transcription factors…”
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